Research field (2)：
Emergency medicine
, Pharmacology
Research keywords (8)：
Safety Pharmacology
, Cardiovascular Pharmacology
, Proarrhythmia model
, Cardiac sudden death
, torsade de pointes
, Drug-induced long QT syndrome
, 多能性幹細胞
, Prevention and treatment of lethal ventricular arrhythmias
Research theme for competitive and other funds (30)：
Hiroko Izumi-Nakaseko, Yuko Sekino, Ryuichi Kambayashi, Ai Goto, Yoshinori Takei, Yukiko Himeno, Ayako Okado-Matsumoto, Yoshinobu Nagasawa, Atsuhiko T Naito, Yasunari Kanda, et al. Nilotinib impairs relaxation and temporal electro-mechanical integrity in human iPS-derived cardiomyocyte sheets. Toxicology and applied pharmacology. 2025. 496. 117258-117258
Noboru Kaneko, Christopher M. Loughrey, Godfrey Smith, Ryuko Matsuda, Tomoko Hasunuma, Patric B. Mark, Masashi Toda, Makoto Shinozaki, Naoyuki Otani, Scott Kayley, et al. A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic actions: Preclinical and phase I study. BRITISH JOURNAL OF PHARMACOLOGY. 2024. 181. 18. 3401-3419
Ryuichi Kambayashi, Ai Goto, Akira Takahara, Hiroyuki Saito, Hiroko Izumi-Nakaseko, Yoshinori Takei, Yasuki Akie, Masaaki Hori, Atsushi Sugiyama. Characterization of remodeling processes in the atria of atrioventricular block dogs: Utility as an early-stage atrial fibrillation model. Journal of pharmacological sciences. 2024. 156. 1. 19-29
Atsushi Sugiyama, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akira Takahara, Ryuichi Kambayashi. Drug-induced long QT syndrome: Concept and non-clinical models for predicting the onset of drug-induced torsade de pointes in patients in compliance with ICH E14/S7B guidance. The Journal of pharmacology and experimental therapeutics. 2024
Ayano Satsuka, Alexandre J S Ribeiro, Hiroyuki Kawagishi, Shota Yanagida, Naoya Hirata, Takashi Yoshinaga, Junko Kurokawa, Atsushi Sugiyama, David G Strauss, Yasunari Kanda. Contractility assessment using aligned human iPSC-derived cardiomyocytes. Journal of pharmacological and toxicological methods. 2024. 128. 107530-107530
Goto A†, Kambayashi R†, Hagiwara-Nagasawa M†, Izumi-Nakaseko H†, Takei Y†, Kawai S†, Matsumoto A†, Lurie K, Sugiyama A*†. Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs. Heart and vessels. 2022. in press
Kambayashi R†, Goto A†, Izumi-Nakaseko H†, Matsumoto A†, Sugiyama A*†. Measurement of early and late repolarization periods in addition to QT interval to help predict the torsadogenic risk of donepezil based on reverse translational animal research on its proarrhythmic potential. Circulation Reports. 2021. 3. 9. 555-556
Hagiwara-Nagasawa M†, Kambayashi R†, Goto A†, Chiba K†, Wada T†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Lurie KG, et al. Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano-physiology and potential application. The Journal of Physiological Sciences. 2021. in press
Effect of negative expiratory airway pressure on the systemic circulation: a new strategy to salvage patients with cardiogenic shock.
(第84回日本循環器学会学術集会, Asian Pacific Society of Cardiology Congress 2020 2020)
How the deuteration of dronedarone can Modify its cardiovascular profile: a new strategy for optimizing efficacy and adverse effects.
(第84回日本循環器学会学術集会, Asian Pacific Society of Cardiology Congress 2020 2020)
Development of cardiotoxicity assessment method for molecularly targeted drugs in mice: from the viewpoint of cardio-oncology.
(第47回日本毒性学会学術年会 2020)
Reverse translational study on electropharmacological profile and proarrhythmic potential of azithromycin: azithromycin by itself will not induce torsade de pointes.
(Cardiac Safety London 2020 2020)
