Rchr
J-GLOBAL ID：200901012456728479
Update date: Sep. 28, 2024
Yoshito Abe
アベ ヨシト | Yoshito Abe
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Pharmaceuticals - analytical and physicochemistry
, Biophysics
, Structural biochemistry
Research keywords (9)：
P2X受容体
, DNA複製
, antibody
, NMR
, 構造生物学
, タンパク質
, Structural biology
, Protein engineering
, Protein chemistry
Research theme for competitive and other funds (22)：
- 2021 - 2024 Improvement of protein expression by Escherichia coli based on the structure of anti-P2X4 antibody Fab and development of its additional function.
- 2019 - 2022 鶏卵由来ペプチドのアミロイド線維形成阻止機構の解明と疾患予防効果の検証
- 2018 - 2021 P2X4に対する高親和性抗体を利用した痛みを抑制する誘導体化抗体の開発
- 2014 - 2018 Establishment of research foundation on "objective pain assessment" using animal models suffering from neuropathic pain
- 2015 - 2017 Fundamental Study on Preparations for Therapeutic Antibodies with Less Productions of Anti-Drug Antibodies
- 2014 - 2017 Functional regulation for nucleoprotein complexes in the chromosomal replication origin and in novel regulatory elements, DARS and datA
- 2014 - 2017 Analysis of molecular association and dissociation mechanism in replication restart
- 2011 - 2014 Study on the development of molecules for depressing neuropathic pain based on tertiary structure of human P2X4 receptor
- 2011 - 2013 Structural basis of replication restart primosome proteins involved in DnaB helicase loading
- 2011 - 2012 Development of Fab molecule with the stable scaffold for next generation
- 2008 - 2010 Improved function of ketoamine oxidase for clinical examination reagent of diabetes by use of multiple approaches
- 2008 - 2010 Interaction analysis of chromosomal replication related proteins in Escherichia coli.
- 2007 - 2008 High-order Structure-based Molecular Mechanisms in Replicational Initiation Complex Formation, DNA Unwinding, and Dissociation
- 2006 - 2007 Functional analysis based on the structure of DNA replication proteins in Escherichia coli
- 2004 - 2005 Development of a new assay system for protein S/protein C and treatment of thrombophilia.
- 2002 - 2003 Analysis on mechanism of severe allergic reaction caused by SNP in interleukin 13 using NMR
- 2002 - 2003 赤血球膜タンパク質band3の構造解析
- 2002 - 2002 核磁気共鳴装置を用いたβアミロイドペプチドのリン酸イオンによる凝集抑制機構の解明
- 2002 - 2002 膜タンパク質の膜貫通領域におけるタンパク質-タンパク質相互作用の検出
- 2001 - 2002 A role of Holliday structure in mitochondrial genome maintenance
- 2001 - 2001 膜タンパク質の膜貫通領域におけるタンパク質-タンパク質相互作用の検出
- 2000 - 2001 AnaIysis of dynamic behavior of ribonuclease upon ligand binding using high resolution NMR
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Papers (87)：
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Shogo Inoue, Yohei Ikeda, Saki Fujiyama, Tadashi Ueda, Yoshito Abe. Oligomeric state of the N-terminal domain of DnaT for replication restart in Escherichia coli. Biochimica et biophysica acta. Proteins and proteomics. 2023. 1871. 5. 140929-140929
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Yukiko Muroi, Izumi Aburaya, Yuki Kiyokawa, Keiichi Watanabe, Koji Wada, Yoshito Abe, Yasushi Sugimoto. Stability of hen egg-white lysozyme during embryonic development. Bioscience, biotechnology, and biochemistry. 2022
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Masayuki Oda, Tomoki Sano, Yuji O Kamatari, Yoshito Abe, Teikichi Ikura, Nobutoshi Ito. Structural Analysis of Hen Egg Lysozyme Refolded after Denaturation at Acidic pH. The protein journal. 2022. 41. 1. 71-78
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Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M M Caaveiro, Yoshito Abe, Tadashi Ueda. Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis. Biochemical and biophysical research communications. 2022. 596. 22-28
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Chinatsu Shinozaki, Keita Kohno, Mitsunori Shiroishi, Daisuke Takahashi, Yu Yoshikawa, Yoshito Abe, Kenji Hamase, Makoto Nakakido, Kohei Tsumoto, Kazuhide Inoue, et al. Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions. Scientific reports. 2022. 12. 1. 131-131
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MISC (23)：
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阿部 義人. ATP受容体P2X4に対する抗体とATP加水分解酵素を利用した「痛み」抑制分子の開発. 日本応用酵素協会誌. 2019. 53. 34-34
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植田正, 大栗誉敏, 阿部義人, 村上茂. 試験管内における蛋白質の凝集抑制に及ぼすタウリンの効果. タウリンリサーチ. 2018. 4. 1. 6-8-8
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阿部義人, 植田正. 低分子による抗体軽鎖変異体の安定化とアミロイド繊維形成の抑制 タンパク質安定化はアミロイド形成を抑制する. 化学と生物. 2017. 55. 5. 311-312
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阿部義人. Catalytic Mechanism of Lysozyme Based on the Structures of Invertebrate-type Lysozyme and Chicken-type Lysozyme. 生物物理(Web). 2017. 57. 3. 140-143(J-STAGE)
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Tanana T, Fujisaki, N, Maeda, M, Abe, Y, Ueda, T, Kimura, Y. Free N-glycans modulate protein folding. Glycoconjugate Journal. 2015. 32. 193
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Lectures and oral presentations (28)：
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抗P2X4抗体Fabの立体構造を基盤とした大腸菌発現系の改良
(第23回日本蛋白質科学年会 2023)
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立体構造を基盤としたantiP2X4抗体Fab生産法の改良
(第12回国際医療福祉大学学会学術大会 2022)
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ATP受容体P2X4の機能を抑制する誘導体化抗体の創製
(第11回国際医療福祉大学学会学術大会 2021)
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Evaluation of stability and function of DnaT oligomeric structure of E. coli replication restart
(2020)
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大腸菌による可溶性抗P2X4受容体Fabの発現系の構築
(第93回日本生化学会大会 2020)
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Education (2)：
- - 1996 Kyushu University
- - 1991 Kyushu University School of Pharmaceutical Sciences
Professional career (1)：
Work history (5)：
- 2020/04 - International University of Health and Welfare Faculty of Pharmaceutical Science in Fukuoka Professor
- 2007/04 - 2020/03 Gradate School of Pharmaceutical Science Laboratory of Protein structure, function and design Associate Professor
- 2003 - 2007 Kyushu University Faculty of Pharmaceutical Sciences
- 1999 - 2003 Kyushu University Faculty of Medical Sciences
- 1996 - 1999 生物分子工学研究所 博士研究員
Committee career (1)：
- 2009/04 - 2010/03 生化学会雑誌「生化学」企画協力委員.
Awards (3)：
- 2022/11 - 日本生化学会 JB審査員賞
- 2005 - 日本生化学会九州支部学術奨励賞
- 2001 - 福岡医学会賞
Association Membership(s) (5)：
日本蛋白質科学会
, 日本生物物理学会
, 日本分子生物学会
, 日本生化学会
, 日本薬学会
