Motoyama Jun

モトヤマジユン | Motoyama Jun

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Research field (2)： Neuroscience - general , Developmental biology

Research keywords (5)： Neonatal development , Neural development , developmental biology , embryo , neural stem cell

Research theme for competitive and other funds (7)：

2020 - 2023 マウス大脳皮質発生過程でのCa2+依存的低濃度Shhシグナル伝達経路の解明
2016 - 2018 Molecular mechanisms of the action of maternal diabetes on the midline determination during mouse brain development
2010 - 2012 Analyses of the role of Shh-expressing cells during mammalian cortical development
2004 - 2005 マウス神経幹細胞の細胞分化・分裂過程における癌抑制遺伝子PTC1の機能の解明
2002 - 2003 多様化したソニックヘッジホッグカスケードによる神経管の発生制御(2)

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Papers (40)：

Watanabe-Takahashi M, Kumoi K, Yamamoto H, Shimizu E, Motoyama J, Hamabata T, Nishikawa K. Tailored multivalent peptide targeting the B-subunit pentamer of Cholera toxin inhibits its intestinal toxicity by inducing aberrant transport of the toxin in cells. Biochem. Biophys. Res. Commun. 2024. 716. 149991
Koji Oishi, Kazunori Nakajima, Jun Motoyama. Activation of Sonic Hedgehog Signaling Promotes Differentiation of Cortical Layer 4 Neurons via Regulation of Their Cell Positioning. Journal of Developmental Biology. 2022. 10. 4. 50-50
Putu Adi Andhika Rhaditya, Koji Oishi, Yoshiaki V. Nishimura, Jun Motoyama. [Ca2+] fluctuation mediated by T-type Ca2+ channel is required for the differentiation of cortical neural progenitor cells. Developmental Biology. 2022. 489. 84-97
Yuki Murakami, Yukio Imamura, Kuniaki Saito, Daisuke Sakai, Jun Motoyama. Author Correction: Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker (Scientific Reports, (2019), 9, 1, (13182), 10.1038/s41598-019-49781-y). Scientific Reports. 2020. 10. 1
Yuki Murakami, Yukio Imamura, Kuniaki Saito, Daisuke Sakai, Jun Motoyama. Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker. Scientific reports. 2019. 9. 1. 13182

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MISC (13)：

Toshiaki Okada, Yuki Okumura, Jun Motoyama, Masaharu Ogawa. FGF8 signaling patterns telencephalic midline by regulating putative key factors of midline development. NEUROSCIENCE RESEARCH. 2008. 61. S155-S155
Jun Motoyama, Yayoi Shikata, Mitsuhiro Hashimoto, Toshiaki Okada, Masaharu Ogawa. Role of Ptch1 in neural stem cell maintenance during mouse brain development. NEUROSCIENCE RESEARCH. 2008. 61. S156-S156
M Ishibashi, H Saitsu, M Komada, M Suzuki, R Nakayama, J Motoyama, K Shiota. Expression of the mouse Fgf15 gene is directly initiated by sonic hedgehog signaling in the diencephalon and midbrain. FASEB JOURNAL. 2006. 20. 5. A878-A878
T. Ellis, M. Bourboulas, J. Robson, C. Adolphe, N. Bull, J. Motoyama, P. Bartlett, B. Reynolds, B. Wainwright. Hedgehog Signalling Regulates Both Neurogenesis and Lamination in the Dorsal Forebrain and Midbrain. MOLECULAR BIOLOGY OF THE CELL. 2006. 17
E Nieuwenhuis, J Motoyama, Y Yoshikawa, XY Zhang, R Mo, MA Crackower, CC Hui. Alopecia and epidermal hyperplasia in adult male mice lacking normal Patched2 function. DEVELOPMENTAL BIOLOGY. 2004. 271. 2. 625-625

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Professional career (1)：

Work history (7)：

2024/04 - 現在 Doshisha University Center for Baby Science Director
2012/04 - 現在 Doshisha university Graduate school of brain science Professor
2009/04 - 2012/03 Doshisha university Department of Medical Life Systems, Faculty of Life and Medical Science Professor
2004/04 - 2009/03 RIKEN Brain Science Institute Unit Leader
1999 - 2004 RIKEN Brain Science Institute Senior Scientist

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