Rchr

J-GLOBAL ID：200901010626080867 Update date: Oct. 16, 2024

Kawao Naoyuki

カワオナオユキ | Kawao Naoyuki

Affiliation and department：
Job title： assistant

Research field (2)： Clinical pharmacy , Physiology

Research keywords (3)：組織修復 , 線溶系因子 , fibrinolytic factors

Research theme for competitive and other funds (31)：

2023 - 2026 慢性腎臓病の骨・筋への影響とPAI-1の役割について
2020 - 2023 運動の筋・骨連関への影響とマイオカインの役割
2019 - 2022 Roles of Wnt/beta-catenin signaling inhibitors in interactions between muscle and bone
2018 - 2021 Elucidation of macrophage function and abnormal of bone marrow stem cells in delayed bone repair in diabetic mice
2016 - 2019 Roles of interaction between liver, muscle and bone in the maintaining bone and glucose/lipid metabolism.

2016 - 2019 脂肪蓄積による筋と骨のネットワーク破綻メカニズムの解明

2015 - 2018 Muscle and bone network system induced by mechanical factors

2015 - 2018 The role of fibrinolytic system during bone repair in diabetes mic

2017 - 筋と骨のネットワークに着目した新規なフレイル予防・治療標的の探索

2013 - 2015 Novel mechanisms of bone regeneration induced by the tissue fibrinolytic system through macrophage regulation

2015 - メカニカルストレスによって誘導される筋と骨のネットワーク機構の骨粗鬆症における役割の解明

2015 - 前庭系による筋と骨の組織間ネットワーク調節に着目した骨粗鬆症の病態機序の解明

2012 - 2014 Roles of tissue-fibrinolytic system in bone/cartilage regeneration

2014 - 骨損傷後の骨・軟骨再生過程における骨/骨髄相互連関による骨髄幹細胞の分化誘導機構およびその調節因子の解明

2014 - 筋と骨のネットワークシステムに着目した閉経後骨粗鬆症の病態機序の解明

2011 - 2013 New synthetic peptide enhances regeneration of tissues

2013 - 進行性骨化性線維異形成症における筋由来破骨細胞分化因子の同定

2011 - 2012 Novel mechanisms of macrophage regulation by u-PA/plasmin system during liver repair

2010 - 2012 Analysis of vascular remodeling by t-PA/t-PAR system

2012 - 進行性骨化性線維異形成症における破骨細胞を介した筋骨化機構

2009 - 2011 Roles of urokinase plasminogen activator receptor expressed in endothelial cells on deterioration of ischemic stroke

2011 - 進行性骨化性線維異形成症の筋骨化機序における線溶系の役割

2008 - 2010 New synthetic peptide enhances plasminogen activation and thrombolysis

2008 - 2009 Novel mechanisms of t-PA-dependent liver regeneration

2007 - 2008 Analysis of regulation by t-PA/t-PAR-mediate protease on regeneration system after tissue damage

2006 - 2007 肝再生過程におけるプラスミン系依存性アポトーシスに関する基礎的研究

2005 - 2006 Analysis of biological function by t-PA receptor gene expression regulation

2006 - 肝再生過程における線溶系因子の役割に関する基礎的研究

2006 - Roles of fibrinolytic factors on liver generation

2003 - 2004 The role of proteolytic system on the liver regeneration : The analysis of gene deficient mice with transplantation of bone morrow

2003 - 2004 Expression of t-PA receptor on the endothelial cell and analysis of its physiological function.

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Papers (109)：

Daichi Matsumura, Naoyuki Kawao, Ayaka Yamada, Katsumi Okumoto, Takashi Ohira, Yuya Mizukami, Koji Goto, Hiroshi Kaji. Tmem119 deficiency delays bone repair in mice. Bone. 2024. 186. 117177-117177
Kiyotaka Okada, Yuto Niwa, Kazusa Fukuhara, Takashi Ohira, Yuya Mizukami, Naoyuki Kawao, Osamu Matsuo, Hiroshi Kaji. Plasminogen activator inhibitor-1 is involved in glucocorticoid-induced decreases in angiogenesis during bone repair in mice. Journal of Bone and Mineral Metabolism. 2024. 42. 3. 282-289
Yuya Mizukami, Naoyuki Kawao, Takashi Ohira, Daiki Hashimoto, Kiyotaka Okada, Osamu Matsuo, Hiroshi Kaji. Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice. Calcified tissue international. 2024. 114. 5. 535-549
Takashi Ohira, Yoko Ino, Naoyuki Kawao, Yuya Mizukami, Kiyotaka Okada, Osamu Matsuo, Hisashi Hirano, Yayoi Kimura, Hiroshi Kaji. Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice. Journal of applied physiology (Bethesda, Md. : 1985). 2024. 136. 3. 643-658
Naoyuki Kawao, Daichi Matsumura, Ayaka Yamada, Katsumi Okumoto, Takashi Ohira, Yuya Mizukami, Daiki Hashimoto, Hiroshi Kaji. Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice. Bone. 2024. 181. 117040-117040

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MISC (75)：

森下貴文, 河尾直之, 橋本晃明, 墳本一郎, 橋本和彦, 奥本勝美, 梶博史, 赤木將男. Subchondral bone at early stage of knee osteoarthritis in aged mice. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
高藤義正, 河尾直之, 奥本勝美, 大平宇志, 水上優哉, 城潤一郎, 田畑泰彦, 梶博史. 筋細胞由来細胞外小胞は糖尿病マウスの骨修復・再生遅延を改善する. 日本再生医療学会総会(Web). 2022. 21st
木下優子, 高藤義正, 奥本勝美, 高田雄斗, 江原裕基, 水上優哉, 河尾直之, 城潤一郎, 田畑泰彦, 梶博史. アイリシンは糖尿病マウスにおける骨修復遅延を改善する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2022. 40th
高藤義正, 河尾直之, 奥本勝美, 大平宇志, 水上優哉, 岡田清孝, 城潤一郎, 田畑泰彦, 梶博史. マウス骨格筋細胞が産生するエクソソームは糖尿病による骨修復遅延を改善する. 日本骨代謝学会学術集会プログラム抄録集(CD-ROM). 2022. 40th
森下貴文, 河尾直之, 橋本晃明, 墳本一郎, 橋本和彦, 梶博史, 赤木將男. 老齢マウス変形性膝関節症モデルを用いた早期OAの軟骨下骨の検討. 近畿大学医学雑誌. 2022. 47. 3-4

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Books (1)：

フレイルのみかた
中外医学社 2018 ISBN:9784498059160

Lectures and oral presentations (84)：

筋骨化シグナルにより誘導される新規因子Tmem176bは筋芽細胞から骨芽細胞への分化を促進する
(第106回生理学談話会 2013)
Tissue-type plasminogen activator is involved in bone repair
(American Society for Bone and Mineral Research 2013 Annual Meeting 2013)
Plasminogen Activator Inhibitor-1 Contributes to the Pathogenesis of Diabetic Osteoporosis in Female Mice
(IBMS-JSBMR 2013 2013)
Plasminogen activator inhibitor-1は糖尿病性骨粗鬆症の病態に関与する
(第56回日本糖尿病学会年次学術集会 2013)
Plasminogen plays an essential role in bone repair
(2nd Joint Meeting of IBMS and JSBMR 2013)

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Education (4)：

- 2004 Kindai University Graduate School of Pharmacy
- 2004 Kinki University Graduate School, Division of Pharmaceutical Sciences
- 1999 Kindai University Faculty of Pharmacy
- 1999 Kinki University Faculty of Pharmaceutical Science Pharmacentical Sciences

Professional career (1)：

薬学博士

Work history (3)：

2015/04 - 現在 Kindai University Faculty of Medicine
2007 - 2015 Kindai University Faculty of Medicine
2004 - 2007 Kindai University Faculty of Medicine

Committee career (3)：

2017/07 - 現在日本血栓止血学会代議員
2011 - 現在日本生理学会評議員
2008 - 現在日本病態生理学会評議員

Awards (2)：

2014 - 22nd International Congress on Fibrinolysis & Proteolysis Young Investigators Awards
2011 - XXIII Congress of the International Society on Thrombosis and Haemostasis Young Investigators Award

Association Membership(s) (10)：

JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , 日本血栓止血学会 , 日本病態生理学会 , 日本生理学会 , 日本薬理学会 , The Japanese Society of Hematology , The Japanese Society on Thrombosis and Hemostasis , Japanese Society of Pathophysiology , The Physiological Society of Japan , The Japanese Pharmacological Society

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