Hide Izumi

ヒデイズミ | Hide Izumi

Affiliation and department：

Research keywords (2)： Purinergic sigaling , neuroinfammation

Research theme for competitive and other funds (12)：

2018 - 2020 高貪食能ミクログリアサブセットによるニューロン貪食の機序と神経疾患治療への適用
2015 - 2017 Purinergic regulation of dying cell phagocytosis and production of inflammatory and protective factors by microglia
2013 - 2015 Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.
2012 - 2014 Functional analysis of TLR4-activated long-lived microglia and their neuroprotective effects.
2012 - 2013 Development of screening methods to find novel therapeutic drugs for neurodegenerative disease using fluorescence-based probe and high-content microscope.

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Papers (50)：

Masuda, Shun, Tanaka, Shigeru, Shiraki, Hiroko, Sotomaru, Yusuke, Harada, Kana, Hide, Izumi, Kiuchi, Yoshiaki, Sakai, Norio. GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice. NEUROBIOLOGY OF DISEASE. 2022. 172
Shiraki, Hiroko, Tanaka, Shigeru, Guo, Yun, Harada, Kana, Hide, Izumi, Yasuda, Tomoharu, Sakai, Norio. Potential role of inducible GPR3 expression under stimulated T cell conditions. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2022. 148. 3. 307-314
Tanaka, Shigeru, Shimada, Naoto, Shiraki, Hiroko, Miyagi, Tatsuhiro, Harada, Kana, Hide, Izumi, Sakai, Norio. GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons. MOLECULAR AND CELLULAR NEUROSCIENCE. 2022. 118
Hirakawa, Haruki, Taguchi, Kei, Murakawa, Seiya, Asano, Masaya, Noguchi, Soma, Kikkawa, Satoshi, Harada, Kana, Adachi, Naoko, Ueyama, Takehiko, Hide, Izumi, et al. Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2022. 148. 1. 187-195
Zemgulyte, Gintare, Tanaka, Shigeru, Hide, Izumi, Sakai, Norio, Pampuscenko, Katryna, Borutaite, Vilmante, Rastenyte, Daiva. Evaluation of the Effectiveness of Post-Stroke Metformin Treatment Using Permanent Middle Cerebral Artery Occlusion in Rats. PHARMACEUTICALS. 2021. 14. 4

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Lectures and oral presentations (78)：

PC12細胞分化により発現誘導するGPR3はプレシナプス機能を修飾する
(第94回日本薬理学会年会 2021)
P2Y2受容体・PYK2シグナルを介したミクログリアの死細胞貪食の制御
(第94回日本薬理学会年会 2021)
E3ユビキチンリガーゼHRD1はセロトニントランスポーター機能を制御する
(第94回日本薬理学会年会 2021)
セロトニントランスポーターのS-パルミトイル化
(第59回日本薬学会 2020)
セロトニントランスポーターのS-パルミトイル化とその役割
(第138回日本薬理学会近畿部会 2020)

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