Rchr
J-GLOBAL ID:200901009077967287   Update date: May. 03, 2020

Hitomi Kiyotaka

Hitomi Kiyotaka
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www.ps.nagoya-u.ac.jp/lab_pages/biochemistry/newpage2.html
Research field  (1): Applied biochemistry
Research keywords  (2): fibrosis ,  transglutaminase
Research theme for competitive and other funds  (5):
  • 2011 - 2014 Molecular characterization of protein cross-linking reaction for cellular functions
  • 2011 - 2013 Studies on utitlities of high reactivity substrate peptides for glue-peptide
  • 2008 - 2011 Multiple application of cross-linking enzyme activity in life science
  • 2005 - 2007 Molecular basis of formation of corneocyte in skin epidermis
  • 2000 - 2002 Analysis of activation mechanism of transglutaminase in skin epidermis
Papers (104):
  • Yuki Tanabe, Miki Yamane, Manami Kato, Hirofumi Teshima, Miki Kuribayashi, Hideki Tatsukawa, Hiroyuki Takama, Masashi Akiyama, Kiyotaka Hitomi. Studies on differentiation-dependent expression and activity of distinct transglutaminases by specific substrate peptides using three-dimensional reconstituted epidermis. The FEBS journal. 2019. 286. 13. 2536-2548
  • Yoshimasa Ito, Hideki Tatsukawa, Hisateru Yamaguchi, Kazuo Takahashi, Kiyotaka Hitomi, Yukio Yuzawa. Detection and identification of potential transglutaminase 2 substrates in the mouse renal glomeruli. Archives of biochemistry and biophysics. 2018. 660. 11-19
  • Kojima Takaaki, Hata Jumpei, Oka Hiroya, Hayashi Kenta, Hitomi Kiyotaka, Nakano Hideo. Spatial arrangement of proteins using scCro-tag: application for an in situ enzymatic microbead assay. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2018. 82. 11. 1911-1921
  • Ivana Mižíková, Tilman Pfeffer, Claudio Nardiello, David E Surate Solaligue, Heiko Steenbock, Hideki Tatsukawa, Diogo M Silva, István Vadász, Susanne Herold, Richard J Pease, Siiri E Iismaa, Kiyotaka Hitomi, Werner Seeger, Jürgen Brinckmann, Rory E Morty. Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia. The FEBS journal. 2018. 285. 16. 3056-3076
  • Tatsukawa H, Nakagawa H, Hitomi K. ISOZYME-SPECIFIC IDENTIFICATION AND CHARACTERIZATION OF SUBSTRATES CROSSLINKED BY TRANSGLUTAMINASES IN LIVER FIBROSIS. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 2018. 42. 33A-33A
more...
MISC (10):
  • Qi Meng, Yuko Watanabe, Risa Suzuki, Rina Oguri, Hideki Tatsukawa, Kiyotaka Hitomi. Transglutaminase orthologues for medaka fish research model- biochemical characterization and establishment of gene-deficient mutants. Analytical biochemistry. 2020. 113610-113610
  • Hirofumi Teshima, Manami Kato, Hideki Tatsukawa, Kiyotaka Hitomi. Analysis of the expression of transglutaminases in the reconstructed human epidermis using three-dimensional cell culture. Analytical biochemistry. 2020. 113606-113606
  • 伊藤辰将, 辰川英樹, 山口央輝, 高橋和男, 人見清隆, 湯澤由紀夫. 糸球体腎炎に関わるタンパク質架橋化酵素の機能解明に向けた基礎的研究. 日本腎臓学会誌. 2019. 61. 3. 340
  • 伊藤辰将, 伊藤辰将, 辰川英樹, 山口央輝, 高橋和男, 人見清隆, 湯澤由紀夫. マウス腎糸球体内で架橋される組織型トランスグルタミナーゼ基質候補タンパク質の網羅的解析. JSBMS Letters. 2018. 43. Supplement. 104-104
  • Tatsukawa Hideki, Nakagawa Haruka, Kiyotaka Hitomi. Global identification and analysis of isozyme-specific substrates crosslinked by transglutaminases in mouse liver fibrosis. HEPATOLOGY. 2017. 66. 222A-222A
more...
Books (11):
  • The status quo in Enzyme Application to Food Sceience and Biotechnology
    2019
  • Preferred Substrate Structure of Transglutaminases
    Springer 2016 ISBN:9784431558231
  • Identification and application of the preferred substrate peptides for transglutaminases
    2009
  • *Preferred substrate sequences for transglutaminase 2: screening using a phage-displayed peptide library
    Amino Acids, 2009
  • Animal Cell Technology 15:Characterization of highly reactive sequences for transglutaminase 2 and factor XIIIa
    Kluwar Academic Publishers 2008
more...
Education (1):
  • 1986 - 1989 Kyoto University Graduate School, Division of Agriculture Food Science and Chemistry
Work history (9):
  • 2012/04/01 - 現在 Nagoya University Professor
  • 2013/04 - 2017/03 Nagoya University
  • 2012/04/01 - 2013/03/31 Nagoya University
  • 2007/04/01 - 2012/03/31 Nagoya University Associate professor
  • 2007/04/01 - Nagoya University
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Association Membership(s) (1):
JApan Society for Cell Biology
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