2017 - 2022 Molecular mechanisms of cell differentiation and diversity by TGF-beta family members
2015 - 2018 Changes in the binding regions of Smads downstream of TGF-beta signaling in diffuse type gastric cancers
2012 - 2016 Roles of BMP signaling in maintenance of cell stemness
2010 - 2016 Effects of TGF-beta family on cancer microenvironment and strategies for cancer therapy
2012 - 2015 Cistromic analysis of EMT regulators in breast cancer cells
2010 - 2011 ChIP-seq analysis of transcriptional regulation by BMP in relation to pulmonary hypertension
2008 - 2009 Role of lung cancer cells to fibrosis and regulation of TGF-beta signaling by EGF
2005 - 2009 Establishment of New Strategies for Treatment of Cancer Using TGF-beta Signaling
2006 - 2007 呼吸器悪性腫瘍におけるTGF-βシグナル調節性E3ユビキチンリガーゼの役割
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Papers (64):
Atsushi Kondo, Aya Shinozaki-Ushiku, Hirofumi Rokutan, Akiko Kunita, Masako Ikemura, Hiroharu Yamashita, Yasuyuki Seto, Genta Nagae, Kenji Tatsuno, Hiroyuki Aburatani, et al. Loss of Viral Genome with Altered Immune Microenvironment During Tumour Progression of Epstein-Barr Virus-Associated Gastric Carcinoma. The Journal of pathology. 2023
Tomohiro Ogami, Yusuke Tamura, Kim Toss, Keiko Yuki, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Keiji Miyazawa, Kohei Miyazono, Daizo Koinuma. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. Journal of biochemistry. 2021
Yusuke Tamura, Shuichi Tsutsumi, Kohei Miyazono, Daizo Koinuma. PolyI:C attenuates TGF-β signaling to induce cytostasis of surrounding cells by secreted factors in triple-negative breast cancer. Cancer science. 2021
Tomohiko Fukuda, Risa Fukuda, Daizo Koinuma, Aristidis Moustakas, Kohei Miyazono, Carl-Henrik Heldin. BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells. Cellular signalling. 2021. 110146-110146
Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, et al. PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A. Molecular oncology. 2021. 16. 1. 269-288
Kazuki Takahashi, Katarzyna A. Inoue, Shintaro Sakakitani, Toru Konisi, Akinari Sugauchi, Maki Saito, Atsushi Kaida, Daizo Koinuma, Yasuhiro Yoshimatsu, Toshihiro Uchihashi, et al. Oral cancer cells under TGF-beta-induced cell cycle arrest exhibit motile phenotypes through induction of EMT. CANCER SCIENCE. 2022. 113. 910-910
鯉沼代造, 田村佑介, 森川真大, 森川真大, 堤修一, 田邉諒, 田邉諒, 宮園浩平, 宮園浩平. PolyI:C attenuates TGF-β signaling to induce pyroptotic and cytostatic programs in triple-negative breast cancer. 日本癌学会学術総会抄録集(Web). 2022. 81st
荻窪一貴, 西田純, 西田純, 高橋恵生, 高橋恵生, 森川真大, 森川真大, 江幡正悟, 江幡正悟, 鯉沼代造, et al. Identification of the mechanisms of malignant progression of triple-negative breast cancer via epigenetic changes. 日本癌学会学術総会抄録集(Web). 2022. 81st
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2017)
Genome-wide profiling of TGF-β-related transcription factor footprints.
(TGF-β meeting in Uppsala (Uppsala, Sweden). 2015)
Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.
(FASEB Summer Research Conference (Snowmass, CO, USA). 2015)
Genome-wide identification of Smad2/3 binding regions during TGF-β-induced epithelial to mesenchymal transition in NMuMG cells.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)
Epigenomic mechanism of TGF-β induced transcriptional repression.
(FASEB Summer Research Conference (Steamboat Springs, CO, USA). 2013)