Rchr
J-GLOBAL ID：200901010776835076
Update date: Oct. 23, 2024
Takahashi Nobuhiro
タカハシ ノブヒロ | Takahashi Nobuhiro
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
http://www.dent.tohoku.ac.jp/field/biology/01/index.html
,
http://www.dent.tohoku.ac.jp/english/field/biology/01/index.html
Research field (5)：
Oral medicine
, Healthcare management, medical sociology
, Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Bacteriology
Research keywords (6)：
Anaerobic Chambers for Biochemical and Microbiological Experiments
, Metabolism of Oral Microorganisms and Analysis of Oral Microbial Flora
, Oral Ecosystem and Oral Diseases (Dental Caries and Periodontal Diseases)
, 口腔生態系と全身疾患/健康(発がん、高血圧、健康維持・増進)
, 生体材料の微生物学的劣化
, 低酸素細胞生物学
Research theme for competitive and other funds (58)：
- 2024 - 2028 口腔マイクロバイオームの新・存在意義~全身・口腔健康に寄与する亜硝酸産生の全容~
- 2023 - 2027 早期小児齲蝕(ECC)関連細菌Scardoviaの増殖を促す口腔環境因子の同定
- 2023 - 2026 口腔細菌叢で脳をまもる:抗認知症プラズマローゲンを産生する嫌気性菌の同定と応用
- 2024 - 2025 口腔マイクロバイオームの新機能:「副代謝系」の解明による口腔と全身の健康増進戦略
- 2022 - 2025 呼気オミックスを用いた乳がん口腔支援システムの開発
- 2021 - 2025 口腔マイクロバイオームの新機能:「副代謝系」の解明による口腔と全身の健康増進戦略
- 2021 - 2024 『次代歯周病予防薬』開発のための『選択的予防メカニズム』の解明
- 2020 - 2023 新視点で探る口腔バイオフィルム細菌叢の存在意義~硝酸還元活性と全身・口腔健康~
- 2019 - 2022 脱灰・タンパク質分解包括モデルによる根面う蝕機序解明と予防・治療法の検討
- 2018 - 2022 包括的糖代謝プロファイリングによるScardoviaの齲蝕関連因子の特定
- 2018 - 2021 Do Bacteria Cause Cancer? Elucidation of "cell-microbiome interaction" using metabolism as an indicator
- 2018 - 2021 Development of predictive oral supportive system for perioperative breast cancer patients
- 2017 - 2021 What is a healthy oral microbiome? Proposal of oral health indicators based on metabolic resilience
- 2017 - 2020 How is the nitrite contributing to our general and oral health promotion produced in oral microflora?
- 2016 - 2020 Developing the model using pH/calcium fluorescent imaging for prevention and treatment of dental caries
- 2015 - 2018 Comprehensive analysis in oral microbiome as a promoting factor for esophageal cancer
- 2014 - 2018 The elucidation of the pathogenic activity of periodontal disease-related bacteria by metabolomics approaches; The establishment of new method to monitor their metabolic activity in real-time
- 2014 - 2017 Metabolome analysis of oral biofilm: a possible risk assessment of oral diseases using oral microbiome metabolism
- 2014 - 2017 Development of new evaluation system of mucosal inflammation based upon vascular imaging and preventive method of oral mucositis with oral mucosa mapping system
- 2013 - 2015 Metabolomics of cancer tissue -challenge to the paradoxical energy metabolism of cancer cells
- 2011 - 2015 Investigation of the role of MMP in bone healing with mineral and proteome analyses
- 2010 - 2014 Metabolomic approach to oral biofilm and saliva: possible risk indicator for oral diseases
- 2009 - 2014 Formulation of the rare sugar delivery system for functional food and the safety assessment method
- 2011 - 2013 Parameters of oral environment for perioperative patients of lung cancer based on two dimensional analysis of breath gasses
- 2011 - 2012 Metabolomic approach to metabolic biology of cancer cells
- 2009 - 2010 プラズマローゲン含有口腔内細菌を駆使した認知症治療および予防システムの構築
- 2008 - 2010 Development of accelerated remineralization method based upon the non-invasive assessment of mineral density of tooth
- 2008 - 2010 Contribution of impairment of cough and swallowing reflexes and silent aspiration of oropharyngeal bacteria to the mechanism of postoperative pneumonia
- 2008 - 2010 Development of novel microflora-profiling methods of infected root canals and their application to endodontic therapy
- 2008 - 2010 Two dimensional evaluation by volatile gases for oral condition of diabetes mellitus
- 2008 - 2010 Development of diagnostic system of gingivitis based upon the objective index of peripheral vessel of inflamed tissues
- 2007 - 2009 Metabolome analysis of oral biofilm using CE-TOFMS and its application possibility as an oral health indicator
- 2006 - 2007 生体成分のファウリングを阻止して清浄性を維持する人工材料表面の開発
- 2005 - 2007 Comprehensive and quantitative profiling of microflora of human apical periodontitis
- 2005 - 2007 口腔微生物叢の「揺りかご」:舌苔バイオフィルムの生物学
- 2005 - 2006 Establishment of the diagnostic criteria of root caries and the method for its remineralization based on the optical and physical properties of root surfaces
- 2005 - 2006 Quantification of oral bacterial flora and application to the risk test of oral diseases
- 2004 - 2006 Profiling of oral bacterial flora using DNA chips and its application to the risk evaluation of oral diseases of children.
- 2004 - 2006 Analysis of Molecular and Biological Basis of Systemic Effects Provoked by Periodontal Diseases
- 2003 - 2004 DNAチップを用いた口腔微生物叢の網羅的定量的プロファイリング
- 2002 - 2004 STUDY OF THE PATHOGENESIS AND PHYSICAL NATURE OF DENTAL BIOFILM
- 2002 - 2004 Microbiological study on oral bacterial floral shifts in children
- 2002 - 2003 APPLICATION OF SUGAR ALCOHOLS COCKTAILS TO HUMAN CARIES PREVENTION
- 2001 - 2003 MICROBIOLOGICAL STUDY ON DENTAL CARIES PREVENTION USING SUGAR SUBSTITUTES
- 1999 - 2001 STUDY ON METABOLIC SYSTEMS FOR PEPTIDES AND AMINO ACIDS OF PERIODONTAL PATHOGENS, PORPHYROMONAS AND PREVOTELLA.
- 1999 - 2000 エコシステムとしてのデンタルプラーク-共生と競合のメカニズム-
- 1999 - 2000 黄連・黄柏の抗菌メカニズムの解明
- 1998 - 1999 Inhibitory effects of sugar alcohols on acid production of dental plaque bacteria
- 1997 - 1998 歯周病関連菌の病原性と口腔環境ストレスとの相互作用
- 1996 - 1996 Acid shockによる口腔レンサ球菌の傷害とその回避の生化学的機構
- 1995 - 1995 Acid shock(急激なpH低下)に対する歯垢細菌の応答の生化学的機構
- 1994 - 1994 急激なpH低下(acid shock)に対する歯垢細菌の適応
- 1993 - 1993 口腔疾患関連菌口腔アクチノミセスの代謝活性-INVITROでの基礎的研究
- 1992 - 1992 歯周病関連菌の代謝活性と歯周病巣環境との相互関係-IN VITROでの基礎的研究
- 1991 - 1992 Effects of environmental fluctuations on sugar metabolisms of plaque bacteria.
- 1990 - 1992 Experimental device designed for assay and purification of oxygen-sensitive enzymes and its application.
- 1991 - 1991 歯周疾患関連細菌の糖・アミノ酸・タンパク質代謝活性とその調節酵素に関する研究
- 1986 - 1987 口腔レンサ球菌の嫌気的糖代謝の酸素傷害、及び、その回復機構についての研究
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Papers (216)：
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Nagara Kaku, Miho Kawachi, Anna Wakui, Misato Miyazawa, Manami Imai, Nanase Takahashi, Aya Sato, Takashi Abe, Haruna Sato, Yuki Kato, et al. Molecular microbiological profiling of bottled unsweetened tea beverages: A screening experiment. Journal of Oral Biosciences. 2024. 66. 3. 628-632
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Yuji Yamamoto, Jumpei Washio, Koichi Shimizu, Nobuhiro Takahashi. Effects of nitrate and nitrite on plaque pH decrease and nitrite-producing and -degrading activities of plaque in vitro. Caries research. 2024
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樋口 真由, 安彦 友希, 鷲尾 純平, 高橋 信博. 緑茶カテキンEGCGによる歯周病関連細菌に対する抗菌効果,およびう蝕関連細菌に対する効果との比較. 口腔衛生学会雑誌. 2024. 74. 増刊. 113-113
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Kaito Kanda, Tetsuya Yamada, Yasuko Yanagida, Yuta Kubota, Nobuhiro Matsushita, Gen Mayanagi, Jumpei Washio, Nobuhiro Takahashi. Electrochemical difference between single- and poly-crystalline LaF3 for a compact and low-price fluoride ion sensor. Electroanalysis. 2024
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Sili Han, Jumpei Washio, Yuki Abiko, Linglin Zhang, Nobuhiro Takahashi. Green Tea-Derived Catechins Suppress the Acid Productions of Streptococcus mutans and Enhance the Efficiency of Fluoride. Caries Research. 2023. 57. 3. 255-264
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MISC (71)：
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大関祥久, 山田哲也, 石原昇, 柳田保子, 真柳弦, 真柳弦, 鷲尾純平, 高橋信博. Integration of all-solid-state electrode into the microfluidic channel. 精密工学会大会学術講演会講演論文集. 2022. 2022
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櫻井 泉, 真柳 弦, 山田 聡, 高橋 信博. 根面う蝕モデル 酸による根面内在性タンパク分解酵素の活性化(Root caries model: Acid-induced activation of endogenous proteases embedded in root surfaces). Journal of Oral Biosciences Supplement. 2021. 2021. 316-316
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高橋信博. 口腔保健用機能性食品研究会の挑戦 ~口腔保健から、口腔機能を活かした全身の健康へ~. デンタルビジョン. 2021. 25-28
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櫻井泉, 櫻井泉, 真柳弦, 真柳弦, 山田聡, 高橋信博. Root caries model: Acid-induced activation of endogenous proteases embedded in root surfaces. Journal of Oral Biosciences Supplement (Web). 2021. 2021
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真柳弦, 鷲尾純平, 高橋信博, 大久保信吾, 山田哲也, 石原昇, 柳田保子. Study of all-solid-state ion selective electrodes for multi-ion monitoring in the intraoral. 生体医歯工学共同研究拠点成果報告書. 2021. 2020. 114-114
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Books (23)：
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歯科衛生士辞典
2019
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最新歯科衛生士教本用語集ポケット版
医歯薬出版 2019
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口腔生化学第6版
医歯薬出版 2018
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歯科衛生士国家試験問題研究会(編)「歯科衛生士国家試験予想問題集第2版-新出題基準準拠-」
医歯薬出版 2018
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Interface Oral Health Science 2016: Innovative Research on Biosis-Abiosis Intelligent Interface
2017
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Lectures and oral presentations (124)：
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Metabolic functions of the oral microbiome: How does the oral microbiome function and contribute to our health?
(International Symposium for Interface Oral Health Science 2022 (IOHS) 2022)
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Shoku-gaku: Transdisciplinary Science of Eating, Food, and Nutrition - Promoting lifelong health and wellbeing through right eating and right food -
(International Symposium for Interface Oral Health Science 2022 (IOHS) 2022)
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Unique acid production from sugars and fluoride resistance of a novel caries-associated bacterium Scardovia wiggsiae
(2021FJMU-HKU-TU International Online Symposium on Oral Health Sciences 2021)
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Profiling of microbiota in various drinks of plastic bottle after drinking directly from plastic bottle.
(2021)
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The study on the production of acetaldehyde from ethanol by oral bacteria - Effects of oral environmental factors and ethanol concentration
(2021)
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Committee career (14)：
- 2021/07 - 現在 International Association for Dental Research Regional Board Member
- 2020/01 - 現在 口腔保健用機能性食品研究会 理事長
- 2018/04 - 現在 日本口腔衛生学会 代議員
- 2011/08 - 現在 口腔保健用機能性食品研究会 理事
- 2003/01 - 現在 国際歯科研究学会日本部会(JADR) 理事
- 2002/04 - 現在 歯科基礎医学会 理事
- 2001/04 - 現在 東北大学歯学会 評議員
- 2001/04 - 現在 日本生化学会 評議員
- 2001/04 - 現在 歯科基礎医学会 評議員
- 2020/06 - 2023/05 東北大学歯学会 会長
- 2020/04 - 2023/03 東北大学大学院歯学研究科 研究科長
- 2004/01 - 2020/03 東北大学大学院歯学研究科・歯学部 副研究科長・副学部長
- 2013/01 - 2014/12 国際歯科研究学会日本部会(JADR) 会長
- 1999/04 - 2010/03 日本う蝕研究会議 理事
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Awards (3)：
- 2019/07 - Yngve Ericsson Prize
- 1997/10 - 歯科基礎医学会 学術奨励賞
- 1993/03 - IADR IADR Travel Award
Association Membership(s) (7)：
日本う蝕研究会議(1999/04- 理事)
, 日本生化学会(2001/04- 評議員)
, 国際歯科研究学会日本部会(JADR)(2003/01- 理事)
, 歯科基礎医学会(2002/04- 理事)
, 歯科基礎医学会(2001/04- 評議員)
, 東北大学歯学会(2001/04-2003/03 理事)
, 東北大学歯学会(2001/04- 評議員)
