Rchr
J-GLOBAL ID:200901011825044876
Update date: Oct. 24, 2024
Abe Ikuro
アベ イクロウ | Abe Ikuro
Affiliation and department:
Homepage URL (2):
https://tennen.f.u-tokyo.ac.jp/professor.html
,
https://tennen.f.u-tokyo.ac.jp/professor-e.html
Research field (3):
Environmental and pharmaceutical development resources
, Bioorganic chemistry
, Molecular biochemistry
Research keywords (6):
天然物化学
, 生物有機化学
, 生合成工学
, 合成生物学
, 酵素工学
, ケミカルバイオロジー
Research theme for competitive and other funds (42):
- 2021 - 2024 腸内細菌による薬物代謝活性化の分子基盤の解明
- 2020 - 2024 新たな創薬資源の採集調査と新奇天然物生合成マシナリーの探索と解明
- 2020 - 2023 複雑骨格天然物生合成酵素の精密構造機能解析に基づく合成生物学と創薬
- 2021 - 2022 生合成リデザイン・研究総括班
- 2019 - 2022 霊芝メロテルペノイド薬用有効成分の生合成研究
- 2018 - 2021 免疫抑制剤ラパマイシンの合成生物学に関する研究
- 2016 - 2021 Redesigning Biosynthetic Machineries (Project Team)
- 2016 - 2021 Next Generation Natural Product Chemistry by Rational Reconstruction of Artificial Biosynthesis Machinery
- 2016 - 2021 Redesigning Biosynthetic Machineries (International Activity Support Team)
- 2016 - 2021 Creation of Complex Functional Molecules by Rational Redesign of Biosynthetic Machineries
- 2018 - 2020 アルキルプロリン由来天然物の生合成に関わる酵素の構造生物学研究
- 2018 - 2020 Production and function of secondary metabolites encoded by the human symbiotic bacterial genome
- 2016 - 2019 霊芝メロテルペノイド薬用有効成分の生合成研究
- 2016 - 2018 Reprogramming of the polyketide synthase/peptide synthetase from Streptomyces
- 2015 - 2018 Biosynthetic studies on complex natural products
- 2014 - 2018 Collection and survey of biosynthetic genes of spore-derived biologically active substances and clarification of biosynthetic machinery
- 2015 - 2017 複雑骨格天然物の生合成に関わる酵素の構造機能解析
- 2014 - 2016 ブルガリア特産薬用植物の生理活性成分に関する研究
- 2014 - 2016 Engineering Modular-type Polyketide Synthases
- 2010 - 2016 Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites
- 2013 - 2015 タンパク質脱リン酸化酵素選択的阻害剤としてのカリクリンA誘導体ライブラリーの構築
- 2011 - 2015 Enzyme engineering for natural product biosynthesis
- 2010 - 2015 Studies on biosynthetic assembly line of meroterpenoids
- 2012 - 2014 Biosynthetic Studies on Okadaic Acid
- 2012 - 2013 メタゲノム法を用いた生物活性物質、遺伝子、酵素の探索
- 2012 - 2013 微細藻由来トリテルペン合成酵素の構造機能解析
- 2008 - 2010 Diversification of Molecular Structures by Merger of Biosynthetic Pathways
- 2008 - 2010 Structure-based Engineering of Enzymes Involved in the Biosynthesis of Secondary Metabolites
- 2007 - 2008 生合成酵素を用いた非天然型新規化合物の構築ライブラリーの構築
- 2007 - 2008 植物ポリケタイド生合成工学による分子多様性の創出
- 2006 - 2007 Biosynthesis of Plant Polyketides; Structure Function Analyses of Novel Type III Polyketide Syntheses
- 2005 - 2006 Combinatorial Biosynthesis of Plant Polyketides and Polyprenoids
- 2005 - 2005 スクアレン環化酵素活性中心探索プローブと超天然型ステロイドの創出
- 2004 - 2005 Structure Function Analysis of Plant Type III Polyketide Synthases
- 2003 - 2004 Formation of unnatural novel polyketides and isoprenoids from alternate and/or nonphysiological substrate by the engineered plant enzymes
- 2002 - 2003 Construction of A Chemical Library of Unnatural Natural Products by Using Biosynthetic Enzymes
- 2001 - 2002 スクアレンエポキシダーゼの構造機能解析
- 2001 - 2002 Functional diversity of chalcone synthase
- 2000 - 2001 Structure-Function Analysis of A Novel Oxidosqualene Cyclase Involved in the Biosynthesis Antibiotics
- 2000 - 2000 コレステロール生合成の鍵酵素となるフラビン酸素添加酵素に関する生物有機化学的研究
- 二次代謝酵素の機能制御と生合成工学
- 天然物化学、生物有機化学
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Papers (301):
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Lu Zhou, Takayoshi Awakawa, Richiro Ushimaru, Masahiro Kanaida, Ikuro Abe. Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in l-Isovaline Biosynthesis. Organic Letters. 2024. 26. 3. 724-727
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Richiro Ushimaru, Lide Cha, Shotaro Shimo, Xiaojun Li, Jared C Paris, Takahiro Mori, Kazunori Miyamoto, Lindsay Coffer, Masanobu Uchiyama, Yisong Guo, et al. Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes. Journal of the American Chemical Society. 2023. 145. 44. 24210-24217
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Richiro Ushimaru, Yiling Ding, Takahiro Mori, Kazunori Miyamoto, Masanobu Uchiyama, Ikuro Abe. Structural and Mechanistic Insights into the C-C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase. Journal of the American Chemical Society. 2023. 145. 40. 21966-21973
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Takeshi Tsunoda, Hatem A. Abuelizz, Arash Samadi, Chin Piow Wong, Takayoshi Awakawa, Corey J. Brumsted, Ikuro Abe, Taifo Mahmud. Catalytic Mechanism of Nonglycosidic C-N Bond Formation by the Pseudoglycosyltransferase Enzyme VldE. ACS Catalysis. 2023. 13369-13382
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Takahiro Mori, Xin Sun, Stanislav Kadlcik, Jiri Janata, Ikuro Abe. Structure-Function Analysis of the S-Glycosylation Reaction in the Biosynthesis of Lincosamide Antibiotics. Angewandte Chemie (International ed. in English). 2023. 62. 29. e202304989
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MISC (48):
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ZHOU Lu, 淡川孝義, 淡川孝義, 阿部郁朗. Biosynthesis of dihydroxyardeemin by heterologous expression. 日本薬学会年会要旨集(Web). 2023. 143rd
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Nwet Nwet Win, Takeshi Kodama, Zin Paing Htoo, Saw Yu Yu Hnin, Hla Ngwe, Ikuro Abe, Hiroyuki Morita. Shanpanootols g and h, diterpenoids from the rhizomes of kaempferia pulchra collected in myanmar and their vpr inhibitory activities. Chemical and Pharmaceutical Bulletin. 2021. 69. 9. 913-917
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Hui Tao, Ikuro Abe. Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids. Current Opinion in Biotechnology. 2021. 69. 52-59
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Lena Barra, Ikuro Abe. Chemistry of fungal meroterpenoid cyclases. Natural Product Reports. 2021. 38. 3. 566-585
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Xinyang Li, Jian-Ming Lv, Dan Hu, Ikuro Abe. Biosynthesis of alkyne-containing natural products. RSC Chemical Biology. 2021. 2. 1. 166-180
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Education (3):
- 1986 - 1989 東京大学 大学院 薬学系研究科 博士課程
- 1984 - 1986 東京大学 大学院 薬学系研究科 修士課程
- 1979 - 1984 東京大学 薬学部 薬学科
Professional career (1):
Work history (5):
- 2009 - 現在 東京大学 大学院 薬学系研究科 教授
- 1998 - 2009 静岡県立大学 薬学部
- 1996 - 1998 ユタ大学 医薬化学科
- 1991 - 1995 State University of New York at Stony Brook Research Assistant Professor
- 1989 - 1991 フランス国立天然物化学研究所、ミュールーズ国立高等化学院
Awards (10):
- 2023 - 日本放線菌学会 大村賞(学会賞)
- 2019 - 日本薬学会 学会賞
- 2019 - 科学技術分野の文部科学大臣表彰 科学技術賞(研究部門)
- 2017 - 日本生薬学会 学会賞
- 2017 - 住木・梅澤記念賞
- 2015 - FAOBMB Osamu Hayaishi Lecture Award
- 2013 - Fellow of The Royal Society of Chemistry
- 2008 - 日本薬学会 学術振興賞
- 2007 - 日本生薬学会 学術貢献賞
- 2003 - 日本生薬学会 学術奨励賞
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