Koji Hase

ハセコウジ | Koji Hase

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://square.umin.ac.jp/keio-dbc/ , http://square.umin.ac.jp/keio-dbc/

Research field (2)： Gastroenterology , Immunology

Research keywords (4)： Inflammatory bowel disease , Microfold cells , Intestinal Micorobiology , Mucosal Immunology

Research theme for competitive and other funds (5)：

2020 - 2023 Starvation response of the immune system along the gut-bone marrow axis
2017 - 2020 多変量解析による慢性炎症スパイラル形成機構の解明
2017 - 2020 Elucidation of T-independent IgA class switch machinery
2016 - 2018 Single cell analysis of T lymphocytes in the intestinal immune system
2016 - 2018 生物間代謝経路によって制御される脂質クオリティの解析

Papers (112)：

Yutaka Nakamura, Hitomi Mimuro, Jun Kunisawa, Yukihiro Furusawa, Daisuke Takahashi, Yumiko Fujimura, Tsuneyasu Kaisho, Hiroshi Kiyono, Koji Hase. Microfold cell-dependent antigen transport alleviates infectious colitis by inducing antigen-specific cellular immunity. Mucosal Immunology. 2020. 13. 4. 679-690
Ikuo Kimura, Junki Miyamoto, Ryuji Ohue-Kitano, Keita Watanabe, Takahiro Yamada, Masayoshi Onuki, Ryo Aoki, Yosuke Isobe, Daiji Kashihara, Daisuke Inoue, et al. Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice. Science (New York, N.Y.). 2020. 367. 6481. eaaw8429
Shunsuke Kimura, Yutaka Nakamura, Nobuhide Kobayashi, Katsuyuki Shiroguchi, Eiryo Kawakami, Mami Mutoh, Hiromi Takahashi-Iwanaga, Takahiro Yamada, Meri Hisamoto, Midori Nakamura, et al. Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity. Nature communications. 2020. 11. 1. 234-234
Takahashi D, Hoshina N, Kabumoto Y, Maeda Y, Suzuki A, Tanabe H, Isobe J, Yamada T, Muroi K, Yanagisawa Y, et al. Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells. EBioMedicine. 2020. in press
Junya Isobe, Shintarou Maeda, Yuuki Obata, Keito Iizuka, Yutaka Nakamura, Yumiko Fujimura, Tatsuki Kimizuka, Kouya Hattori, Yun-Gi Kim, Tatsuya Morita, et al. Commensal-bacteria-derived butyrate promotes the T cell-independent IgA response in the colon. International immunology. 2019

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MISC (67)：

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Books (6)：

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Lectures and oral presentations (61)：

飢餓ストレスによるリンパ球の動態制御
(2017年度生命科学系学会合同年次大会 (ConBio2017) 2017)
腸内細菌由来の酪酸による全身性自己免応答の制御
(第22回日本食物繊維学会 2017)
マイクロバイオータとアレルギー
(第54回小児アレルギー学会 2017)
Intestinal microbiota-derived metabolites regulate autoimmunity through epigenetic modifications
(Fujihara Seminar 2017)
Microbiota-derived metabolites shape host immunity
(第59回歯科基礎医学会学術大会 2017)

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Work history (6)：

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Awards (6)：

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