Research field (6):
Experimental pathology
, Respiratory medicine
, Cell biology
, Molecular biology
, Genetics
, Biological, health, and medical informatics
2019 - 2022 Role of a cell type-specific mechanism of TGF-beta signaling activation in lung fibrosis
2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
2015 - 2018 Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancers
2012 - 2016 Roles of BMP signaling in maintenance of cell stemness
2010 - 2016 Effects of TGF-beta family on cancer microenvironment and strategies for cancer therapy
2012 - 2015 Cistromic analysis of EMT regulators in breast cancer cells
2010 - 2011 ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertension
2008 - 2009 Role of lung cancer cells to fibrosis and regulation of TGF-beta signaling by EGF
2005 - 2009 Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
2006 - 2007 呼吸器悪性腫瘍におけるTGF-βシグナル調節性E3ユビキチンリガーゼの役割
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Papers (66):
Aya Shinozaki-Ushiku, Daizo Koinuma, Atsuhito Nakayama, Junichi Nawa, Mitsuhiro Fujishiro, Tetsuo Ushiku. Diffuse Cyclin D1 and SPINK1 Expression in Gastric Oxyntic Gland Neoplasms: Promising Diagnostic Markers Identified by Spatial Transcriptome Analysis. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2025. 100719-100719
Yuka Itoh, Kunio Miyake, Daizo Koinuma, Chiho Omata, Masao Saitoh, Keiji Miyazawa. Analysis of the DNA-binding properties of TGF-β-activated Smad complexes unveils a possible molecular basis for cellular context-dependent signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2024. 38. 15. e23877
井上 カタジナアンナ, 高橋 和樹, 須河内 昭成, 飯田 渓太, 岩淵 禎弘, 鯉沼 代造, 栗岡 恭子, 小西 徹, 田中 晋, 戒田 篤志, et al. がん研究における女性研究者 TGF-βは増殖が低下して運動能が上昇したがん細胞集団を形成することで口腔がんの転移を亢進する(TGF-β enhances metastasis of oral cancer via generation of a population of cancer cells in G1 phase with high motility). 日本癌学会総会記事. 2022. 81回. SS1-5
Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2017)
Genome-wide profiling of TGF-β-related transcription factor footprints.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2015)
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(FASEB Summer Research Conference (Snowmass, CO, USA). 2015)
Genome-wide identification of Smad2/3 binding regions during TGF-β-induced epithelial to mesenchymal transition in NMuMG cells.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)
Epigenomic mechanism of TGF-β induced transcriptional repression.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)