Research keywords (10)：
RNA virus
, Emerging and re-emerging infectious diseases
, Mutation
, Structure
, Function
, replication
, pathogenesis
, persistent infection
, epidemics
, Evolution
Research theme for competitive and other funds (12)：
2016 - 2019 HIV Gag 蛋白質の機能と進化能の構造生物学研究に基づく次世代の創薬シーズ創成
2013 - 2016 HIV Gag 蛋白質と関連因子の治療標的構造の解明に向けた統合的研究
2013 - 2014 RNA ウイルスの進化的脆弱性に関する研究
2010 - 2013 HIV の構造、増殖、変異に関する研 究
2007 - 2010 薬剤耐性 HIV の発生機序とその制御 方法に関する研究
2004 - 2007 HIV の増殖・変異の制御に関する研 究
2001 - 2004 HIV 及びその関連ウイルスの増殖機構及 び増殖制御に関する研究
2001 - 2003 STUDY ON MOLECULAR EPIDEMIOLOGY OF HIV AND HOST FACTOR INFLUENCING DISEASE PROGRESSION IN ASIA
1997 - 1997 「HIV-1サブタイプEの遺伝学的ウイルス学的特性に関する研究」
1995 - 1997 タイ型HIV-1の分子疫学とそれを標的とする遺伝子免疫技術の開発
1995 - 1997 タイ型HIV-1の分子疫学とそれを標的とする遺伝子免疫技術の開発
Structure, replication, and evolution of RNA viruses
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Papers (172)：
Masaru Yokoyama, Yen Hai Doan, Kazushi Motomura, Hironori Sato, Tomoichiro Oka. Strong evolutionary constraints against amino acid changes in the P2 subdomain of sapovirus GI.1 capsid protein VP1. Biochemical and biophysical research communications. 2024. 710. 149878-149878
Yoshihiro Samune, Akatsuki Saito, Tadahiro Sasaki, Ritsuko Koketsu, Narinee Srimark, Juthamas Phadungsombat, Masaru Yokoyama, Osamu Kotani, Hironori Sato, Atsushi Yamanaka, et al. Genetic regions affecting the replication and pathogenicity of dengue virus type 2. PLOS Neglected Tropical Diseases. 2024. 18. 1. e0011885-e0011885
Mai Izumida, Osamu Kotani, Hideki Hayashi, Chris Smith, Tsutomu Fukuda, Koushirou Suga, Masatomo Iwao, Fumito Ishibashi, Hironori Sato, Yoshinao Kubo. Unique Mode of Antiviral Action of a Marine Alkaloid against Ebola Virus and SARS-CoV-2. Viruses. 2022. 14. 4. 816-816
Christopher Sumner, Osamu Kotani, Shuohui Liu, Karin Musier-Forsyth, Hironori Sato, Akira Ono. Molecular Determinants in tRNA D-arm Required for Inhibition of HIV-1 Gag Membrane Binding. Journal of Molecular Biology. 2022. 434. 2. 167390-167390
Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, et al. Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses. Viruses. 2021. 13. 9. 1733-1733
1982 - 1987 The University of Tokyo Faculty of Science Graduate School of Arts and Sciences
1980 - 1982 The University of Tokyo Faculty of Arts and Sciences Division of Basic Science
1978 - 1980 The University of Tokyo
Professional career (1)：
Doctor of Science (The University of Tokyo)
Work history (8)：
2019/04 - 現在 National Institute of Infectious Diseases Pathogen Genomics Center Senior Scientist
2005/10 - 2019/03 National Institute of Infectious Diseases Pathogen Genomics Center Laboratory Chief
2001/08 - 2005/09 National Institute of Infectious Diseases Division of Molecular Genetics Principal Investigator
1997/04 - 2001/07 National Institute of Infectious Diseases AIDS Research Center, Senior Scientist
1993/04 - 1997/03 National Institute of Infectious Diseases AIDS Research Center, Junior Scientist
1991/04 - 1993/03 National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Visiting Associate
1989/06 - 1991/03 National Institutes of Health (NIH) National Institute of Allergy and Infectious Diseases (NIAID) Merck Postdoctoral Research Fellow
1987/04 - 1989/05 国立予防衛生研究所 ヒューマンサイエンス振興財団流動研究員
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Committee career (14)：
2022/04 - 現在 Japan Agency for Medical Research and Development Program Officer
2020/04 - 現在 Japan Agency for Medical Research and Development Program Officer
2020/04 - 現在 Viruses Editorial Board Members
2020 - 現在 The Japanese Society for Virology director
2019 - 現在 Japan Agency for Medical Research and Development Program Officer (International Collaborative Research Program: Strategic International Collaborative Research Program (SICORP))
2018 - 現在 Ministry of Agriculture, Forestry and Fisheries Specialized research committee, Food Safety Commission of Japan
2018 - 現在 Ministry of Health, Labor and Welfare Pharmaceutical Affairs and Food Sanitation Council
2016 - 現在 The Japanese Society for AIDS Research councilor
2011 - 現在 Frontiers in Microbiology Associate Editor (Virology)
2004 - 現在 The Japanese Society for Virology councilor
2007 - 2008 The Japanese Society for AIDS Research director
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Association Membership(s) (4)：
Japanese Society of Tropical Medicine
, The Molecular Biology Society of Japan
, The Japanese Society for Virology
, The Japanese Society for AIDS Research
