Hirai Toyohiro

Affiliation and department：

Research field (1)： Respiratory medicine

Research theme for competitive and other funds (8)：

2020 - 2023 Cross-sectional and prospective study with metabolome analysis to detect pathophysiology about the relationship between deterioration in lung function and sleep disordered breathing
2015 - 2018 Application of iPS cell technology to lung regeneration and development of bioresource for elucidating the mechanisms of lung diseases
2010 - 2015 Researches using iPS cells on intractable respiratory diseases to elucidate their pathogenesis and develop novel therapy.
2010 - 2012 New system for quantitative analysis of chest CT images in pulmonary diseases
2008 - 2010 Analysis of Intra-cellular signaling pathway and gene network in acute lung injury as for therapeutic strategy.

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Papers (617)：

Yusuke Shima, Hironori Yoshida, Keiichiro Suminaga, Hiroshi Yoshida, Kentaro Hashimoto, Tatsuya Ogimoto, Kazutaka Hosoya, Hitomi Ajimizu, Tomoko Funazo, Takashi Nomizo, et al. Safety and efficacy of pemetrexed for patients with non-small cell lung cancer in the setting of renal impairment: a retrospective study. BMC Cancer. 2025. 25. 1
Naoya Tanabe, Hisako Matsumoto, Chie Morimoto, Toyohiro Hirai. Sputum short-chain fatty acids, microbiome, inflammation, and mucus plugging in obstructive airway disease. The Journal of allergy and clinical immunology. 2025
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Takahisa Kawaguchi, Kazuya Setoh, Tomoko Wakamura, Toyohiro Hirai, Kazuo Chin, Fumihiko Matsuda. Descriptive Epidemiology and Prognostic Significance of Diaphragm Thickness in the General Population: The Nagahama Study. Journal of cachexia, sarcopenia and muscle. 2025. 16. 1. e13690
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Takahisa Kawaguchi, Kazuya Setoh, Tomoko Wakamura, Toyohiro Hirai, Kazuo Chin, Fumihiko Matsuda. Intraindividual correlations between nocturnal urination frequency and sleep blood pressure: the Nagahama Study. Hypertension research : official journal of the Japanese Society of Hypertension. 2025
Kazuma Nagata, Susumu Sato, Kiyoshi Uemasu, Naoya Tanabe, Atsuyasu Sato, Shigeo Muro, Toyohiro Hirai. Trajectory of the arterial-alveolar oxygen gradient in COPD for a decade. PloS one. 2025. 20. 1. e0318377

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MISC (233)：

森令法, 半田知宏, 半田知宏, 大角明宏, 池添浩平, 谷澤公伸, 魚住龍史, 田辺直也, 田辺直也, 小熊毅, et al. CTを用いた肺移植患者の骨密度の低下とその関連因子の検討. 日本肺および心肺移植研究会プログラム・抄録集. 2024. 40th
吉田博徳, 橋本健太郎, 吉田寛, 味水瞳, 糸谷涼, 阪森優一, 小笹裕晃, 平井豊博. PD-L1高発現のSTK11/TP53/KRAS変異陽性肺腺癌に対して免疫チェックポイント阻害剤を投与した症例. 気管支学. 2023. 45
住永圭一郎, 吉田博徳, 名取大輔, 島佑介, 味水瞳, 野溝岳, 小笹裕晃, 阪森優一, 阪森優一, 吉岡正博, et al. 当院における胸部悪性腫瘍に対するComprehensive Genomic Profilingの有用性の検証. 日本肺癌学会学術集会号. 2023. 64th (CD-ROM)
白石祐介, 田辺直也, 前谷知毅, 張怡, 坂本亮, 鍛冶静雄, 池添浩平, 谷澤公伸, 小熊毅, 室繁郎, et al. Quantitative CT analyses of Interstitial Lung Abnormality in patients with COPD. 日本呼吸器学会誌(Web). 2023. 12
Masatoshi Yamazoe, Hiroaki Ozasa, Tatsuya Ogimoto, Kazutaka Hosoya, Hitomi Ajimizu, Tomoko Yamamoto, Takahiro Tsuji, Ryo Itotani, Yuichi Sakamori, Takashi Nomizo, et al. TEAD single nucleotide polymorphism affects PFS in EGFR-mutation positive lung cancer patients treated with EGFR TKIs. CANCER SCIENCE. 2022. 113. 1014-1014

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