Rchr
J-GLOBAL ID:200901011185972119
Update date: Jan. 30, 2024
Tokita Yoshihito
トキタ ヨシヒト | Tokita Yoshihito
Affiliation and department:
Job title:
Chief Researcher
Research field (3):
Medical biochemistry
, Neuroscience - general
, Medical biochemistry
Research keywords (6):
抗体医薬
, 先天性無歯症
, 増殖因子
, 遺伝学
, 硬組織発生
, Wnt/β-Catenin signaling
Research theme for competitive and other funds (20):
- 2022 - 2025 希少疾患先天性無歯症患者の欠損歯を再生する新規抗体医薬品の開発
- 2008 - 2021 歯数制御による歯の再生治療薬の開発
- 2016 - 2018 希少疾患先天性無歯症治療薬の開発研究
- 2011 - 2015 The effects of neuroglycan C on neuronal network formation
- 2008 - 2012 Molecular regulation of synaptogenesis
- 2009 - 2011 Neuroglycan C, a chondroitin sulfate proteoglycan, overcomes the abnormal behavior induced by administration of some drugs?
- 2008 - 2011 Roles of neuroglycan C on dendritic spine formation
- 2005 - 2007 Physiological role of neurogrycan C, a protoglycan on a dendritic spine, on neuronal development
- 2004 - 2006 Functional Recovery of Vision with Axonal Regeneration in Crushed Optic Nerve
- 2002 - 2005 Identification of biologically active domains of neuroglycan C that can be applicable to repair of brain injuries
- 2002 - 2004 新奇ニューレグリン、ニューログリカンCのシナプス形成における役割
- 2000 - 2003 Visual Prosthesis -Study of hybrid retinal implant-
- 1998 - 2001 Studies on functions of NGC, a brain-specific proteoglycan, in the brain development by genetic engineering
- 1999 - 2000 半導体素子上に培養した神経細胞の回路形成に関する研究
- 1999 - 2000 発達期の神経組織に特異的な膜蛋白質、ニューログリカンCの神経回路形成における役割
- 1999 - 1999 半導体素子上に培養した神経細胞の回路形成に関する研究
- 1998 - 1998 新奇な神経特異プロテオグリカンNGCのバレル形成における機能の解析
- 1998 - 1998 培養細胞と半導体素子を用いたハイブリット型人工網膜に関する研究
- 1997 - 1998 感覚刺激により中枢で発現制御される新奇幕蛋白質の高次脳機能獲得における役割
- 1997 - 1997 大脳体性感覚野バレル形成における新奇な神経特異的プロテオグリカンの機能
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Papers (86):
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V Ravi, A Murashima-Suginami, H Kiso, Y Tokita, C L Huang, K Bessho, J Takagi, M Sugai, Y Tabata, K Takahashi. Advances in tooth agenesis and tooth regeneration. Regenerative therapy. 2023. 22. 160-168
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Junya Adachi, Yoshihiko Aoki, Hiroto Izumi, Takeshi Nishiyama, Atsuo Nakayama, Masatoshi Sana, Kyoko Morimoto, Atsuo Kaetsu, Takamasa Shirozu, Eriko Osumi, et al. Novel WNT10A variant in a Japanese case of nonsyndromic oligodontia. Human genome variation. 2023. 10. 1. 3-3
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Sayaka Mishima, Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Jun-Ichiro Jo, Ryuji Uozumi, Yukiko Nambu, Boyen Huang, Hidemitsu Harada, et al. Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice. Scientific Reports. 2021. 11. 1. 13674-13674
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Junya Adachi, Yoshihiko Aoki, Tadashi Tatematsu, Hiroki Goto, Atsuo Nakayama, Takeshi Nishiyama, Katsu Takahashi, Masatoshi Sana, Akiko Ota, Junichiro Machida, et al. Novel MSX1 frameshift mutation in a Japanese family with nonsyndromic oligodontia. Human genome variation. 2021. 8. 1. 29-29
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Hiroki Goto, Masashi Kimura, Junichiro Machida, Akiko Ota, Mitsuko Nakashima, Naomi Tsuchida, Junya Adachi, Yoshihiko Aoki, Tadashi Tatematsu, Katsu Takahashi, et al. A novel LRP6 variant in a Japanese family with oligodontia. Human genome variation. 2021. 8. 1. 30-30
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MISC (34):
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Katsu Takahashi, Honoka Kiso, Akiko Murashima-Suginami, Yoshihito Tokita, Manabu Sugai, Yasuhiko Tabata, Kazuhisa Bessho. Development of tooth regenerative medicine strategies by controlling the number of teeth using targeted molecular therapy. INFLAMMATION AND REGENERATION. 2020. 40. 1
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山口 聖士, 町田 純一郎, 釜本 宗史, 木村 将士, 中山 敦雄, 東 雄二郎, 宮地 斉, 時田 義人, 下郷 和雄. ヒト先天性歯牙欠損症の分子遺伝学的解析. 日本口腔科学会雑誌. 2012. 61. 3. 295-295
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山口 聖士, 町田 純一郎, 釜本 宗史, 中山 敦雄, 東 雄二郎, 宮地 斉, 下郷 和雄, 時田 義人. ヒト先天性永久歯欠損症の遺伝学的解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2010. 83回・33回. 4P-1138
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Keiko Nakanishi, Yoshihito Tokita, Sachiko Aono, Fumiko Matsui, Yujiro Higashi, Atsuhiko Oohira. Neuroglycan C, a brain specific chondroitin sulfate proteoglycan, interacts with pleiotrophin. NEUROSCIENCE RESEARCH. 2010. 68. E370-E371
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Keiko Nakanishi, Yoshihito Tokita, Sachiko Aono, Fumiko Matsui, Atsuhiko Oohira. SEARCH FOR THE BINDING PROTEIN OF NEUROGLYCAN C, A BRAIN-SPECIFIC CHONDROITIN SULFATE PROTEOGLYCAN. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009. 59. 294-294
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Patents (2):
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USAG-1を標的分子とした歯数制御による歯の再生治療薬(中和抗体)
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プロテオグリカンのコアタンパク質のポリペプチド、それをコードするDNAおよ びそのプロモーター
Lectures and oral presentations (3):
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部分性無歯症の遺伝学.
(本小児口腔科学会学術大会 教育講演「小児と臨床的遺伝子診断」 2019)
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Variable Penetrance, Expressivity and Pleiotropy of MSX1 Alleles.
(31st Annual David W. Smith Workshop on malformations and morphogenesis. 2010)
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Role of Neuroglycan C, a Brain-specific Proteoglycan, in Neuronal Development.
(The 9th Asia-Pacific Microscopy Conference. 2008)
Education (2):
- 筑波大学第二学群生物学類
- Kyoto University Graduate School of Medicine
Professional career (1):
Association Membership(s) (3):
日本分子生物学会
, 日本生化学会
, 日本神経科学学会
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