Affiliation and department：
Homepage URL (2)：
Update date: Jun. 03, 2020
シンドウ タカユキ | SHINDO TAKAYUKI
Research field (2)：
Research theme for competitive and other funds (5)：
Metabolism and endocrinology
- Development of novel technique for genome editing
- Generation of novel genetically engineerd mice.
- Regenerative medicine of blood vessel.
- Pathophysiological roles of vasoactive peptides and their receptor system.
- Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.
Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T, Development of, a, mouse iron overload-induced liver injury model, evaluation of, the, beneficial effects of, placenta extract on iron, m. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism. Heliyon. 2019. 10;5(5):e01637
Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T. Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system. Peptides. 2019. 111. 55-61
Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T. Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-RAMP2 system. Am J Pathol. 2019. 189. 2. 449-466
Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T. Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase. Sci Rep. 2019. 9:9923
Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T. Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline. J Hypertens. 2018. 36. 4. 876-891
Lectures and oral presentations (9)：
Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line.
Noninheritable maternal factors useful for genetic manipulation in mammals.
Oocytes Maternal information and functions
Knockout mice and transgenic mice. Nishikimi T eds: Adrenomedullin in Cardiovascular Disease
Springer, New Jersey 2005
Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration
(Association for research in Vision and Ophthalmology 2019)
Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin
(Congress of Asia-Pacific Academy of Ophthalmology 2019)
Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion
(The Association for Research in Vision and Ophthalmology 2018)
Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
(The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium 2014)
Pathophysiological roles and potential applications of vasoactive peptides and their receptor regulation system.
Professional career (1)：
- - 1998 University of Tokyo
- - 1991 University of Tokyo
Work history (2)：
- Ph.D. in Cardiovascular Science (University of Tokyo)
Return to Previous Page
- 2004/08/15 - Professor, Department of Cardiovascular Research, Shinshu University, School of Medicine
- 2002/07/01 - Assistant Professor, Department of Cardiovascular Medicine, University of Tokyo