J-GLOBAL ID:200901008511543320   Update date: Jan. 11, 2020


スギヤマ アツシ | SUGIYAMA Atsushi
Affiliation and department:
Research field  (1): General pharmacology
Research keywords  (1): Candiovascular Pharmacology
Research theme for competitive and other funds  (3):
  • Biochemistry in atrio-ventricular conduction
  • Research of drug induced long QT syndrome
  • Development of cardiopulmonary drugs for resuscitation
Papers (93):
  • Kambayashi R, Hagiwara-Nagasawa M, Kondo Y, Yeo ZJ, Goto A, Chiba K, Nunoi Y, Izumi-Nakaseko H, Leow JWH, Venkatesan G, Matsumoto A, Chan ECY, Sugiyama A. How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone. Cardiovascular toxicology. 2020
  • Kambayashi R, Hagiwara-Nagasawa M, Goto A, Chiba K, Izumi-Nakaseko H, Naito AT, Matsumoto A, Sugiyama A. In vivo characterization of rate-dependent impact on the QT interval of microminipig assessed by atrial electrical pacing: Development of correction formulae of QT interval. The Journal of veterinary medical science. 2019. 81. 12. 1735-1739
  • Tanikawa Y, Hagiwara-Nagasawa M, Kambayashi R, Goto A, Chiba K, Kitta K, Hoshiai K, Izumi-Nakaseko H, Naito AT, Sugiyama A. Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions. Cardiovascular toxicology. 2019. 19. 5. 412-421
  • Kambayashi R, Hagiwara-Nagasawa M, Goto A, Chiba K, Izumi-Nakaseko H, Naito AT, Matsumoto A, Sugiyama A. Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin-dopamine antagonists against insomnia and nocturnal delirium. Heart and vessels. 2019
  • Täubel J, Prasad K, Rosano G, Ferber G, Wibberley H, Cole ST, Van Langenhoven L, Fernandes S, Djumanov D, Sugiyama A. Effects of the Fluoroquinolones Moxifloxacin and Levofloxacin on the QT Subintervals: Sex Differences in Ventricular Repolarization. Journal of clinical pharmacology. 2019
MISC (123):
Patents (1):
  • Enzymatic fluorometric assay for adenylate cyclase. United States Patent Number 5,618,665
Lectures and oral presentations  (215):
  • Inhibition of Na+/H+ exchange suppresses both overshoot phenomenon of myocardial creatine phoshate and lethal arrhythmias during coronary reperfusion
    (70 th Scientific Sessions of American heart association 1997)
  • 抗不整脈薬以外の薬物の催不整脈作用-慢性徐脈犬での検討-
    (第7回循環薬理研究会 1997)
  • Inhibition of Na+/H+ exchange suppersses boh rebound recovery of myocardial creatine phosphate(Cr-P) and lethal arrhythmias during reperfution after a brief ischemia
    (The 61 th Annual Scientific meeting of Japaneses Circulation Society 1997)
  • 消化管運動改善薬TKS159およびcisaprideの心血管系におよぼす作用:再分極過程延長様式における差異
    (第14回日本心電学会学術集会 1997)
  • Cardiovascular and respiratory safety pharmacology.
    (第27回トキシコロジー学会学術年会 2000)
Works (2):
  • Research of proarrhythmic effects of drugs
    2000 -
  • Effects of Cilnidipine on the ECG of Chronic AV Block Dogs
    2002 -
Education (2):
  • - 1986 Yamanashi Medical University Faculty of Medicine
  • - 1990 Yamanashi Medical University Graduate School, Division of Medicine
Professional career (1):
  • Doctor of Medical Science (Yamanashi Medical University)
Work history (3):
  • 1992 - 1994 Yamanashi Medical University, Assistant Professor
  • 1994 - 1996 Yamanashi Medical University, Associate Professor
  • 2002 - 2002 University of Yamanashi, Associate Professor
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