Ito Shingo

イトウシンゴ | Ito Shingo

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.ohtsuki-lab.jp/

Research field (1)： Clinical pharmacy

Research keywords (6)： Oral biopharmaceutics , Orphan transporter , Drug delivery system , Cell-penetrating cyclic peptide , Blood-brain barrier , トランスポーター

Research theme for competitive and other funds (44)：

2023 - 2027 モダリティの組織選択的送達と経口吸収を可能にする創薬デザイン技術開発
2022 - 2026 組織関門透過ペプチドの輸送分子機序解明に基づくマクロトランスサイトーシスの同定
2023 - 2025 階層スフェロイド型血液脳関門モデルによる薬物脳送達キャリアのヒト脳移行性評価技術の開発
2023 - 2025 小腸透過環状ペプチド修飾インスリンアナログの開発
2022 - 2025 小腸透過環状ペプチドを用いたバイオ医薬の経口投与技術の開発

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Papers (80)：

Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido, Sumio Ohtsuki. Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease. Fluids and barriers of the CNS. 2023. 20. 1. 66-66
Yudai Hamada, Seiryo Ogata, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki. Development of a method for isolating brain capillaries from a single neonatal mouse brain and comparison of proteomic profiles between neonatal and adult brain capillaries. Fluids and barriers of the CNS. 2023. 20. 1. 50-50
Ryotaro Yagi, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki. Effect of antibiotic-administration period on hepatic bile acid profile and expression of pharmacokinetic-related proteins in mouse liver, kidney, and brain capillaries. Drug metabolism and pharmacokinetics. 2023. 50. 100494-100494
Ayano Mori, Takeshi Masuda, Shingo Ito, Sumio Ohtsuki. Human Hepatic Transporter Signature Peptides for Quantitative Targeted Absolute Proteomics: Selection, Digestion Efficiency, and Peptide Stability. Pharmaceutical research. 2022. 39. 11. 2965-2978
Yuki Yamasaki, Takashi Moriwaki, Seiryo Ogata, Shingo Ito, Sumio Ohtsuki, Genki Minegishi, Satoshi Abe, Yumi Ohta, Kanako Kazuki, Kaoru Kobayashi, et al. Influence of MDR1 gene polymorphism (2677G>T) on expression and function of P-glycoprotein at the blood-brain barrier: utilizing novel P-glycoprotein humanized mice with mutation. Pharmacogenetics and genomics. 2022. 32. 8. 288-292

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MISC (115)：

河田達哉, 西澤まど香, 近藤悠希, 山田侑世, 山田侑世, 竹尾透, 中潟直己, 東大志, 本山敬一, 有馬英俊, et al. Niemann-Pick病C型における2-hydroxypropyl-β-cyclodextrinの脳-肝連関の作用点の探索. 日本薬学会九州支部大会講演要旨集. 2021. 38th
増田豪, 伊藤慎悟, 石濱泰, 大槻純男. エチレングリコールを用いた細胞分画法とプロテオミクスへの応用. 生体膜と薬物の相互作用シンポジウム講演要旨集. 2021. 42nd (CD-ROM)
伊藤慎悟, 伊藤慎悟, 伊藤慎悟, 大石真梨子, 緒方星陵, 上村立記, COURAUD Pierre-Olivier, 増田豪, 増田豪, 増田豪, et al. 細胞膜タンパク質ビオチン標識法と網羅的タンパク質定量法を組み合わせたヒト脳毛細血管内皮細胞における細胞内内在化膜タンパク質の同定. 日本DDS学会学術集会プログラム予稿集. 2021. 37th
吉田尚功, 伊藤慎悟, 伊藤慎悟, 伊藤慎悟, 緒方星陵, 増田豪, 増田豪, 増田豪, 大槻純男, 大槻純男, et al. Comparative analysis of blood-brain barrier proteome in the mouse isolated capillaries between cerebrum and cerebellum. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. Effects of Loss of P-glycoprotein of blood-brain barrier homeostasis. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35th

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Patents (4)：

Novel cell membrane-permeating peptide
Cell membrane-permeating peptide
BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE
膵がん等のがんの判定用バイオマーカー

Lectures and oral presentations (162)：

ヒト脳毛細血管内皮細胞における細胞内内在化分子の同定
(第30回日本血管生物医学会 2022)
Diurnal changes in protein expression at the blood-brain barrier in mice
(2022)
IMPROVEMENT OF INSULIN ABSORPTION BY ORAL CO-ADMINISTRATION WITH SMALL INTESTINE-PERMEABLE CYCLIC PEPTIDE CONCATENATED WITH AN INSULIN-BINDING PEPTIDE
(2022)
インスリン抵抗性による脳関門タンパク質発現変動の解明
(第42回生体膜と薬物の相互作用シンポジウム 2022)
脳への中;高分子医薬送達を目指した血液脳関門透過研究
(日本薬剤学会第37年会 2022)

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Education (2)：

2003 - 2006 Tohoku University Graduate school of Pharmaceutical Sciences
2001 - 2003 Kyoto pharmaceutical University Graduate school of pharmaceutical sciences Clinical pharmaceutical Sciences

Professional career (1)：

Pharmaceutical Sciences (Tohoku University)

Work history (5)：

2018/01 - 現在 Faculty of Life Sciences Kumamoto University Pharmaceutical Microbiology Associate Professor
2012/04 - 2017/12 Faculty of Life Sciences Kumamoto University Pharmaceutical Microbiology Assistant Professor
2010/04 - 2012/03 National Research Council Canada Institute for Biological Sciences Research Associate
2007/11 - 2010/03 Tohoku University Graduate School of Pharmaceutical Sciences
2006/04 - 2007/10 Tohoku University Graduate School of Pharmaceutical Sciences

Committee career (4)：

2020/04 - 現在日本薬剤学会経口吸収フォーカスドグループ広報
2019/04 - 現在 Journal of Pharmaceutical Sciences Editorial Advisory Board
2014/04 - 2019/03 Journal of Pharmaceutical Sciences Scientific Advisor
2014/11 - 2015/11 第37回生体膜と薬物の相互作用シンポジウム事務局長

Awards (10)：

2022/04 - JST-CREST[細胞外微粒子] Young Innovator Award
2020/03 - American Pharmacists Association Ebert Prize
2019/12 - 日本薬物動態学会奨励賞
2019/07 - 日本プロテオーム学会奨励賞
2018/03 - outstanding performance award

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Association Membership(s) (7)：

日本プロテオーム学会 , Society for Neuroscience , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本血管生物医学会

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