Research theme for competitive and other funds (47)：
2020 - 2023 Clinical epidemiology of MGRS-associated kidney diseases
2019 - 2022 IgA腎症の糸球体沈着性糖鎖異常IgA1の同定と迅速診断法の臨床応用
2019 - 2022 糖尿病性腎症の代謝変容の解明とその改善を基軸とした発症・進展予防
2019 - 2022 Development of leukocytes and endothelial cell-derived biomarkers for glomerular endothelial injuries
2017 - 2020 International Study for Development and Clinical Aplication of Lupus Biomarkers Reflecting Renal Inflammation
2016 - 2019 Research on diagnosis, treatment and epidemiology of membrane nephropathy in the Asia-Pacific region
2016 - 2019 Development of novel antihypertensive therapy with tissue protection in renal and cardiovascular diseases through elucidation of MK-EETs blood pressure regulation mechanism
2016 - 2019 Proteomic analysis of IgA immune complxes in IgA nephropathy
2016 - 2019 Establishment of renal protection strategy by icosapentaic acid (EPA) and elucidation of mechanism of action
2014 - 2019 Development of blood Abeta removal system toward a preliminary clinical study
2016 - 2018 Functional analysis of (pro)renin receptor in the genesis of pancreatic cancer
2015 - 2018 Development of biomarker for IgAN: Development of biomarker for IgAN: An international collaboration study
2015 - 2018 Omics analysis applicable to preemptive medicine of chronic kidney disease -focusing on comprehensive analysis of phosphorylated proteins-
2015 - 2018 Evaluation of renal plasma flow and glomerular filtration rate in the patients with sepsis
2015 - 2018 Cross-talk between the kidneys and the lungs
2014 - 2017 慢性腎臓病患者におけるテロメア消耗と環境因子の国際比較
2014 - 2017 Involvement of acidification of glomerular cells by AGE-cholesterol-aggregated proteins in development of diabetic nephropathy
2013 - 2016 Research on membranous nephropathy in Asia Pacific region
2013 - 2016 Investigation of chronic inflammation and strategy of new therapy using regulatory T cell in chronic kidney disease
2013 - 2016 Development of novel diagnosis method for renal desease using metabolome analysis
2012 - 2015 Development of next-generation diagnostic chip and its application to clinical diagnosis
2012 - 2015 Development of metabolomic biomarkers for early detection of acute kidney injury in kidney transplantation.
2011 - 2014 International comparison of genomic variations for prognostic factors in chronic kidney disease
2011 - 2012 Elucidation of the lung and kidney cross-talk in acute kidney injury(AKI) and evaluation of urinary midkine as a diagnostic marker of AKI.
2010 - 2012 Establishment of immune complex-mediated disease models by human patient sera
2010 - 2012 Establishment of a new disease concept "the kidney and lung correlation through RAS in a renal damage"
2010 - 2012 Development of a new immunosuppressive therapy using adipose derived mesenchymal stem cell
2009 - 2011 Development of novel biomarkers for acute kidney disease by metabolome analysis
2009 - 2011 Development of the therapy for the renal diseases using the cells derived from adipose tissue
2009 - 2011 第3のガスメッセンジャー硫化水素の誘導性産生機序とその役割の解明
2008 - 2010 Creation and evaluation of the novel concept of the therapeutic blood purification system for Alzheimer's Disease by the removal of blood amyloid beta
2007 - 2008 Role of Basigin-VEGF/NO signal in the diabetic nephropathy
2007 - 2008 A new paradigm for the kidney regenerative medicine using adipose derived cells
2006 - 2007 Clinical implication of urinary midkine as a sensitive biomarker of acute kidney injury
2005 - 2006 The establishment of new animal models for diabetic nephropathy (DN) and the development of Midkine-targeted therapy against DN.
2003 - 2004 Basic research for the development of new therapeutic measures against progressive tubuloinetsrtitial injury.
2003 - 2004 Therapeutic Potential of Anti-Midkine Therapy in Progressive Renal Diseases
2001 - 2002 Research on The Role of Proximal Tubular Cells in The Development of Tubulointerstitinal Injury.
2001 - 2002 Role of Midkine in Glomerular and Tubulointerstitial Injuries
1998 - 1999 The Role of Selections in The Formation of Glomerular Thrombi
1997 - 1998 Research on The Mechanisms of Tubulointerstitial Injury by Proteinuria.
1988 - 1989 Immunopathologic Study on The Pathogenesis of Glomerulonephritis
腎症におけるヘパリン結合型成長因子;ミッドカインの関与
腎症における接着分子(特にセレクチン)の関与
Role of Midkine,a Retinoic Acid-Inducible Heparin-Binding Growth Factor in Renal Diseases
Role of Adhesion Molecules(esp.selectins) in Renal Diseases
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Papers (274)：
Daijo Inaguma, Yoshitaka Tatematsu, Naoki Okamoto, Soshiro Ogata, Hideki Kawai, Eiichi Watanabe, Yukio Yuzawa, Midori Hasegawa, Naotake Tsuboi. Multicentre, open-label, randomised, controlled trial to compare early intervention with calcimimetics and conventional therapy in preventing coronary artery calcification in patients with secondary hyperparathyroidism (UPCOMING): a study protocol. BMJ open. 2024. 14. 1. e076962
Hiroya Menjo, Midori Hasegawa, Hidetsugu Fujigaki, Takuma Ishihara, Shun Minatoguchi, Shigehisa Koide, Hiroki Hayashi, Midori Saito, Kazuo Takahashi, Hiroyasu Ito, et al. Comparison of the Serial Humoral Immune Response According to the Immunosuppressive Treatment after SARS-CoV-2 mRNA Vaccination. Internal medicine (Tokyo, Japan). 2023
Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Masayuki Yamanouchi, Junichi Hoshino, Shinji Kitajima, Akinori Hara, Yasunori Iwata, Norihiko Sakai, Yukio Yuzawa, et al. Polar vasculosis is associated with better kidney outcome in type 2 diabetes with biopsy-proven diabetic kidney disease: A multicenter cohort study. Journal of diabetes investigation. 2023
Shoya Oyama, Hiroshi Takahashi, Hiroki Hayashi, Shigehisa Koide, Shigeru Nakai, Kazuo Takahashi, Daijo Inaguma, Midori Hasegawa, Junichi Ishii, Yukio Yuzawa, et al. Combination of brain natriuretic peptide and urinary albumin as a predictor of cardiovascular-renal events in outpatients with chronic kidney disease. Fujita medical journal. 2023. 9. 2. 105-112
Eri Koshi-Ito, Daijo Inaguma, Haruka Ishii, Yukio Yuzawa, Daijiro Kabata, Ayumi Shintani, Masaaki Inaba, Masanori Emoto, Katsuhito Mori, Tomoaki Morioka, et al. Associations of time-dependent changes in phosphorus levels with cardiovascular diseases in patients undergoing hemodialysis: results from the Japan Dialysis Active Vitamin D (J-DAVID) randomized clinical trial. Clinical kidney journal. 2022. 15. 12. 2281-2291
Renfrow, Jan Novak, Synthesis of Galactose-deficient IgA1 O-glycans by GalNAc-transferases: Implications for The Pathogenesis of IgA Nephropathy
(Ykohama, Japan 2013)
2022/05 - 現在 Association of Japan Medical Colleges (AJMC) Adviser
2015/04 - 現在 公益財団法人 愛知腎臓財団 慢性腎臓病(CKD)対策協議会 委員長
2013/01 - 現在 The Japanese Society for Dialysis Therapy The Committee of International Communication for Academic Research(CICAR)
1997 - 現在 一般社団法人日本腎臓学会 評議員
2020/05 - 2022/05 Association of Japan Medical Colleges (AJMC) Chairman
2016/06 - 2020/06 Japanese Society of Nephrology Board Member
2018/06 - 2020/05 愛知県医師会 理事
2012/04 - 2014/03 Grant-in-Aid for Intractable Renal Diseases Research, Research on rare and intractable diseases, Health and Labour Sciences Research Grants from the Ministry of Health, Labour and Welfare of Japan Committee chairman, Clinical Guidelines for IgA Nephropathy 2014 Advisory Committee
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Association Membership(s) (6)：
Japanese Society of Internal Medicine
, Japanese Society for Dialysis Therapy
, Japanese Society of Nephrology
, European Renal Association-European Dialysis and Transplant Association (ERA/EDTA)
, International Society of Nephrology
, American Society of Nephrology
