Rchr
J-GLOBAL ID：200901007993219692
Update date: Jul. 25, 2024
Oishi Tohru
オオイシ トオル | Oishi Tohru
Affiliation and department：
Job title：
Associate Professor
Homepage URL (1)：
http://www.scc.kyushu-u.ac.jp/Seibutsuyuki/index.htm
Research field (2)：
Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (5)：
有機合成化学
, 天然物化学
, Bioorganic Chemistry
, Synthetic Organic Chemistry
, Natural Products Chemistry
Research theme for competitive and other funds (33)：
- 2023 - 2026 Structure-Activity Relationship Study of Maitotoxin Based on Chemical Synthesis
- 2021 - 2024 Development of a novel antifungal agent based on the membrane acting molecule which discriminate human and fungal membrane
- 2019 - 2022 Design and synthesis of calcium ion regulatory molecules based on maitotoxin
- 2018 - 2020 Elucidation of stereochemistry and biological function by total synthesis of super-carbon-chain natural products
- 2016 - 2019 Elucidation of mode-of-action of maitotoxin based on chemical synthesis
- 2016 - 2018 Development of efficient synthetic method of super-carbon-chain compounds by reaction integration and analysis of biological function
- 2015 - 2017 Development of novel antifungal based on chemical synthesis
- 2012 - 2016 Synthetic Studies of Maitotoxin to Elucidate Mode-of-Action
- 2012 - 2015 Synthetic approaches for the elucidation of structure, conformation and functions of an antifungal natural product amphidinol 3
- 2012 - 2014 空間的反応集積化と多重反応を用いた超効率的天然物合成法の開発
- 2010 - 2011 梯子状ポリエーテル天然物のマイクロフロー合成
- 2009 - 2011 Synthetic studies of the hydrophobic part of maitotoxin for elucidating its target proteins
- 2006 - 2010 Structures and Functions of Membrane-Bound Biomolecules
- 2006 - 2008 Total Synthesis of Antitumor Marine Polyethers for Exploring Mode of Action
- 2004 - 2007 膜蛋白質と相互作用する生体機能分子の合成と機能解析
- 2005 - 2006 自己組識化して活性を発現する天然物アンフィジノールの全合成と分子複合体の構造解析
- 2003 - 2005 Structure of Molecular Assembles of Bioactive Natural Products Formed in Biomembranes
- 2003 - 2005 Synthetic studies of yessotoxin aiming at biological functions
- 2003 - 2004 膜タンパク質機能制御を目指した梯子状ポリエーテルライブラリーの合成
- 2002 - 2003 下痢性貝毒イェッソトキシンおよびアドリアトキシンの不斉全合成研究
- 2000 - 2002 Synthetic study directed towards marine neurotoxin ciguatoxin and elucidation of its mode of action
- 2001 - 2001 効率的環状ポリエーテル合成法を利用した神経毒イェッソトキシンの全合成研究
- 2000 - 人工梯子状ポリエーテル分子の合成と膜蛋白質との相互作用解析
- 1997 - 1999 Preparation of Anti-Ciguatoxin Antibody and Synthetic Study of Ciguatoxin Science
- 1996 - 1996 ブレベトキシンAの合成研究
- 1995 - 1995 シガトキシンの全合成研究
- 1993 - 1993 オレフィン類の高選択的不斉酸化触媒の開発
- ユウレイボヤ精子活性化誘引物質の化学合成
- チャネル複合体の構造解明を目指した標識化アンフォテリシンBの合成研究
- イエツソトキシンの全合成研究
- Synthetic Study of Yessotoxin
- Synthetic Study of Korormicin
- Synthetic Study of Ciguatoxin
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Papers (124)：
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Masahiro Kaneko, Atsuhiro Yamashita, Yoko Yasuno, Kosei Yamauchi, Ken Sakai, Tohru Oishi. Synthesis of the MN Ring of Caribbean Ciguatoxin C-CTX-1 via Desymmetrization by Acetal Formation. Organic Letters. 2024. 26. 4. 855-859
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Nobuaki Matsumori, Manami Hieda, Masayuki Morito, Yuma Wakamiya, Tohru Oishi. Truncated derivatives of amphidinol 3 reveal the functional role of polyol chain in sterol-recognition and pore formation. Bioorganic & Medicinal Chemistry Letters. 2024
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Tohru Oishi, Keitaro Umeno, Hiroshi Yamaguchi, Tatsuya Teshigawara, Yoko Yasuno. Large-Scale Synthesis of the Key Intermediates of Tetrahydropyran Derivatives under Flow Conditions. HETEROCYCLES. 2023. 106. 10. 1741-1741
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Yuichi Umegawa, Tomoya Yamamoto, Mayank Dixit, Kosuke Funahashi, Sangjae Seo, Yasuo Nakagawa, Taiga Suzuki, Shigeru Matsuoka, Hiroshi Tsuchikawa, Shinya Hanashima, et al. Amphotericin B assembles into seven-molecule ion channels: An NMR and molecular dynamics study. Science advances. 2022. 8. 24. eabo2658
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Keitaro Umeno, Hisaaki Onoue, Keiichi Konoki, Kohei Torikai, Yoko Yasuno, Masayuki Satake, Tohru Oishi. Convergent Synthesis of the WXYZA′B′C′D′E′F′ Ring Segment of Maitotoxin. Bulletin of the Chemical Society of Japan. 2022. 95. 2. 325-330
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MISC (106)：
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鳥山加奈子, 保野陽子, 鳥飼浩平, 佐竹真幸, 大石徹. Synthetic Study of the NOPQ Ring and STUV Ring of Brevisulcenal-F. 日本化学会春季年会講演予稿集(Web). 2021. 101st
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三苫研人, 田中達也, 保野陽子, 鳥飼浩平, 佐竹真幸, 大石徹. Synthetic Study of the VWX Ring of Brevisulcenal-F for Elucidating Relative Configuration. 日本化学会春季年会講演予稿集(Web). 2021. 101st
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梅野圭太郎, 尾上久晃, 此木敬一, 鳥飼浩平, 保野陽子, 大石徹. Synthetic Study of the W-F’ Ring Segment of Maitotoxin. 日本化学会春季年会講演予稿集(Web). 2021. 101st
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Hiroshi Tsuchikawa, Yuichi Umegawa, Michio Murata, Tohru Oishi. A synthetic approach to the channel complex structure of antibiotic in a membrane: Backbone 19F-labeled amphotericin B for solidstate NMR analysis. Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 2018. 76. 11. 1197-1205
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YAMAMOTO TAKUYA, KOSAKA KOJI, TORIKAI KOHEI, YOSHIDA KAORU, OISHI TOORU, YOSHIDA MANABU. SAAF誘導体の活性比較によるSAAFの作用メカニズムの考察. 日本動物学会大会予稿集. 2014. 85th. 136
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Lectures and oral presentations (1)：
-
Total Synthesis of Amphidinol 3
(Pacifichem 2021 2021)
Works (4)：
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Synthesis of Diacylglycerols
1995 - 2000
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Z-Selective Horner-Wadsworth-Emmons Reaction
1999 -
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The absolute configuration and total synthesis of korormicin
1997 -
-
ユウレイボヤ精子活性化物質の作用機構解明
Education (4)：
- - 1992 Tohoku University
- - 1992 Tohoku University Graduate School, Division of Natural Science
- - 1987 Tohoku University Faculty of Science
- - 1987 Tohoku University Faculty of Science
Professional career (1)：
- Doctor of Science (Tohoku University)
Work history (11)：
- 2010 - 現在 Kyushu University Graduate School of Science Professor
- 2002 - 2010 Osaka University Graduate School of Science
- 2000 - 2002 Osaka University Graduate School of Science
- 2000 - 2002 Graduate School of Science, Osaka University, Lecturer
- 2002 - - Graduate School of Science, Osaka University, Associate Professor
- 1998 - 2000 Tohoku University Graduate School of Science
- 1998 - 2000 Graduate School of Science, Tohoku University, Lecturer
- 1995 - 1998 Tohoku University Graduate School of Science
- 1995 - 1998 Graduate School of Science, Tohoku University, Research Assistant
- 1992 - 1995 Tohoku University Faculty of Science
- 1992 - 1995 Faculty of Science, Tohoku University, Research Assistant
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Committee career (1)：
Awards (6)：
- 2023/04 - Nagase Science and Technology Foundation Nagase Foundation Award 2023 Design and synthesis of molecules that control Ca2+ influx based on marine natural toxin maitotoxin
- 2022/02 - Chemical Society of Japan BCSJ Award Convergent Synthesis of the WXYZA’B’C’D’E’F’ Ring Segment of Maitotoxin.
- 2019/03 - The Chemical Society of Japan The Chemical Society of Japan Award for Creative Work for 2018 Structure Determination, Chemical Synthesis, and Evaluation of Biological Activity of Super Carbon Chain Natural Products
- 2016 - Asian Core Program (ACP) Advanced Research Network Lectureship Award (2016)
- 2001 - BCSJ賞
- 2001 - Incentive Award in Synthetic Organic Chemistry, Japan
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Association Membership(s) (3)：
有機合成化学協会
, アメリカ化学会
, 日本化学会
