Asai Daisuke

アサイダイスケ | Asai Daisuke

Affiliation and department：
Job title： Associate Professor
Other affiliations (3)：

St.Marianna University School of Medicine Faculty of Medicine Depertment of Medicine Part-time Lecturer
Sophia University Faculty of Human Sciences Part-time Lecturer
Tokyo-Minami Nursing School Part-time Lecturer

Homepage URL (1)： https://www.shoyaku.ac.jp/

Research field (5)： Pharmaceuticals - health and biochemistry , Pharmaceuticals - analytical and physicochemistry , Molecular biochemistry , Biomaterials , Biomedical engineering

Research keywords (8)： Molecular cellular biology , Biological chemistry , Microbiology , Antimicrobial , Peptide science , Genetic engineering , Drug delivery system (DDS) , Biomaterial science

Research theme for competitive and other funds (16)：

2024 - 2027 Development of a depot formulation that senses the bacterial infection environment and releases antimicrobial peptide drugs
2020 - 2023 Resolving the unresolved antiviral mechanism of sulfated oligosaccharides
2020 - 2023 Development of antimicrobial: Challenge by an artificial multi-functional bio-polymer
2018 - 2021 Ultra-sensitive detection method of membrane antigens and its application to cancer companion diagnosis
2017 - 2020 Development of molecular bases of next generation vaccine: Approach from antigen depot delivery system

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Papers (67)：

Terada, K, Asai, D (Co-first author), Kang, JH, Mori, T, Katayama, Y. Activated tyrosine kinase c-Src-responsive artificial gene carrier: in vitro and in vivo evaluation. ChemistrySelect. 2024. 9. 1. e202303331
Kang, JH, Asai, D, Toita, R. Bisphenol A (BPA) and cardiovascular or cardiometabolic diseases. J. Xenobiot. 2023. 13. 4. 775-810
Shimotori, Y, Ogawa, N, Mamada, S, Miyakoshi, T, Masuda, H, Kitago, S, Shima, T, Asai, D, Kanamoto, T. Synthesis, odour characteristics, and antimicrobial activity of optically active (Z)-7-decen-4-olide and its derivatives. J. Oleo Sci. 2023. 72. 11. 1037-1048
Battulga, T, Dagaerbieke, A, Bai, C, Asai, D, Koshikawa, T, Takemura, H, Miyazaki, K, Yoshida, T. Electrostatic interaction between sulfated polysaccharides and oligopeptides from viral envelope glycoproteins using surface plasmon resonance. Carbohydr. Res. 2023. 528. 108815
Mingxue, B, Asai, D, Koshikawa, T, Takemura, H, Miyazaki, K, Yoshida, T. Synthesis and cytotoxic mechanism of sulfated alkyl oligosaccharides having potent anti-HIV activity. J. Fiber Sci. Technol. 2023. 79. 5. 101-111

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MISC (86)：

Sakagami, H, Fukuchi, K, Asai, D, Kanamoto, T, Koshikawa, T, Takemura, H, Inomata, M, Aimi, H, Kikkawa, Y. Rapid virus inactivation by lignosulfonate. New Food Industry. 2022. 64. 2. 106-110
Sakagami, H, Fukuchi, K, Asai, D, Terakubo, S, Takemura, H, Horiuchi, M, Fujisawa, T, Suguro, M, Toeda, K, Yasui, T, et al. Rapid virus inactivation by alkaline extract of leaves of Sasa sp. New Food Industry. 2020. 62. 11. 785-790
Shi, H, Fukuchi, K, Asai, D, Terakubo, S, Takemura, H, Sakagami, H. Quantification of antitumor, antiviral and neuroprotective activity of twenty Kampo preparations. New Food Industry. 2020. 62. 8. 599-607
淺井大輔, 福田靖, 諸熊一則, 船本大起, 山口優子, 森健, 片山佳樹, 柴山恵吾, 中島秀喜. 抗体産生および抗体特性に及ぼす抗原徐放単独寄与の解明. 日本DDS学会学術集会プログラム予稿集. 2019. 35回. 159-159
Asai, D. BRANSON_Ultrasonic homogenizer (Technical Note, in Japanese). Application Notes_Central Scientific Commerce, Inc. 2018. BRANSON

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Patents (6)：

抗黄色ブドウ球菌剤及び化合物の使用
ヒト免疫不全ウイルス不活性化剤
単純ヘルペス不活性化剤
Rho-キナーゼの新規基質ペプチド
蛍光リガンド及び化学物質のアンドロゲン受容体への結合強度測定方法

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Education (1)：

- 2003 Kyushu University Graduate School of Sciences Department of Chemistry

Professional career (1)：

Ph.D. (Kyushu University)

Work history (8)：

2020/09 - 現在 Showa Pharmaceutical University Laboratory of Microbiology, Faculty of Pharmaceutical Sciences Associate Professor
2017/12 - 2020/08 St.Marianna University School of Medicine Department of Microbiology, Faculty of Medicine Junior Associate Professor
2014/01 - 2018/03 National Institute of Infectious Diseases Department of Bacteriology II Project Researcher (concurrent)
2006/04 - 2017/11 St. Marianna University School of Medicine Department of Microbiology, Faculty of Medicine Assistant Professor
2009/08 - 2011/07 Duke University Department of Biomedical Engineering, Visiting Scholar; under Prof. Ashutosh Chilkoti (concurrent)

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Committee career (1)：

The Japan Sosiety of Drug Delivery System; Councilor

Awards (4)：

2013 - 神奈川県感染症医学会第72回神奈川県感染症医学会例会学術奨励賞次世代医用材料の開発:薬物徐放のための生体吸収性注射ゲル
2009 - 公益財団法人国際科学技術財団 2009年研究助成疾患細胞選択的な遺伝子発現制御技術の創出と治療への応用
2000 - 公益財団法人日本科学協会笹川科学研究助成核受容体コンホメーション法による環境ホルモン作用の評価
1999 - 日本分析化学会九州分析化学ポスター賞内分泌撹乱物質(環境ホルモン)の女性ホルモン受容体結合性の解析

Association Membership(s) (7)：

The Pharmaceutical Society of Japan , American Chemical Society , The Japanese Society for Biomaterials , The Japanese Association for Infectious Diseases , The Japanese Society for Virology , The Japanese Society of Drug Delivery System , The Japanese Biochemical Society

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