Rchr

J-GLOBAL ID：200901009989330778 Update date: Sep. 03, 2024

Wada Hiroshi

ワダヒロシ | Wada Hiroshi

Affiliation and department：
Homepage URL (2)： http://web.tbgu.ac.jp/ait/wada/ , http://db.tohoku.ac.jp/whois/detail/b6669433b8717e8ca8124a5ee024cc9f.html

Research field (4)： Mechanics and mechatronics , Otorhinolaryngology , Biomaterials , Biomedical engineering

Research keywords (3)：聴覚 , 機械力学 , 生体医工学

Research theme for competitive and other funds (48)：

2016 - 2019 中耳・内耳疾患を診断できる計測装置SFIの開発
2011 - 2013 ペンドリン変異体の細胞内における機能回復過程の解明
2011 - 2013 Challenges of visualizing the conformational changes of prestin using an atomic force microscope equipped with a membrane potential control device
2010 - 2012 Regulation of the OHC cytoskeleton induced by lipid raft.-Effects of cholesterol alterations on hearing-
2008 - 2011 Creation of a New Method to Refold the Membrane Protein Mutants for Curing of Hereditary Hearing Loss

2008 - 2010 外有毛細胞に存在するモーター蛋白質プレスチンの変形量解析:一分子直接計測の試み

2007 - 2008 Mechanism of the hearing loss in Kendo players and development of a new protector

2007 - 2008 Lipid raftはOHC情報伝達を調節する-運動能における脂質の機能解明-

2006 - 2008 プレスチン結晶化の試み〜聴覚を鋭敏にしているモーター蛋白質の構造解明を目指して〜

2006 - 2008 Structural and functional analysis of the motor protein prestin using purified protein

2003 - 2008 Biomechanics at Micro- and Nanoscale Levels

2003 - 2007 Structural analysis of the motor protein prestin

2005 - 2006 ソノポレーション法によるinvivoコルチ器へのprestin遺伝子導入

2005 - 2006 The Stiffness Change of Conditioning Effect in Inner Hair Cells

2005 - 2006 Pathophysiology and Treatment Strategy of the Intractable Patulous Eustachian Tube

2003 - 2005 原子間力顕微鏡によるヒト胃癌培養細胞における癌進行度評価の試み

2003 - 2004 器官培養コルチ器へのprestin遺伝子(pres)導入-prestinによる蝸牛増幅機構の直接的解析-

2003 - 2004 The New Accurate Diagnostic method and Treatment for the patulous Eustachian tube

2001 - 2003 Development of the program for analysis of the dynamic behavior of the organ of Corti

2001 - 2002 Development of a new electromagnetic hearing aid using lightweight coils to vibrate the ossicles via the tympanic membrane

2000 - 2002 Shock Dynamic Study of Laser Ablation Induced Drug Delivery

1999 - 2001 Development of hand-guided measurement device of stapes mobility using the micromachining technique

1999 - 2001 外有毛細胞のmotilityにより発生する力の計測

2000 - 2000 Inner Ear Function

1999 - 2000 The New Treatments for the Complications of Middle Ear Cholesteatoma

1999 - 2000 Analysis of the function of the protein motor within the outer hair cell motility

1999 - 2000 Determination of OHC protein motor

1999 - 1999 蝸牛外有毛細胞細胞膜モーター蛋白質のクローニングと細胞物理的特性

1998 - 1999 Development of Measurement method of Stapes Mobility

1996 - 1997 外有毛細胞可動メカニズムの数値シミュレーション

1995 - 1997 Vibration measurement of the tympanic membrane using electronic speckle pattern interferometry

1994 - 1996 Analysis of isolated outer hair cell motility in response to sound stimuli using high speed video system.

1994 - 1995 ダイナミックスによる耳音響放射発生機序の理論的解明

1993 - 1995 Development of Diagnostic Apparatus for Ear Disease

1993 - 1994 ダイナミックスによる歪成分耳音響放射発生機序の理論的解明とそのアニメーション表示

1993 - 1994 超音波による鼓膜物性値および鼓膜厚の測定手法の開発とその診断への応用

1992 - 1994 Development of measurement system for basilar membrane vibrations using a laser Doppler vibrometer coupled to a microscope.

1992 - 1993 ダイナミックスによる耳音響放射発生機序の理論的解明

1991 - 1992 数値シミュレ-ションによる耳音響放射発生機序の解明

1990 - 1991 Development of Animated Expression of Eardrum Vibration

1990 - 1991 耳音響放射と中耳動特性の相関

1989 - 1990 3次元表示可能な中耳病変診断測定システムの開発

1988 - 1989 セラミックス製人工耳小骨の最適設計に関する研究

1986 - 1987 可変加振振動数を有するティンパノメーターの開発

1986 - 1987 鼓膜振動特性による中耳病変推定法確立に関する研究

Visualization Technique for Measuring Dynamic Behavior in Nano Scale.

Diagnostic Apparatus for Measuring Stapes Mobility

Development of a New Electromagnetic Hearing Device

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Papers (233)：

Michio Murakoshi, Yuhi Koike, Shin Koyama, Shinichi Usami, Kazusaku Kamiya, Katsuhisa Ikeda, Yoichi Haga, Kohei Tsumoto, Hiroyuki Nakamura, Noriyasu Hirasawa, et al. Effects of salicylate derivatives on localization of p.H723R allele product of SLC26A4. Auris, nasus, larynx. 2022. 49. 928-937
Ryoukichi Ikeda, Shinji Hamanishi, Toshiaki Kikuchi, Hidetoshi Oshima, Yoshinobu Kawamura, Yusuke Kusano, Tetsuaki Kawase, Yukio Katori, Hiroshi Wada, Toshimitsu Kobayashi. Objective assessment of autophony during phonation in the diagnosis of patulous Eustachian tube patients. Auris, nasus, larynx. 2021. 48. 4. 738-744
Michio MURAKOSHI, Hiroshi WADA. Analysis of membrane structure of the inner ear motor protein prestin by force spectroscopy. Journal of Biomechanical Science and Engineering. 2021. 16. 3. 21-00125
Nattikan Kanka, Michio Murakoshi, Shinji Hamanishi, Risako Kakuta, Sachiko Matsutani, Toshimitsu Kobayashi, Hiroshi Wada. Longitudinal changes in dynamic characteristics of neonatal external and middle ears. International Journal of Pediatric Otorhinolaryngology. 2020. 134. 110061-110061
Murakoshi M, Wada H. Restoration of proper delivery to the cell membrane for pendrin mutants by salicylate derivatives. Proceedings of the 28th Annual Meeting of the Japan Otological Society, July 3-6, 2018, Osaka, O-161. 2018. 433-433

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MISC (24)：

WADA Hiroshi. Biomechanics at Micro- and Nanoscale Levels. Transactions of the Japanese Society for Medical and Biological Engineering : BME. 2008. 46. 1. 1-4
GOMI Takashi, SUGAWARA Michiko, WADA Hiroshi. Imaging of the Protein Motor 'Prestin' Located in the Lateral Wall of Outer Hair Cells by Atomic Force Microscopy. 2004. 2004. 16. 5-6
A. Toshimitsu Yokobori, Fumihiro Suzuki, Kazuhiko Usami, Hiroshi Kawamoto, Hiroshi Wada. The Characteristics of Fracture Strength of Alumina Ceramics With a Small Notch. JSFM. 2004. 38. 1. 1-6
MIYAMOTO Daisuke, SUGAWARA Michiko, WADA Hiroshi. Active Force Produced by the Motility of the Outer Hair Cell. 2002. 2002. 14. 235-236
SUGAWARA Michiko, WADA Hiroshi. Force Generated by the Motility of the Outer Hair Cell : Numerical Analysis by the Shell Model. 2002. 2002. 14. 301-302

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Patents (8)：

Measuring method, measuring apparatus and indication method of the dynamical characteristics of middle ear
中耳動特性測定用プローブ
中耳動特性表示法および中耳動特性測定装置
振動測定装置 (Apparatus of Vibration Measurement)
Measuring method, measuring apparatus and indication method of the dynamical characteristics of middle ear

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Books (49)：

生き物と音の辞典
朝倉書店 2019
聴覚検査の実際
南山堂 2017
生物学と医学のための物理学
共立出版 2015
Assessing Middle Ear Function in Infants
Plural Publishing 2011 ISBN:9781597563918
Assessing Middle Ear Function in Infants
Plural Publishing 2011 ISBN:9781597563918

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Lectures and oral presentations (194)：

Dynamic characteristics of the outer and middle ears in neonate
(33rd World Congress of Audiology 2016)
内・外有毛細胞のメカニクス
(日本音響学会2016年秋季研究発表会 2016)
Auditory Mechanics: 鼓膜から感覚細胞まで
(第16回山形ニューロサイエンス・医工学研究会 2015)
AFM imaging of the structure of the motor protein prestin purified and reconstituted into an artificial lipid bilayer
(The 4th Japan-Switzerland Workshop on Biomechanics 2014)
Shear motion in the organ of Corti opens and closes mechanoelectrical transduction channels located in the stereocilia of the sensory hair cells
(International Symposium on Mechanobiology 2014 2014)

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Works (36)：

生後5日以内診断可能な「新生児難聴スクリーニング装置」の実用化開発
2011 - 2012
生後5日以内診断可能な「新生児難聴スクリーニング装置」の実用化開発
2011 - 2012
マイクロポンプシステムを用いた分子シャペロンとして働く薬物投与による遺伝性難聴の革新的治療法の創生
2009 - 2012
マイクロポンプシステムを用いた分子シャペロンとして働く薬物投与による遺伝性難聴の革新的治療法の創生
2009 - 2012
MEMS/NEMS人工聴覚器による感音難聴治療法開発
2010 - 2011

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Education (3)：

1974 - 1977 Tohoku University
1972 - 1974 Tohoku University Graduate School, Division of Engineering
1968 - 1972 Tohoku University Faculty of Engineering

Professional career (1)：

工学博士 (東北大学)

Work history (13)：

2013/04 - 2021/03 Department of Intelligent Information Systems Professor
2015/04 - 2020/03 Tohoku Bunka Gakuen University Faculty of Science and Technology
2013/04 - 2015/03 Tohoku Bunka Gakuen University
1993 - 2013 Tohoku University Graduate School of Engineering
1993 - 2013 - Professor, Faculty of Engineering, Tohoku University

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Committee career (6)：

2016 - 現在科学技術振興機構専門委員
2015 - 2021 日本医療研究開発機構専門委員
2014 - 2021 日本学術振興会委員
1994 - 2016 日本聴覚医学会評議員
2000 - 2010 日本耳科学会評議員

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Awards (4)：

2011 - 日本機械学会功績賞
2003 - 日本機械学会業績賞
1998 - 日本機械学会賞(論文)
1991 - 日本機械学会論文賞

Association Membership(s) (22)：

日本工学アカデミー , 日本聴覚医学会 , 日本耳科学会 , 日本耳鼻咽喉科学会 , 日本ME学会 , 日本音響学会 , 日本機械学会 , International Society of Audiology , International Institute of Acoustics and Vibration , Acoustical Society of America , ARO (Association for Research in Otolaryngology) , 日本聴覚医学会 , 日本耳科学会 , 日本耳鼻咽喉科学会 , 日本ME学会 , 日本音響学会 , 日本機械学会 , International Society of Audiology , International Institute of Acoustics and Vibration , Biophysical Society , Acoustical Society of America , ARO (Association for Research in Otolaryngology)

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