Rchr
J-GLOBAL ID:200901011579460040   Update date: Feb. 14, 2024

Mizoguchi Hirokazu

ミゾグチ ヒロカズ | Mizoguchi Hirokazu
Affiliation and department:
Job title: 教授
Research field  (3): Pharmacology ,  Pharmaceuticals - health and biochemistry ,  Neuroscience - general
Research keywords  (6): 細胞内情報伝達 ,  鎮痛 ,  オピオイド受容体 ,  Signal transduction ,  Antinociception ,  Opioid receptor
Research theme for competitive and other funds  (14):
  • 2021 - 2024 難治性掻痒に対する副作用の無い特異的治療薬の開発
  • 2015 - 2018 Methadone-used new therapy for morphine-resistant intractable pain
  • 2014 - 2017 Development of selective agonists for the morphine-insensitive opioid mu receptor splice variants
  • 2013 - 2016 Investigation for the histamine-related mechanism of neuropathic pain and development of its therapy
  • 2012 - 2015 The mechanism for multiple sclerosis-related pain and its new therapy
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Papers (71):
  • Damiana Scuteri, Laura Rombolà, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Luigi Antonio Morrone, Paolo Tonin, et al. Translational Value of the Transdermal Administration of Bergamot Essential Oil and of Its Fractions. Pharmaceutics. 2022. 14. 5
  • Damiana Scuteri, Laura Rombolà, Michele Crudo, Chizuko Watanabe, Hirokazu Mizoguchi, Shinobu Sakurada, Kengo Hamamura, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti, et al. Preclinical Characterization of Antinociceptive Effect of Bergamot Essential Oil and of Its Fractions for Rational Translation in Complementary Therapy. Pharmaceutics. 2022. 14. 2
  • Yoshizumi Masaru, Watanabe Chizuko, Mizoguchi Hirokazu. TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 3-B-P-204
  • Masaru Yoshizumi, Naoya Tazawa, Chizuko Watanabe, Hirokazu Mizoguchi. TRPV4 activation prevents lipopolysaccharide-induced painful bladder hypersensitivity in rats by regulating immune pathways. Frontiers in immunology. 2022. 13. 1080302-1080302
  • Masaru Yoshizumi, Akihiko Yonezawa, Yukio Kimura, Chizuko Watanabe, Shinobu Sakurada, Hirokazu Mizoguchi. Central Mechanisms of Apomorphine and m-Chlorophenylpiperazine on Synergistic Action for Ejaculation in Rats. The journal of sexual medicine. 2021. 18. 2. 231-239
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MISC (182):
  • 渡辺千寿子, 善積克, 櫻田忍, 溝口広一. Mirror image pain発現機構におけるアストロサイトの関与. 日本薬理学雑誌. 2022. 157. Supplement
  • 善積克, 渡辺千寿子, 溝口広一. 間質性膀胱炎/膀胱痛症候群におけるガバペンチノイドの治療機序. 日本薬理学雑誌. 2022. 157. Supplement
  • 渡辺千寿子, 込山麻美, 善積克, 櫻田忍, 溝口広一. 炎症性疼痛制御におけるmethadoneの特異的作用. 日本緩和医療薬学会年会プログラム・要旨集. 2019. 13th
  • 善積克, 角貴祐, 渡辺千寿子, 櫻田忍, 溝口広一. 神経障害性疼痛に対するmethadoneの脊髄鎮痛作用. 日本緩和医療薬学会年会プログラム・要旨集. 2019. 13th
  • 溝口広一, 青木祐太, 渡辺千寿子, 善積克, 櫻田忍. 炎症性疼痛下におけるmorphineの鎮痛作用減弱機構. 日本緩和医療薬学会年会プログラム・要旨集. 2019. 13th
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Works (4):
  • 新規εオピオイド受容体の作動薬の開発
    1997 - 2002
  • The development of new ε-opioid receptor agonist
    1997 - 2002
  • 内因性オピオイドペプチドを介した疼痛制御機構の解明
    1994 - 2002
  • Investigation of the endogenous opioid peptides-mediated pain control system
    1994 - 2002
Education (4):
  • - 1994 Hoshi University Hoshi University
  • - 1994 Hoshi University Graduate School, Division of Pharmaceutical Sciences Pharmacy
  • - 1988 Hoshi University Hoshi University Hoshi University
  • - 1988 Hoshi University Faculty of Pharmaceutical Science Pharmacy
Professional career (2):
  • Doctor(Pharmacy) (Hoshi University)
  • Master(Pharmacy) (Hoshi University)
Work history (16):
  • 2002 - 2003 東北薬科大学機能形態学教室 助手
  • 2002 - 2003 Instructor, Department of Physiology and
  • 2003 - - 東北薬科大学機能形態学教室 講師
  • 2003 - - Assistant Professor, Department of Physiology
  • 2000 - 2002 米国ウィスコンシン医科大学麻酔科 講師
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Committee career (2):
  • 2002 - 2006 日本薬理学会 学術評議員
  • 2002 - 2006 The Japanese Pharmacological Society Board member
Association Membership(s) (10):
鎮痛剤・オピオイドペプチド研究会 ,  日本神経精神薬理学会 ,  日本薬学会 ,  アメリカ神経科学会 ,  日本薬理学会 ,  Japanese Narcotic Research Conference ,  The Japanese Society of Neuropsychopharmacology ,  The Pharmaceutical Society of Japan ,  Sociaty for Neuroscience ,  The Japanese Pharmacological Society
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