Rchr
J-GLOBAL ID：200901008477349535
Update date: Apr. 10, 2024
Goi Kumiko
Goi Kumiko
Research field (1)：
Fetal medicine/Pediatrics
Research keywords (6)：
Pediatric hematorogy/oncorogy
, 小児腫瘍学
, 小児血液学
, 小児科学
, Pediatric oncology
, Pediatric hematology
Research theme for competitive and other funds (24)：
- 2022 - 2025 小児難治性腫瘍におけるmitotic slippageの克服
- 2022 - 2025 難治性急性リンパ性白血病に対するプレシジョン・メディシンを目指した多分野融合研究
- 2019 - 2022 Integrated study aiming at development of precision medicine for poor prognostic acute lymphoblastic leukemia
- 2018 - 2021 Enhancement of the antitumor effect of allogeneic NK cells by inhibition of TGF-beta pathway
- 2015 - 2018 Establishment of a new disease model by congenital p53 hyperactive mutation
- 2013 - 2016 CD44-targetted therapy for CD44-high expressing tumors by ultra-low-molecular-weight hyaluronan
- 2011 - 2013 The cytotoxic effect by natural killer cells against pediatric malignant solid tumors
- 2008 - 2010 The cytotoxic effect by natural killer cells against pediatric malignant tumors.
- 2007 - 2008 Involvement of Slug transcription factor, a human homolog of ces-1 of C. elegans, in the regulation of apoptotic cell death of leukemia cells
- 2006 - 2007 Analysis of the FLT3/FLT3 ligand system in ALL with 11q23 translocations
- 2004 - 2006 Establishment of new-therapy and analysis of mechanisms for resistance to apoptosis in poor-prognostic childhood leukemia
- 2004 - 2005 Anti-leukemic activity of cytotoxic ligands against poor-prognostic childhood leukemia
- 2004 - 2005 anti-leukemic activity of FLT3 inhibitor on childhood acute lymphoblastic leukemia with 11q23 translocation
- 2003 - 2004 Histone acetylation in childhood high-risk acute leukemia
- 2002 - 2003 Anti-leukemic activities of TNF-family ligands in childhood poor-prognostic leukemia
- 2002 - 2003 Analysis of tumor supressor genes p16 and Rb in childhood acute lymphoblastic leukemia
- 2001 - 2003 Resistance to apoptosis in childhood poor-prognostic leukemia
- 2001 - 2002 小児急性白血病におけるBH3 onlyの解析とその臨床的意義
- 1998 - 2000 The pivotal role of apoptosis in leukemogenesis and chemo-sensitivity in childhood leukemias.
- 1994 - 1996 Analysis of immunological reconstitution after allogeneic bone marrow transplantation
- 1994 - 1994 反応性組織球増多症におけるEB感染の病態に関する研究
- Analysis of mechanism of cell cycle contiol in leukemic cells
- 白血病細胞における細胞周期制御機構の解析
- mechanism of leukemogenesis in childhood leukemia
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Papers (117)：
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Kazuya Takahashi, Thao Thu Thi Nguyen, Atsushi Watanabe, Hiroki Sato, Kinuko Saito, Minori Tamai, Daisuke Harama, Shin Kasai, Koshi Akahane, Kumiko Goi, et al. Involvement of BCR::ABL1 in laminin adhesion of Philadelphia chromosome-positive acute lymphoblastic leukemia through upregulation of integrin α6. Cancer reports (Hoboken, N.J.). 2024. 7. 4. e2034
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Thao Nguyen, Tomomi Aida, Yuka Iijima-Yamashita, Minori Tamai, Akiko Nagamachi, Keiko Kagami, Chiaki Komatsu, Shin Kasai, Koshi Akahane, Kumiko Goi, et al. Application of prime editing system to introduce TP53 R248Q hotspot mutation in acute lymphoblastic leukemia cell line. Cancer science. 2024
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Shin Kasai, Minori Tamai, Eiji Sugihara, Naoki Oishi, Kyoko Hinata, Koshi Akahane, Kumiko Goi, Yuko Hata, Tetsuo Kondo, Takahiko Mitsui, et al. In utero tumor development and identification of CTNNB1 mutation in a newborn case of ossifying renal tumor of infancy. Pediatric blood & cancer. 2024. e30868
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Atsushi Watanabe, Kunio Miyake, Yuriko Yamada, Ei-Ichiro Sunamura, Takuya Yotani, Keiko Kagami, Shin Kasai, Minori Tamai, Daisuke Harama, Koshi Akahane, et al. Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL. Epigenetics. 2023. 18. 1. 2268814-2268814
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Koshi Akahane, Shin Kasai, Atsushi Watanabe, Keiko Kagami, Chiaki Komatsu, Minori Tamai, Kumiko Goi, Naoki Oishi, Akihiko Yoshida, Chitose Ogawa, et al. FGFR1 tyrosine kinase domain duplication in infantile soft tissue spindle cell tumor. Pediatric blood & cancer. 2023. e30354
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MISC (205)：
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Minori Tamai, Thao Nguyen, Chiaki Komatsu, Keiko Kagami, Shin Kasai, Daisuke Harama, Koshi Akahane, Kumiko Goi, Takeshi Inukai. p210 and p190 BCR::ABL1 INDUCE DIFFERENT GENE EXPRESSION PROFILES IN THE ARTIFICIAL PHILADELPHIA CHROMOSOME-POSITIVE LEUKEMIAS CREATED BY CRISPR/Cas9 SYSTEM. PEDIATRIC BLOOD & CANCER. 2022. 69
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合井久美子, 渡邊敦, 佐野友昭, 古市嘉行, 太田正法, 高橋和也, 原間大輔, 小林浩司, 中村誠, 溝呂木園子, et al. COVID-19対策としてリモート形式で開催した3回の山梨小児医療セミナーのアンケート結果について. 日本小児科学会雑誌. 2022. 126. 4
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原間大輔, 合井久美子, 齋藤衣子, 佐藤広樹, 杣津晋平, 古市嘉行, 高橋和也, 大城浩子, 中村誠, 犬飼岳史. Changes in prevalence of immune thrombocytopenia during COVID-19 pandemic. 日本小児血液・がん学会雑誌(Web). 2022. 59. 4
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原間大輔, 赤羽弘資, 渡邊敦, 篠原珠緒, 大城浩子, 合井久美子, 沼野史典, 蓮田憲夫, 犬飼岳史. Progressive dyspnea due to airway constriction by primary tumor in an infant with posterior mediastinum neuroblastoma. 日本小児血液・がん学会雑誌(Web). 2021. 58. 4
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渡邊敦, 原間大輔, 笠井慎, 赤羽弘資, 合井久美子, 犬飼岳史. Development of kidney stones during induction therapy in a girl with T-cell acute lymphoblastic leukemia. 日本小児血液・がん学会雑誌(Web). 2021. 58. 4
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Lectures and oral presentations (133)：
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T細胞型急性リンパ性白血病におけるTRAIL受容体DR4/DR5の低発現と遺伝子メチル化との関連性
(日本血液学会 2008)
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17;19転座型急性リンパ性白血病の臨床像
(第49回日本小児血液学会、第23回日本小児がん学会 2007)
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FLT3-ligand刺激はMLL再構成陽性ALL細胞に抗癌剤抵抗性を誘導する 新鮮ALL細胞を用いた検討
(第49回日本小児血液学会、第23回日本小児がん学会 2007)
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発症時に肺炎球菌敗血症を合併した急性リンパ性白血病(ALL)の2例
(第49回日本小児血液学会、第23回日本小児がん学会 2007)
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Imatinibで細胞遺伝学的寛解へ導入後にRISTを行なったCMLの女児例
(第49回日本小児血液学会、第23回日本小児がん学会 2007)
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Education (1)：
- - 1988 Yamanashi Medical University Faculty of Medicine
Professional career (1)：
Work history (3)：
- 2007/04 - University of Yamanashi Human Science (Science education), Graduate Faculty of Interdisciplinary Research Faculty of Education
- 2002/10 - University of Yamanashi Human Science (Science education), Graduate Faculty of Interdisciplinary Research Faculty of Education
- 2000/03 - 山梨医科大学助手(小児科学)
Awards (2)：
- 2017/03 - 山梨県医師会 山梨県医師会学術奨励賞 進行性神経芽腫に対する同種移植療法
- 2002 - 日本小児血液学会 大谷賞
Association Membership(s) (7)：
日本造血細胞移植学会
, 日本がん学会
, 日本小児血液・がん学会
, 日本臨床血液学会
, 日本血液学会
, 日本小児科学会
, 山梨血液研究会
