Research theme for competitive and other funds (17)：
2018 - 2021 Inheritance of environmental impacts on DNA methylation through sperm to the next generation embryos
2017 - 2020 Identification of sperm small RNAs involved in multigenerational health effects of environmental chemicals
2016 - 2019 Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
2015 - 2018 The involvement of cellular senescence in hepatic tumors that increase through multiple generations by gestational arsenite exposure
2015 - 2017 Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatin tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant mice
2014 - 2017 Studies on epimutations that are involved in multigenerational effects of environmental chemicals in mice
2013 - 2016 Assessment of current lung cancer and related health risk by past-exposure of particulates suspended in air
2011 - 2014 Involvement of oxidative stress in the epigenetic changes induced by environmental chemicals
2007 - 2008 Studies on the effect of arsenic on the transcription factors in immune cells
1994 - 1995 Studies on the activation-associated ganglioside in rat T cell
1992 - 1992 Tリンパ球の成熟における細胞膜ガングリオシド構造の変化に関する研究
1991 - 1991 ラットリンパ球特異的ガングリオシドの研究
1987 - 1987 taurolipidによるシアリダーゼ阻害作用
環境化学物質のエピジェネティクス作用
ダイオキシンの免疫毒性
Epigenetics of environmental chemicals
Immunotoxicity of TCDD
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Papers (126)：
Takehiro Suzuki, Kazuyuki Okamura, Keiko Nohara. Characteristics of Global Methylation Changes in F1 Mice Sperm DNA Induced by Gestational Arsenic Exposure Are Re-Established in F2 Somatic Cells but Not in F2 Germ Cells. Genes to cells : devoted to molecular & cellular mechanisms. 2025. 30. 3. e70022
Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Tomoko Kawai, Kazuhiko Nakabayashi. Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos. Epigenetics & chromatin. 2025. 18. 1. 4-4
Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara. Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7. Environmental health and preventive medicine. 2024. 29. 74-74
Chaw Kyi-Tha-Thu, Soe-Minn Htway, Takehiro Suzuki, Keiko Nohara, Tin-Tin Win-Shwe. Gestational arsenic exposure induces anxiety-like behaviors in F1 female mice by dysregulation of neurological and immunological markers. Environmental Health and Preventive Medicine. 2023. 28. 43-43
Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara. Inorganic arsenic exposure-induced premature senescence and senescence-associated secretory phenotype (SASP) in human hepatic stellate cells. Toxicology and applied pharmacology. 2022. 454. 116231-116231
Overcoming environmental risks to achieve sustainable development goals : lessons from the Japanese experience
Springer Nature Singapore 2022 ISBN:9789811662485
Arsenic contamination in Asia : biological effects and preventive measures
Springer 2019 ISBN:9789811325649
1990/07 - 2001/12 National Institute for Environmental Studies
1993/10 - 1994/10 Georgetown University Medical Center Department of Biochemistry and Molecular Biology Grantee of the NCI-JFCR Research Training Program
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Committee career (13)：
2022 - 現在 環境省、臭素系ダイオキシン類実態解明等に関する調査業務の検討会 委員
2021 - 現在 環境省、環境リスク評価委員会 免疫毒性評価ワーキンググループ 委員
2017/10 - 現在 Science Council of Japan member
2012/08 - 現在 The Japan Society for DOHaD councilor
- 現在 日本免疫毒性学会 理事、評議員
2013/10 - 2024/09 食品安全委員会 専門委員
- 2023/03 日本衛生学会 評議員、編集委員、代議員
2022 - WHO Working Group (WG) on TEF values for dioxin and dioxin-like PCBs Expert
2016 - 2016 Review Committee Meeting, National Health Research Institutes, Taiwan International Expert
2010 - 2011 科学技術政策研究所 客員研究官
2007 - 2008 Society of Toxicology (USA) Member of the Program Committee of Immunotoxicology Specialty Section
2001 - 2005 環境省 ダイオキシン類のTDIの評価に関するワーキンググループ 委員
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Awards (3)：
2021/09 - 日本免疫毒性学会 学会賞 ダイオキシン類の免疫毒性作用とそのメカニズム
1993 - NCI-JFCR NCI-JFCR Research Training Program
1987 - お茶の水女子大学 お茶の水女子大学人間文化研究科奨学金
Association Membership(s) (11)：
International Society of DOHaD
, 日本エピジェネティクス研究会
, 日本癌学会
, 日本毒性学会
, 日本DOHaD学会
, THE JAPANESE SOCIETY FOR HYGIENE
, 日本分子生物学会
, 日本免疫毒性学会
, Society of Toxicology (USA)
, 日本免疫学会
, The Japanese Biochemical Society
