J-GLOBAL ID:200901008308102423   Update date: Jun. 03, 2020


Affiliation and department:
Homepage URL  (2): http://www7a.biglobe.ne.jp/~shindo/http://www7a.biglobe.ne.jp/~shindo/
Research field  (2): Metabolism and endocrinology ,  Cardiology
Research theme for competitive and other funds  (5):
  • Development of novel technique for genome editing
  • Generation of novel genetically engineerd mice.
  • Regenerative medicine of blood vessel.
  • Pathophysiological roles of vasoactive peptides and their receptor system.
  • Development of new therapy using animal models of atherosclerosis, hypertension, heart failure, renal failure and liver failure.
Papers (82):
  • Yamauchi A, Kamiyoshi A, Sakurai T, Miyazaki H, Hirano E, Lim HS, Kaku T, Shindo T, Development of, a, mouse iron overload-induced liver injury model, evaluation of, the, beneficial effects of, placenta extract on iron, m. Development of a mouse iron overload-induced liver injury model and evaluation of the beneficial effects of placenta extract on iron metabolism. Heliyon. 2019. 10;5(5):e01637
  • Shindo T, Tanaka M, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yamauchi A, Sakurai T. Regulation of cardiovascular development and homeostasis by the adrenomedullin-RAMP system. Peptides. 2019. 111. 55-61
  • Hirabayashi K, Tanaka M, Imai A, Toriyama Y, Iesato Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Dai K, Cui N, Wei Y, Nakamura K, Iida S, Matsui S, Yamauchi A, Murata T, Shindo T. Development of a novel model of central retinal vascular occlusion and therapeutic potential of adrenomedullin-RAMP2 system. Am J Pathol. 2019. 189. 2. 449-466
  • Sakurai T, Kamiyoshi A, Takei N, Watanabe S, Sato M, Shindo T. Bindel-PCR: a novel and convenient method for identifying CRISPR/Cas9-induced biallelic mutants through modified PCR using Thermus aquaticus DNA polymerase. Sci Rep. 2019. 9:9923
  • Zhai L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Tanaka M, Xian X, Hirabayashi K, Dai K, Cui N, Tanimura K, Liu T, Wei Y, Tanaka M, Tomiyama H, Yamauchi A, Igarashi K, Shindo T. Endogenous calcitonin gene-related peptide suppresses ischemic brain injuries and progression of cognitive decline. J Hypertens. 2018. 36. 4. 876-891
Books (4):
  • Isolation and analysis of a genome-edited single-hepatocyte from a Cas9 transgenic mouse line.
  • Noninheritable maternal factors useful for genetic manipulation in mammals.
  • Oocytes Maternal information and functions
  • Knockout mice and transgenic mice. Nishikimi T eds: Adrenomedullin in Cardiovascular Disease
    Springer, New Jersey 2005
Lectures and oral presentations  (9):
  • Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration
    (Association for research in Vision and Ophthalmology 2019)
  • Development of a retinal vascular occlusion model in mice and analysis of the pathophysiological roles of adrenomedullin
    (Congress of Asia-Pacific Academy of Ophthalmology 2019)
  • Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion
    (The Association for Research in Vision and Ophthalmology 2018)
  • Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis
    (The Conference on Bioactive Peptides for Cell-Cell Communication 2014 Symposium 2014)
  • Pathophysiological roles and potential applications of vasoactive peptides and their receptor regulation system.
Education (2):
  • - 1998 University of Tokyo
  • - 1991 University of Tokyo
Professional career (1):
  • Ph.D. in Cardiovascular Science (University of Tokyo)
Work history (2):
  • 2004/08/15 - Professor, Department of Cardiovascular Research, Shinshu University, School of Medicine
  • 2002/07/01 - Assistant Professor, Department of Cardiovascular Medicine, University of Tokyo
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