Hashiguchi Mitsuko

ハシグチミツコ | Hashiguchi Mitsuko

Affiliation and department：
Job title： Assistant professor

Research field (4)： Medical biochemistry , Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (15)： p25 , p35 , サイクリン指向性蛋白質リン酸化キナーゼ5(CDK5) , 14-3-3 , リン酸化 , タウ蛋白質 , アルツハイマー病 , Neurofilament , Alzheimer's desease(AD) , p35 , p25 , Cyclin-dependent kinase 5 (CDK5) , Phosphorylation , Tau proteins , 14-3-3 proteins

Research theme for competitive and other funds (6)：

2004 - 2010 アルツハイマー病の神経細胞死とタウリン酸化の制御機構および14-3-3たんぱく質による調節機構の研究
末梢神経変性疾患における神経線維のリン酸化調節機構
Establishment of antibodies against modulation of tau phosphorylation.
Mechanism of histamine-induced cell shape and microfilament in endothelial cells.
Mechanisms of neurofilament phosphorylation of peripheral nerve degeneration.

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MISC (27)：

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau. Journal of Biological Chemistry. 2003. 278(2): 1388
M Hashiguchi, T Saito, S Hisanaga, T Hashiguchi. Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser(202)/Thr(205) of human tau. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. 277. 46. 44525-44530
M Hashiguchi, T Saito, S Hisanaga, T Hashiguchi. Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser(202)/Thr(205) of human tau. JOURNAL OF BIOLOGICAL CHEMISTRY. 2002. 277. 46. 44525-44530
14-3-3z is an effector of tau protein phosphorylation. Journal of Biological Chemistry. 2000. 275: 25247-25254
14-3-3z Is an Effector of Tau Protein Phosphorylation. The Journal of Biological Chemistry. 2000. 275(33), 25247-25254

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Works (2)：

老化に伴うニューロフィラメント障害の発生機序と防御法の確立
2000 -
Prevention of aging-induced disruption of neurofilaments
2000 -

Professional career (1)：

Ph. D. (Tokyo Medical University)

Awards (1)：

2003 - 東京医科大学佐々記念賞

Association Membership(s) (12)：

Society for Neuroscience , The American Society for Cell Biology , 日本神経化学会 , 日本癌学会 , 日本生化学会 , 日本生理学会 , The Japanese Cancer Association , The Physiological Society of Japan , The Japanese Society for Neurochemistry , The Japanese Biochemical Society , Society for Neuroscience , The American Society for Cell Biology

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