Koinuma Daizo

Affiliation and department：
Homepage URL (1)： http://pathol.umin.ac.jp/w/

Research field (5)： Respiratory medicine , Cell biology , Molecular biology , Genetics , Biological, health, and medical informatics

Research keywords (14)：上皮間葉転換 EMT , シグナル伝達 , 発現制御 , 癌 , 発生・分化 , 細胞・組織 , ゲノム , 病理学 , 内科 , 分子標的治療 , TGF-β , 転移 , クロマチン , ChIP-chip ChIP-seq

Research theme for competitive and other funds (12)：

2024 - 2027 Molecular characterization of gastric carcinoma with a primitive phenotype
2022 - 2025 胃がん・大腸がんにおいて変異SMAD4がもたらすエピゲノム制御異常と病態への関与
2019 - 2022 Role of a cell type-specific mechanism of TGF-beta signaling activation in lung fibrosis
2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
2015 - 2018 Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancers

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Papers (63)：

Yuka Itoh, Kunio Miyake, Daizo Koinuma, Chiho Omata, Masao Saitoh, Keiji Miyazawa. Analysis of the DNA-binding properties of TGF-β-activated Smad complexes unveils a possible molecular basis for cellular context-dependent signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024. 38. 15. e23877
山本周, 鯉沼代造, 田中麻理子, 牛久哲男. 腹腔内Calcifying fibrous tumorの成因に関する分子病理学的探索. 日本病理学会会誌. 2024. 113. 1. 311-311
Atsushi Kondo, Aya Shinozaki-Ushiku, Hirofumi Rokutan, Akiko Kunita, Masako Ikemura, Hiroharu Yamashita, Yasuyuki Seto, Genta Nagae, Kenji Tatsuno, Hiroyuki Aburatani, et al. Loss of Viral Genome with Altered Immune Microenvironment During Tumour Progression of Epstein-Barr Virus-Associated Gastric Carcinoma. The Journal of pathology. 2023. 260. 2. 124-136
Kazuki Takahashi, Katarzyna A. Podyma-Inoue, Maki Saito, Shintaro Sakakitani, Akinari Sugauchi, Keita Iida, Sadahiro Iwabuchi, Daizo Koinuma, Kyoko Kurioka, Toru Konishi, et al. TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3. Cell Reports. 2022. 40. 13. 111411-111411
Tomohiro Ogami, Yusuke Tamura, Kim Toss, Keiko Yuki, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Keiji Miyazawa, Kohei Miyazono, Daizo Koinuma. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. Journal of biochemistry. 2021

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MISC (63)：

岡本なつめ, 鯉沼代造, 山本周, 九嶋亮治, 牛久哲男. 胎児形質胃癌のアクセシブルクロマチン領域の解析. 日本病理学会会誌. 2023. 112. 1. 386-386
山本周, 鯉沼代造, 国田朱子, 牛久哲男. 家族性大腸腺腫症をモデルとした胃腫瘍発生における腸上皮化生の意義に関する研究. 日本病理学会会誌. 2023. 112. 1. 173-173
井上カタジナアンナ, 高橋和樹, 須河内昭成, 飯田渓太, 岩淵禎弘, 鯉沼代造, 栗岡恭子, 小西徹, 田中晋, 戒田篤志, et al. がん研究における女性研究者 TGF-βは増殖が低下して運動能が上昇したがん細胞集団を形成することで口腔がんの転移を亢進する(TGF-β enhances metastasis of oral cancer via generation of a population of cancer cells in G1 phase with high motility). 日本癌学会総会記事. 2022. 81回. SS1-5
Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st

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Lectures and oral presentations (9)：

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2017)
Genome-wide profiling of TGF-β-related transcription factor footprints.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2015)
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(FASEB Summer Research Conference (Snowmass, CO, USA). 2015)
Genome-wide identification of Smad2/3 binding regions during TGF-β-induced epithelial to mesenchymal transition in NMuMG cells.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)
Epigenomic mechanism of TGF-β induced transcriptional repression.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)

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Education (2)：

- 2004 Tohoku University
- 1997 Tohoku University Faculty of Medicine

Professional career (1)：

博士(医学) (東北大学)

Work history (12)：

2022/08 - 現在東京大学大学院医学系研究科人体病理学・病理診断学分野准教授
2014/02 - 2022/07 東京大学大学院医学系研究科分子病理学分野准教授
2016/02 - 2019/03 スウェーデンウプサラ大学客員研究員(非常勤)
2012/07 - 2014/01 東京大学大学院医学系研究科分子病理学分野・リーディング大学院特任准教授
2009/09 - 2012/06 東京大学大学院医学系研究科分子病理学分野講師

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Committee career (1)：

2016/01 - 現在日本癌学会評議員

Awards (3)：

2014 - 日本医師会医学研究奨励賞
2009 - 日本癌学会奨励賞
2004 - 東北大学総長賞

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