Research field (2)：
Emergency medicine
, Pharmacology
Research keywords (8)：
Safety Pharmacology
, Cardiovascular Pharmacology
, Proarrhythmia model
, Cardiac sudden death
, torsade de pointes
, Drug-induced long QT syndrome
, 多能性幹細胞
, Prevention and treatment of lethal ventricular arrhythmias
Research theme for competitive and other funds (28)：
Koki Chiba, Ryuichi Kambayashi, Mayu Onozato, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Koichiro Tanaka, Yasunari Kanda, Takeshi Fukushima, et al. Imatinib induces diastolic dysfunction and ventricular early-repolarization delay in the halothane-anesthetized dogs: Class effects of tyrosine kinase inhibitors. Journal of Pharmacological Sciences. 2022
Yoshinori Takei, Yoko Amagase, Keiko Iida, Tomohiro Sagawa, Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Shinichi Kawai, Atsushi Sugiyama, et al. Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory. GeroScience. 2022
Karkhanis AV, Venkatesan G, Kambayashi R†, Leow JWH, Han MQ, Izumi-Nakaseko H†, Goto A†, Pang JKS, Soh BS, Kojodjojo P, et al. Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts. Acta pharmaceutica Sinica B. 2022. 12. 10. 3905-3923
Ryuichi Kambayashi, Ai Goto, Mayu Onozato, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Takeshi Fukushima, Atsushi Sugiyama. Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2022. 148. 1. 179-186
Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Kazuya Tsurudome, Hironori Ohshiro, Taku Izumi, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryota Nishiyama, Satomi Oyama, et al. Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses. Frontiers in Pharmacology. 2021. 12
Goto A†, Sakamoto K, Hagiwara-Nagasawa M†, Kambayashi R†, Chiba K†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Sugiyama A*†. In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys. Journal of Pharmacological Sciences. 2020. 143. 4. 272-280
Effect of negative expiratory airway pressure on the systemic circulation: a new strategy to salvage patients with cardiogenic shock.
(第84回日本循環器学会学術集会, Asian Pacific Society of Cardiology Congress 2020 2020)
How the deuteration of dronedarone can Modify its cardiovascular profile: a new strategy for optimizing efficacy and adverse effects.
(第84回日本循環器学会学術集会, Asian Pacific Society of Cardiology Congress 2020 2020)
Development of cardiotoxicity assessment method for molecularly targeted drugs in mice: from the viewpoint of cardio-oncology.
(第47回日本毒性学会学術年会 2020)
Reverse translational study on electropharmacological profile and proarrhythmic potential of azithromycin: azithromycin by itself will not induce torsade de pointes.
(Cardiac Safety London 2020 2020)
