Rchr
J-GLOBAL ID：200901012598147805   Update date: Feb. 01, 2024

Saga Yumiko

サガ ユミコ | Saga Yumiko
Affiliation and department：
National Institute of Genetics

About National Institute of Genetics


Homepage URL  (1)： http://www.nig.ac.jp/labs/ManDev/home-j.html
Research field  (1)： Laboratory animal science
Research keywords  (4)： 分子生物学 ,  発生遺伝学 ,  Molecular Biology ,  Developmental Genetics
Research theme for competitive and other funds  (34)：
  • 2017 - 2022 Mechanism of sex differentiation of germ cells
  • 2016 - 2019 Analysis of regulating mechanism for development and differentiation of special cardiomyocytes
  • 2017 - 2018 生殖細胞の性分化機構
  • 2013 - 2018 Regulation of epigenome dynamics and regulation in germ cells
  • 2013 - 2017 Establishment of sexual epigenome of germ cell via RNA-mediated mechanism
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Papers (161)：
  • Wataru Masuda, Tomoko Yamakawa, Rieko Ajima, Katsuya Miyake, Toshifumi Umemiya, Kazuhiko Azuma, Jun-Ichi Tamaru, Makoto Kiso, Puspa Das, Yumiko Saga, et al. TM2D3, a mammalian homologue of Drosophila neurogenic gene product Almondex, regulates surface presentation of Notch receptors. Scientific reports. 2023. 13. 1. 20913-20913
  • Yusuke Watanabe, Yunce Wang, Yuki Tanaka, Akiyasu Iwase, Teruhisa Kawamura, Yumiko Saga, Kenta Yashiro, Hiroki Kurihara, Osamu Nakagawa. Hey2 enhancer activity defines unipotent progenitors for left ventricular cardiomyocytes in juxta-cardiac field of early mouse embryo. Proceedings of the National Academy of Sciences. 2023. 120. 37
  • Yuzuru Kato, Yumiko Saga. Antagonism between DDX6 and PI3K-AKT signaling is an oocyte-intrinsic mechanism controlling primordial follicle growth. Biology of reproduction. 2023
  • Adithya Dhamodharan, Hajime Okada, Masafumi Muraoka, Danelle Wright, Akemi Okubo, Yumiko Saga. P-body dynamics revealed by DDX6 protein knockdown via the auxin-inducible degron system. Development, growth & differentiation. 2022
  • Jessica Kim, Masafumi Muraoka, Hajime Okada, Atsushi Toyoda, Rieko Ajima, Yumiko Saga. The RNA helicase DDX6 controls early mouse embryogenesis by repressing aberrant inhibition of BMP signaling through miRNA-mediated gene silencing. PLoS genetics. 2022. 18. 10. e1009967
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MISC (61)：
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Books (1)：
  • 実験医学(増刊)「発生・分化・再生研究2005」,23 Notchシグナルの多様性
    2005
Lectures and oral presentations  (282)：
  • NANOS2 recognizes its target RNA together with the RNA-DND1 complex to make a functional complex in the male germ cells of mice
    (2020)
  • IDENTIFICATION OF NANOS2 TARGET TO SUPPRESS CELL CYCLE IN MURINE MALE GERM CELLS USING scRNA-SEQ
    (CSH-germ meeting 2020)
  • NANOS2 RECOGNIZES THE TARGET RNA TOGETHER WITH THE RNA-DND1 COMPLEX TO MAKE A FUNCTIONAL COMPLEX IN MURINE MALE GERM CELLS
    (CSH-germ meeting 2020)
  • マウスgermline stem cellsを用いたNANOS3の機能解析
    (日本繁殖生物学会 2020)
  • DDX6-mediated mRNA regulation is required for the mesoderm specification during early embryogenesis in mice
    (JSDB 2020)
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Education (4)：
  • University of Tsukuba
  • 筑波大学大学院 生物科学研究科 生物物理化学専攻
  • University of Tsukuba
  • Doctoral Program in Biological Sciences, University of Tsukuba
Professional career (1)：
  • Doctor of Science
Work history (24)：
  • 2022/04 - National Institute of Genetics
  • 2000 - :国立遺伝学研究所・系統生物研究センター・教授
  • 2000 - : National Institute of Genetics.
  • 1997 - :国立医薬品食品衛生研究所・毒性部・第4研究室・室長
  • 1997 - :国立医薬品食品衛生研究所・毒性部・第4研究室・主任研究官
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Association Membership(s) (4)：
日本分子生物学会 ,  日本発生生物学会 ,  The Molecular Biology Society of Japan ,  The Japanese Society of Developmental Biologists
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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