Rchr

J-GLOBAL ID：200901008684049541 Update date: Oct. 27, 2024

SHINJI DEGUCHI

デグチシンジ | SHINJI DEGUCHI

Affiliation and department：
Other affiliations (2)：

Osaka University Global Center for Medical Engineering and Informatics Associate Center Director
Osaka University R3 Institute of Newly-Emerging Science Design, Osaka University Associate Center Director

Homepage URL (2)： http://mbm.me.es.osaka-u.ac.jp , http://mbm.me.es.osaka-u.ac.jp/en/

Research field (2)： Machine materials and mechanics , Biomedical engineering

Research keywords (4)：バイオメカニクス , 分子生体医工学 , 物理生物学 , 生物物理学

Research theme for competitive and other funds (30)：

2023 - 2028 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営
2023 - 2027 A myokine network that determines skeletal muscle quality
2021 - 2024 Mechanisms of cellular tensional homeostasis: measurement and analysis
2019 - 2023 Quantitative evaluation of cell-substrate interactions
2018 - 2023 運動の恩恵効果が骨格筋から分泌されるマイオカインによって媒介されることの証明

2018 - 2022 International collaborative research for liquid biopsy and precision medicine by microfluidic technologies to extracellular vesicles

2018 - 2021 Study of focal adhesions as a force-bearing cell organelle

2017 - 2021 Establishment of myotube contractile force and the molecular mechanisms underlying muscle atrophy

2016 - 2019 Drug screening using a newly developed cell assay

2015 - 2018 Development of cell contraction assay

2014 - 2017 3D microstructure of actin stress fibers

2013 - 2016 Development of new techniques for artificial control of cellular functional response and its application to biomedical engineering

2013 - 2015 3階層(分子・細胞・細胞集団)の力学環境をそれぞれ人為的制御する技術の開発と応用

2013 - 2015 What is the molecular mechanism of stress fiber disassembly caused by cyclic stretch?

2012 - 2015 Transient/sustained activation of pro-inflammatory signaling that depends on cellular mechanical forces

2012 - 2015 Mechanisms of cellular tensional homeostasis

2008 - 2012 Study of Mechanisms of Cellular Mechanosensing

2010 - 2011 非筋細胞における力学的ホメオスタシスの発現メカニズムの解明

2009 - 2011 Relationship between Biophysical Properties and Microstructure of Actin Stress Fibers

2008 - 2010 Study of long existence of single micro-bubble in liquid by the suppression of gas diffusion

2007 - 2008 Development of a vocal fold evaluation system based on the self-excitation mechanism

2006 - 2007 Study offlow electrification in pulsating flow

2006 - 2007 Biomechanics on Remodeling of Biological Tissues - Role of Collagen Cross-Linking

2005 - 2007 Study of roles of cytoskeletons in morphological responses of vascular endothelial cells to mechanical stimuli

2005 - 2006 血管内皮細胞ストレスファイバの機械-化学信号変換機能の定量的評価

2005 - 2006 細胞内ストレスファイバの力学特性計測と変形機構の解明

2003 - 2006 Mechanical dynamics of focal adhesions of vascular endothelial cells using nano-imaging

2004 - 2005 多光子型顕微鏡を用いた独自実験系による個別単球の内皮下浸潤動態の時系列3次元解析

2003 - 2005 Microbiomechanical studies on biological tissue/cell interaction and remodeling

2002 - 2004 Roles of Integrins of Endothelial Cells in Response to Mechanical Stimuli

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Papers (116)：

Honghan Li, Shiyou Liu, Shinji Deguchi, Daiki Matsunaga. Diffusion model predicts the geometry of actin cytoskeleton from cell morphology. PLOS Computational Biology. 2024. 20. 8. e1012312-e1012312
Aria Buenaventura, Takumi Saito, Taiga Kanao, Daiki Matsunaga, Tsubasa S. Matsui, Shinji Deguchi. Intracellular Macromolecular Crowding within Individual Stress Fibers Analyzed by Fluorescence Correlation Spectroscopy. Cellular and Molecular Bioengineering. 2024
Shihang Ding, Shinji Deguchi, Taeyoon Kim. Unraveling a Key Molecular Player Governing Pulmonary Alveolar Development. American journal of respiratory cell and molecular biology. 2024. 70. 4. 237-238
Yuika Ueda, Daiki Matsunaga, Shinji Deguchi. Asymmetric response emerges between creation and disintegration of force-bearing subcellular structures as revealed by percolation analysis. Integrative biology : quantitative biosciences from nano to macro. 2024. 16
Yuika Ueda, Daiki Matsunaga, Shinji Deguchi. Mutual interplay of actin meshwork and stress fibers in cellular adaptive response: Insights from percolation dynamics. 2023

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MISC (179)：

出口真次, 李泓翰, 松永大樹, 松井翼. 細胞発生力顕微鏡:画像から細胞の力学を予測する. 生物物理. 2022. 62. 4
上田唯花, 松永大樹, 松井翼, 出口真次. Theoretical consideration of the length distribution of actin filaments in cells. 日本機械学会バイオフロンティア講演会講演論文集(CD-ROM). 2020. 31st
上田唯花, 松永大樹, 松井翼, 出口真次. Thermodynamic consideration of tensional homeostasis in stress fibers. バイオエンジニアリング講演会講演論文集(CD-ROM). 2019. 32nd
出口真次, 松井翼, 市川尚文, 木岡紀幸. 細胞収縮力アッセイ. 月刊「細胞」. 2019. 51. 3. 39-42
出口真次, 松井翼, 市川尚文, 木岡紀幸. 細胞収縮力のアッセイ-メカノバイオロジー研究のツール. 月刊Precision Medicine. 2018. 1. 1. 108-111

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Patents (4)：

振動体観察方法,振動体観察装置,声帯観察装置及び声帯観察プログラム
音声の基本周波数検出方法及び声帯特性評価装置
振動体観察方法,振動体観察装置,声帯観察装置及び声帯観察プログラム
音声の基本周波数検出方法及び声帯特性評価装置

Books (8)：

Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissue
Cambridge University Press 2010
TRIBUTES TO YUAN-CHENG FUNG ON HIS 90TH BIRTHDAY Biomechanics: From Molecules to Man
World Scientific 2009
Proceedings of the Tohoku University Global Centre of Excellence Programme
2009
TRIBUTES TO YUAN-CHENG FUNG ON HIS 90TH BIRTHDAY Biomechanics: From Molecules to Man
World Scientific 2009
Future Medical Engineering Based on Bionanotechnology
Imperial College Press 2007

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Works (9)：

生細胞・生体分子用マイクロ力学試験装置の開発
2011 -
声帯自励振動の発生メカニズムに基づいた非接触的声帯物性評価方法の開発
2009 - 2010
肺コンプライアンスの新しい非侵襲的計測方法の開発と実用化
2009 - 2010
声帯自励振動のメカニズムの解明とそれに基づいた新しい声帯物性検査法の開発
2007 - 2008
病的な異常声帯の簡易可視化方法の開発と実用化
2007 - 2008

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Education (3)：

2001 - 2004 Tohoku University Graduate School of Engineering
1999 - 2001 Nagoya University Graduate School of Engineering Aerospace Engineering
1995 - 1999 Nagoya University Graduate School of Engineering Aerospace Engineering

Professional career (1)：

Ph. D. (Tohoku University)

Work history (6)：

2016/04 - 現在 Osaka University
2013/04 - 2016/03 Nagoya Institute of Technology
2011/04 - 2013/03 Tohoku University
2008/10 - 2011/03 Tohoku University
2007/09 - 2008/09 Tohoku University Associate Professor

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Awards (9)：

2018/04 - 日本機械学会賞(論文)
2011 - 日本機械学会バイオエンジニアリング部門瀬口賞
2011 - 第21回トーキン科学技術振興財団研究奨励賞
2008 - 日本機械学会賞(論文)
2007 - 日本機械学会奨励賞(研究)

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