Jianguo Gu

グチエゴ | Jianguo Gu

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.tohoku-mpu.ac.jp/laboratory/drg/index.html

Research field (4)： Neuroscience - general , Pathobiochemistry , Pharmaceuticals - health and biochemistry , Tumor biology

Research keywords (7)：脳神経機能 , 固形ガンと血液ガン , 膜受容体 , 細胞シグナル伝達 , がん転移•浸潤 , 細胞接着・増殖・移動 , 糖タンパク質糖鎖

Research theme for competitive and other funds (31)：

2023 - 2027 糖転移酵素GnT-IIIによるがんの薬剤耐性の制御とその分子機序の解明
2022 - 2025 Elucidation of molecular mechanism for IgG levels regulated by L-fucose
2019 - 2023 Functions of glycosylation in integrin-mediated outside-in and inside-out signaling
2020 - 2022 Functional analysis of sialylation on sorting zones of membrane glycoproteins
2018 - 2021 Modulation of cancer cells by core fucose-specific antibody

2018 - 2020 糖鎖修飾によるインテグリンの選別輸送ゾーンの制御とその分子機序の解明

2015 - 2019 Analysis of sialylation on cell biological functions

2015 - 2017 Anticancer effects based on core fucose

2012 - 2014 コアフコースの機能と神経疾患との関連性について

2009 - 2014 Change of oligosaccharides in cell adhesion, and its roles

2011 - 2013 Liver regeneration is dependent on sugar chain

2010 - 2011 脳神経系におけるα1,6フコース構造の役割

2006 - 2007 Functional analysis of effects of N-glycans on membrane recnpthrs and their associations

2004 - 2005 The roles of N-glycans in complex formation of integrins and growth factor receptors.

2003 - 2005 Regulatory mechanisms of ligand binding and signaling events of laminin-binding integrins

2001 - 2005 Integrated analyses of biological functions of sugar chains : Glycomics

2003 - 2003 細胞外基質因子による腫瘍血管新生の制御機構の解析

2003 - 2003 インテグリン糖鎖の改変による癌転移・浸潤の制御とその分子メカニズムの解析

2002 - 2003 基底膜による上皮組織の形成および再生の制御機構

2002 - 2003 Studies on integrinα3β1-mediated signaling

2000 - 2002 Studies on the Regulatory Mechanisms and Molecular Diversity of Integrinmediated Signal Transduction

2001 - 2001 細胞外基質によるがん細胞の機能制御機構

2000 - 2001 基底膜型インテグリンを介するシグナル伝達における癌抑制因子PTEN役割

1999 - 2001 Engineering of Artificial Biomatrix through Extracellular Matrix Targeting of Functional Proteins

1999 - 1999 基底幕による細胞機能制御の分子的基盤の解明

1998 - 1999 SIGNAL TRANSDUCTION BY INTEGRIN-MATRIX INTERACTION

1998 - 1999 MECHANISMS AND VARIATIONS OF INTEGRIN-MEDIATED SIGNAL TRANSDUCTION

1995 - 1995 細胞外マトリックス形成や増殖因子の機能制御に関わるプロテオグリカンの役割

1994 - 1994 CDG症候群の病因遺伝子の解析

1994 - 1994 ニューロフィラメントにおける糖鎖付加修飾の機能的意義の解析

1993 - 1993 糖鎖欠損糖蛋白症候群の病因解析とオリゴ糖転移酵素のクローニング

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Papers (160)：

Jianwei Liu, Tomoya Isaji, Sachiko Komatsu, Yuhan Sun, Xing Xu, Tomohiko Fukuda, Tsutomu Fujimura, Shinichiro Takahashi, Jianguo Gu. BRCC36 associates with FLT3-ITD to regulate its protein stability and intracellular signaling in acute myeloid leukemia. Cancer science. 2024
Tiantong Wang, Zhiwei Zhang, Changduo Qu, Wanli Song, Ming Li, Xiaoguang Shao, Tomohiko Fukuda, Jianguo Gu, Naoyuki Taniguchi, Wenzhe Li. Core fucosylation regulates the ovarian response via FSH receptor during follicular development. Journal of advanced research. 2024
Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya. Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit. Biomolecules. 2023. 13. 12. 1752-1752
Xing Xu, Tomohiko Fukuda, Jun Takai, Sayaka Morii, Yuhan Sun, Jianwei Liu, Shiho Ohno, Tomoya Isaji, Yoshiki Yamaguchi, Miyako Nakano, et al. Exogenous L-fucose attenuates neuroinflammation induced by lipopolysaccharide. The Journal of biological chemistry. 2023. 105513-105513
Noriko Kanto, Yuki Ohkawa, Masato Kitano, Kento Maeda, Masafumi Shiida, Tatsuya Ono, Fumi Ota, Yasuhiko Kizuka, Kei Kunimasa, Kazumi Nishino, et al. A highly specific antibody against the core fucose of the N-glycan in IgG identifies the pulmonary diseases and its regulation by CCL2. The Journal of biological chemistry. 2023. 299. 12. 105365-105365

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MISC (71)：

新居瞳, 鎌田佳宏, 赤松佑香, 前田恵, 福田友彦, 顧建国, 三善英知. コアフコシル化を欠損した肝細胞由来の細胞外小胞では、インテグリンα3β1が増加した. 日本癌学会総会記事. 2017. 76回. P-1167
Jianguo Gu, Jishun Lu, Sanghun Im, Tomohiko Fukuda, Noritaka Hashii, Daisuke Takakura, Nana Kawasaki, Tomoya Isaji. Functional analysis of the expression of N-glycans in epithelial-mesenchymal transition: Importance of alpha 2,6 sialylation. GLYCOBIOLOGY. 2014. 24. 11. 1177-1177
Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Eiji Miyoshi, Naoyuki Taniguchi, Yoshitaka Ikeda. Fucosyltransferase 8. GDP-fucose N-glycan core α6-fucosyltransferase (FUT8). Handbook of Glycosyltransferases and Related Genes, Second Edition. 2014. 1. 581-596
Yoshitaka Ikeda, Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Naoyuki Taniguchi. Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (MGAT3); β1,4-NAcetylglucosaminyltransferase III (GnT-III, GlcNAcT-III). Handbook of Glycosyltransferases and Related Genes, Second Edition. 2014. 1. 209-222
Tomoya Isaji, Sanghun Im, Tomohiko Fukuda, Jianguo Gu. GOLPH3 regulates integrin-mediated biological functions via up-regulation of sialylation. GLYCOBIOLOGY. 2013. 23. 11. 1336-1336

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Education (1)：

- 1993 Osaka University Graduate School of Medicine

Professional career (1)：

(BLANK)

Work history (8)：

2019/04 - 現在東北医科薬科大学分子生体膜研究所所長
2016 - 現在東北医科薬科大学薬学部教授
2006/04 - 2015 東北薬科大学教授
2004/01 - 2006/03 大阪大学大学院医学部助教授
2002/10 - 2003/12 大阪大学大学院医学部講師

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Association Membership(s) (8)：

米国糖鎖生物学会 , JAPAN SOCIETY FOR CELL BIOLOGY , THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , 日本癌学会 , 日本血液学会 , 肝細胞研究会

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