Tohgo Akira | Researcher Information

cyclic ADP-ribose結合蛋白質の構造解析
ヒトFK506結合蛋白質の構造決定と転写調節の解明
Characterization of the gene encoding cyclic ADP-ribose binding protein
Structure and promoteranalysis of FK506 Binding protein 12.6

F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, Kato, I, S Kobayashi, T Akiyama, S Takasawa, T Toyota, et al. Autoantibodies against CD38 (ADP ribosyl cyclase cyclic ADP ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients. JOURNAL OF CLINICAL INVESTIGATION. 1998. 102. 2. 395-401
F Ikehata, J Satoh, K Nata, A Tohgo, T Nakazawa, Kato, I, S Kobayashi, T Akiyama, S Takasawa, T Toyota, et al. Autoantibodies against CD38 (ADP ribosyl cyclase cyclic ADP ribose hydrolase) that impair glucose-induced insulin secretion in noninsulin-dependent diabetes patients. JOURNAL OF CLINICAL INVESTIGATION. 1998. 102. 2. 395-401
K. Yagui, F. Shimada, M. Mimura, N. Hashimoto, Y. Suzuki, Y. Tokuyama, K. Nata, A. Tohgo, F. Ikehata, S. Takasawa, et al. A missense mutation in the CD38 gene, a novel factor for insulin secretion: Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. Diabetologia. 1998. 41. 9. 1024-1028
S Takasawa, T Akiyama, K Nata, M Kuroki, A Tohgo, N Noguchi, S Kobayashi, Kato, I, T Katada, H Okamoto. Cyclic ADP-ribose and inositol 1,4,5-trisphosphate as alternate second messengers for intracellular Ca2+ mobilization in normal and diabetic beta-cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 1998. 273. 5. 2497-2500
K. Yagui, F. Shimada, M. Mimura, N. Hashimoto, Y. Suzuki, Y. Tokuyama, K. Nata, A. Tohgo, F. Ikehata, S. Takasawa, et al. A missense mutation in the CD38 gene, a novel factor for insulin secretion: Association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro. Diabetologia. 1998. 41. 9. 1024-1028

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A role of cyclic ADP-ribose, a NAD<SUP>+</SUP> metabolite, in stimulus-secretion coupling in pancreatic B-cell.
Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon 1995
A role of cyclic ADP-ribose, a NAD<SUP>+</SUP> metabolite, in stimulus-secretion coupling in pancreatic B-cell.
Frontiers of Insulin Secretion and Pancreatic B-Cell Research (Fratt, P. and Lenzen, S., eds.), Smith-Gordon 1995

医学博士

1998 - 東北大学医学部奨励賞銀賞
1996 - 第33回ベルツ賞

日本糖尿病学会 , 日本生化学会