Sakurai Fuminori

サクライフミノリ | Sakurai Fuminori

Affiliation and department：

Research field (3)： Clinical pharmacy , Pathobiochemistry , Pharmacology

Research keywords (2)： Gene Therapy, DDS, Biopharmaceutics, Pharmacokinetics , Gene Therapy

Research theme for competitive and other funds (24)：

2024 - 2028 Efficient Drug Targeting by oncolytic virus-meidated tumor-specific expression of artificial receptors
2021 - 2025 難治性がん治療用デザイナー細菌の開発
2022 - 2024 血管を経由する新発想での臓器の脱線維化技術の開発
2021 - 2024 A study of drug repurposing of oncolytic virus for idiopathic pulmonary fibrosis
2021 - 2024 Elucidation of oncolytic virus-mediated intratumorl infiltration of immune cells and development of further promotion methods

2020 - 2023 血管透過性を抑制する新機序で作用する炎症疾患治療薬の開発

2017 - 2020 Efficient lysis of cancer-associated fibroblasts by next-generation reovirus and development of innovative cancer virotherapy

2015 - 2018 Development of oncolytic virotherapy against both cancer cells and cancer-associated fibroblasts

2014 - 2018 Development of a novel oncolytic virus by regulating the processing of virus-derived non-coding RNA

2014 - 2018 The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseases

2013 - 2016 Elucidation of nuclear import mechanism of argonaute 2 for efficient knockdown of nuclear-localizing non-coding RNA

2013 - 2016 Novel therapeutic strategy for glioma by construction of glioma stem cell specific gene expression system.

2011 - 2015 Development of an efficient gene expression vector utilizing RNA-binding proteins and antisense transcripts

2011 - 2012 Induction of hematopoietic stem/progenitor cells from mouse pluripotent stemceIIsby inhibitionofanadaptor protein, Lnk.

2011 - 2012 Development of a novel nucleic acid drug targeting sense/antisense transcript pairs

2009 - 2011 Identification of a gene that can control expression of endoderm-specific genes

2009 - 2010 新規small RNA分子mirtronの生理的機能の解明

2008 - 2010 Development of an adenovirus vector containing microRNA-regulated gene expression system

2007 - 2008 Role of CLSP in adenovirus infection

2006 - 2007 遺伝子改変間葉系幹細胞を用いたがんに対する新しい細胞治療戦略

2005 - 2007 Research of gene transfer into nonhuman promates using novel types of adenovirus vectors

2005 - 2005 アデノウイルス受容体CARと相同性を有する可溶性新規タンパク質sCARの機能解析

2005 - 2005 新規アデノウイルスベクターによるヒト造血幹細胞への遺伝子導入の最適化

2003 - 2004 癌への特異的標的化を可能とするアデノウイルスベクターシステムの開発

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Papers (197)：

Tomohito Tsukamoto, Haruna Mizuta, Eiko Sakai, Fuminori Sakurai, Hiroyuki Mizuguchi. Evaluation of the correlation between nuclear localization levels and genome editing efficiencies of Cas12a fused with nuclear localization signals. Journal of pharmaceutical sciences. 2024
Fuminori Sakurai, Shunsuke Iizuka, Tomohito Tsukamoto, Aoi Shiota, Kahori Shimizu, Kazuo Ohashi, Hiroyuki Mizuguchi. Transplacental delivery of factor IX Fc-fusion protein ameliorates bleeding phenotype of newborn hemophilia B mice. Journal of Controlled Release. 2024. 374. 415-424
Naomi Shuwari, Chieko Inoue, Ikuho Ishigami, Kentaro Jingushi, Mariko Kamiya, Shigeru Kawakami, Kazutake Tsujikawa, Masashi Tachibana, Hiroyuki Mizuguchi, Fuminori Sakurai. Small extracellular vesicles carrying reovirus, tumor antigens, interferon-β, and damage-associated molecular patterns for efficient tumor treatment. Journal of Controlled Release. 2024. 374. 89-102
Rika Onishi, Sena Ikemoto, Aoi Shiota, Tomohito Tsukamoto, Akira Asayama, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi. Development of a novel adenovirus serotype 35 vector vaccine possessing an RGD peptide in the fiber knob and the E4 orf 4, 6, and 6/7 regions of adenovirus serotype 5. International journal of pharmaceutics. 2024. 124480-124480
Kahori Shimizu, Moe Ono, Takenari Mikamoto, Yuya Urayama, Sena Yoshida, Tomomi Hase, Shotaro Michinaga, Hiroki Nakanishi, Miho Iwasaki, Tomoyuki Terada, et al. Overexpression of lysophospholipid acyltransferase, LPLAT10/LPCAT4/LPEAT2, in the mouse liver increases glucose-stimulated insulin secretion. The FASEB Journal. 2024. 38. 2

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MISC (68)：

櫻井文教, 井上智重子, 種昂なお実, 神宮司健太郎, 神宮司健太郎, 辻川和丈, 辻川和丈, 水口裕之, 水口裕之, 水口裕之, et al. レオウイルス感染がん細胞由来細胞外小胞のがん細胞に対する殺細胞効果の検討. 日本DDS学会学術集会プログラム予稿集. 2021. 37th
Tetsuya Suzuki, Tomohito Tsukamoto, Eiko Sakai, Fuminori Sakurai, Hiroyuki Mizuguchi. Sequence search for cloning and genome editing. Drug Delivery System. 2020. 35. 3. 255-259
Keisaku Wakabayashi, Fuminori Sakurai, Ryosuke Ono, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi. Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A. Anticancer research. 2020. 40. 1. 161-168
Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi. Type I IFN signaling induces Th17 cells capable of promoting gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector. CYTOKINE. 2017. 100. 150-150
Kahori Shimizu, Sakurai Fuminori, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi. Adenovirus Vector-Induced Hepatotoxicity During the Early Phase of Adenoviral Treatment Is Attributed to Inflammatory Cytokine-Induced Leaky Expression of Adenovirus Genes. MOLECULAR THERAPY. 2017. 25. 5. 264-265

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Books (16)：

遺伝子治療薬の臨床開発の現状
情報機構 2024
腫瘍溶解性ウイルスによる抗腫瘍免疫の活性化とがん免疫療法との併用
Drug delivery system 2023
アデノウイルスベクターワクチンの現状と展望
Drug delivery system 2022
ヒト35型アデノウイルスを基本骨格とした腫瘍溶解性アデノウイルスの開発
BIO Clinica 2022
アデノウイルスってどんなものでしたっけ?
日経メディカル(オンライン掲載) 2021

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Lectures and oral presentations (21)：

薬剤師が知っておくべき遺伝子治療薬の特徴
(第34回日本医療薬学会年会 2024)
レオウイルスによるがん微小環境の変化
(第30回日本遺伝子細胞治療学会学術集会 2024)
Antifibrotic effects of oncolytic reovirus
(The 29th Annual Meeting of Japan Society of Gene and Cell Therapy 2023)
Development of a novel oncolytic adenovirus composed of human adenovirus serotype 35
(The 29th Annual Meeting of Japan Society of Gene and Cell Therapy 2023)
Development of a replication-incompetent adenovirus vector and oncolytic adenovirus containing microRNA-mediated post-transcriptional de-targeting system
(2022)

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Education (4)：

1996 - 2001 京都大学大学院薬学研究科薬品動態制御学分野
- 2001 Kyoto University Graduate School of Phamacentical Sciences Drug Delivery System
1992 - 1996 Kyoto University Faculty of Pharmaceutical Sciences
- 1996 Kyoto University Faculty of Pharmaceutical Sciences

Professional career (1)：

Doctor(Pharmacy) (Kyoto University)

Work history (6)：

2024/04 - 現在 Kindai University Department of Pharmacy
2010/04 - 2024/03 Osaka University Graduate School of Pharmaceutical Sciences
2013/04 - 2017/03 大阪大学大学院薬学研究科創薬臨床研究推進分野核酸医薬評価学准教授(兼任)
2014/08 - 2016/07 Ministry of Education,Culture,Sports,Science and Technology
2005/04 - 2010/03 National Institutes of Biomedical Innovation, Health and Nutrition

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Committee career (10)：

2022/08 - 現在日本遺伝子細胞治療学会幹事
2022/04 - 現在文部科学省科学技術・学術政策研究所科学技術予測センター専門調査員
2018/07 - 現在日本遺伝子細胞治療学会評議員
2017/08 - 現在日本DDS学会評議員
2016/07 - 現在日本遺伝子細胞治療学会若手ワーキンググループメンバー

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Awards (8)：

2018/07 - 日本遺伝子細胞治療学会タカラバイオ賞
2017/03 - 大阪大学薬友会賞(研究部門)
2016/07 - 大阪大学総長奨励賞
2015/07 - 大阪大学総長奨励賞
2015/06 - 公益財団法人臨床薬理研究振興財団研究大賞

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Association Membership(s) (11)：

THE JAPANESE SOCIETY FOR VIROLOGY , 日本癌学会 , 日本DDS学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本遺伝子細胞治療学会 , The Japanese Cancer Association , Japan Society of Drug Delivery System , The Japan Society of Gene Therapy , 日本核酸医薬学会 , 日本薬物動態学会 , The Academy of Pharmaceutical Science and Technology, Japna

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