Rchr
J-GLOBAL ID：200901012294777853   Update date: Mar. 02, 2023

Koinuma Daizo

Koinuma Daizo
Affiliation and department：
The University of Tokyo

About The University of Tokyo


Homepage URL  (1)： http://beta-lab.umin.ac.jp/
Research field  (5)： Respiratory medicine ,  Cell biology ,  Molecular biology ,  Genetics ,  Biological, health, and medical informatics
Research keywords  (17)： 上皮間葉転換 EMT ,  シグナル伝達 ,  発現制御 ,  癌 ,  発生・分化 ,  細胞・組織 ,  ゲノム ,  病理学 ,  循環器・高血圧 ,  内科 ,  分子標的治療 ,  TGF-β ,  転移 ,  がん幹細胞 ,  クロマチン ,  ChIP-chip ChIP-seq ,  TGF-beta ユビキチン Arkadia
Research theme for competitive and other funds  (11)：
  • 2022 - 2025 胃がん・大腸がんにおいて変異SMAD4がもたらすエピゲノム制御異常と病態への関与
  • 2019 - 2022 肺線維症における細胞種特異的TGF-β活性化機構の役割
  • 2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
  • 2015 - 2018 Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancers
  • 2012 - 2016 Roles of BMP signaling in maintenance of cell stemness
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Papers (64)：
  • Atsushi Kondo, Aya Shinozaki-Ushiku, Hirofumi Rokutan, Akiko Kunita, Masako Ikemura, Hiroharu Yamashita, Yasuyuki Seto, Genta Nagae, Kenji Tatsuno, Hiroyuki Aburatani, et al. Loss of Viral Genome with Altered Immune Microenvironment During Tumour Progression of Epstein-Barr Virus-Associated Gastric Carcinoma. The Journal of pathology. 2023
  • Tomohiro Ogami, Yusuke Tamura, Kim Toss, Keiko Yuki, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Keiji Miyazawa, Kohei Miyazono, Daizo Koinuma. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. Journal of biochemistry. 2021
  • Yusuke Tamura, Shuichi Tsutsumi, Kohei Miyazono, Daizo Koinuma. PolyI:C attenuates TGF-β signaling to induce cytostasis of surrounding cells by secreted factors in triple-negative breast cancer. Cancer science. 2021
  • Tomohiko Fukuda, Risa Fukuda, Daizo Koinuma, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin. BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells. Cellular signalling. 2021. 110146-110146
  • Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, et al. PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A. Molecular oncology. 2021. 16. 1. 269-288
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MISC (57)：
  • Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
  • 鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
  • 荻窪一貴, 西田純, 西田純, 高橋恵生, 高橋恵生, 森川真大, 森川真大, 江幡正悟, 江幡正悟, 鯉沼代造, et al. Identification of the mechanisms of malignant progression of triple-negative breast cancer via epigenetic changes. 日本癌学会学術総会抄録集(Web). 2022. 81st
  • 江幡正悟, 江幡正悟, 西田純, 宮國昂介, 鯉沼代造, 宮園浩平. 好中球を介した腎がん肺転移の分子メカニズム. 日本癌学会学術総会抄録集(Web). 2021. 80th
  • 宮國昂介, 西田純, 鯉沼代造, 江幡正悟, 宮園浩平. 腎細胞がんはDNAメチル化を介してアポトーシス耐性を獲得する. 日本癌学会学術総会抄録集(Web). 2021. 80th
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Lectures and oral presentations  (9)：
  • Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
    (TGF-β meeting in Uppsala (Uppsala, Sweden). 2017)
  • Genome-wide profiling of TGF-β-related transcription factor footprints.
    (TGF-β meeting in Uppsala (Uppsala, Sweden). 2015)
  • Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
    (FASEB Summer Research Conference (Snowmass, CO, USA). 2015)
  • Genome-wide identification of Smad2/3 binding regions during TGF-β-induced epithelial to mesenchymal transition in NMuMG cells.
    (FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)
  • Epigenomic mechanism of TGF-β induced transcriptional repression.
    (FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)
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Education (2)：
  • - 2004 Tohoku University
  • - 1997 Tohoku University Faculty of Medicine
Professional career (1)：
  • 博士(医学) (東北大学)
Work history (12)：
  • 2022/08 - 現在 東京大学 大学院医学系研究科 人体病理学・病理診断学分野 准教授
  • 2014/02 - 2022/07 東京大学 大学院医学系研究科 分子病理学分野 准教授
  • 2016/02 - 2019/03 スウェーデン ウプサラ大学 客員研究員(非常勤)
  • 2012/07 - 2014/01 東京大学 大学院医学系研究科 分子病理学分野・リーディング大学院 特任准教授
  • 2009/09 - 2012/06 東京大学 大学院医学系研究科 分子病理学分野 講師
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Committee career (1)：
  • 2016/01 - 現在 日本癌学会 評議員
Awards (3)：
  • 2014 - 日本医師会医学研究奨励賞
  • 2009 - 日本癌学会 奨励賞
  • 2004 - 東北大学 総長賞
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