Rchr
J-GLOBAL ID:200901009625840142   Update date: Sep. 01, 2020

Ito Shingo

イトウ シンゴ | Ito Shingo
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): http://www.ohtsuki-lab.jp/
Research field  (1): Clinical pharmacy
Research keywords  (5): Drug delivery system ,  Cell penetrating peptide ,  Blood-brain barrier ,  トランスポーター ,  Transporter
Research theme for competitive and other funds  (24):
  • 2020 - 2021 血液脳関門透過環状ペプチドを用いたバイオ医薬品の脳内送達技術の開発
  • 2019 - 2021 肥満を伴わない糖尿病発症におけるオーファントランスポーターの関与
  • 2019 - 2020 血液脳関門透過環状ペプチドを用いた抗体医薬の脳内送達技術の基盤構築
  • 2019 - 2020 抗体医薬による神経変性疾患治療のための脳関門透過技術の開発
  • 2019 - 2020 高脂肪食による血液脳関門破綻と認知症機能低下の組織連関の解明
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Papers (44):
  • Seiryo Ogata, Shingo Ito, Takeshi Masuda, Sumio Ohtsuki. Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet. Pharmaceutical research. 2019. 36. 10. 141-141
  • Takeshi Masuda, Toshiki Hoshiyama, Tatsuki Uemura, Mio Hirayama-Kurogi, Seiryo Ogata, Arisu Furukawa, Pierre-Olivier Couraud, Tomomi Furihata, Shingo Ito, Sumio Ohtsuki. Large-Scale Quantitative Comparison of Plasma Transmembrane Proteins between Two Human Blood-Brain Barrier Model Cell Lines, hCMEC/D3 and HBMEC/ciβ. Molecular pharmaceutics. 2019. 16. 5. 2162-2171
  • Takuya Kuno, Mio Hirayama-Kurogi, Shingo Ito, Sumio Ohtsuki. Proteomic analysis of small intestinal epithelial cells in antibiotic-treated mice: Changes in drug transporters and metabolizing enzymes. Drug metabolism and pharmacokinetics. 2019. 34. 2. 159-162
  • Shingo Ito, Gentaro Honda, Yu Fujino, Seiryo Ogata, Mio Hirayama-Kurogi, Sumio Ohtsuki. Knockdown of orphan transporter SLC22A18 impairs lipid metabolism and increases invasiveness of human hepatoma cells. Pharmaceutical research. 2019. 36. 3. 39
  • Ito S. [Elucidation of Disease Mechanisms Based on Transport Function at Tissue Barriers and Challenges in Drug Development]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2019. 139. 4. 497-503
more...
MISC (2):
Patents (6):
  • 血液脳関門透過性ペプチド
  • 膵がん等のがんの判定用バイオマーカー
  • 血液脳関門透過性ペプチド
  • 膵がん等のがんの判定用バイオマーカー
  • Novel cell membrane-permeating peptide
more...
Lectures and oral presentations  (91):
  • 神経変性疾患発症に関わる脳関門物質動態制御機構の解明と創薬への展開
    (日本薬物動態学会第34回年会 2019)
  • 小腸環状ペプチドを用いた経口インスリン開発
    (日本薬剤学会経口吸収フォーカスドグループ 2019)
  • Small-intestine permeable cyclic peptide DNP increases the oral insulin absorption in mice
    (AAPS2019, 2019)
  • Identification of cell-surface proteins internalized into in vitro human brain microvascular endothelial cells by SWATH-based quantitative proteomics,
    (BBB signaling 2019 2019)
  • 環状ペプチドを用いた組織関門透過技術の開発
    (第 32 回 ケミカルバイオロジー研究所セミナー 第 104 回 生物科学フロンティアセミナー (大阪府立大学) 2019)
more...
Education (2):
  • 2003 - 2006 Tohoku University
  • 2001 - 2003 Kyoto pharmaceutical University Clinical pharmaceutical Sciences
Professional career (1):
  • Pharmaceutical Sciences (Tohoku University)
Work history (6):
  • 2017/01 - 現在 Faculty of Life Sciences Kumamoto University Pharmaceutical Microbiology Associate Professor
  • 2012/04 - 2016/12 Faculty of Life Sciences Kumamoto University Pharmaceutical Microbiology Assistant Professor
  • 2010/04 - 2012/03 National Research Council Canada Institute for Biological Sciences Research Associate
  • 2012 - Assistant Professor, ,Faculty of Life Sciences(Pharmaceutical sciences group),Kumamoto University
  • 2007/11 - 2010/03 Tohoku University Graduate School of Pharmaceutical Sciences
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Awards (8):
  • 2019/12 - 日本薬物動態学会 奨励賞
  • 2019/07 - 日本プロテオーム学会 奨励賞
  • 2018/03 - outstanding performance award
  • 2017/11 - The pharmaceutical society of japan, Kyusyu branch Young Investigator Award
  • 2014/03 - 熊本大学国際先端研究拠点Encouragement Award
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Association Membership(s) (7):
日本プロテオーム学会 ,  Society for Neuroscience ,  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM ,  THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS ,  THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  日本血管生物医学会
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