KASHIWABARA Shin-ichi

カシワバラシンイチ | KASHIWABARA Shin-ichi

Affiliation and department：
Job title： Associate Professor

Research field (2)： Developmental biology , Applied molecular and cellular biology

Research keywords (5)： translational regulation , translation , post-transcriptional gene regulation , poly(A) tail , gametogenesis

Research theme for competitive and other funds (15)：

2024 - 2027 Multifaced approach toward the understanding of mechanism of spermatogenesis mediated by mRNA poly(A) tail
2021 - 2024 精子形成減数分裂期以降における完全な翻訳抑制と部分的な翻訳抑制の機構
2018 - 2021 哺乳動物精子形成後期に特徴的な翻訳遅延と脱アデニル化の機構
2013 - 2015 RNase H2 is essential for ribonucleotide excision repair during DNA replication
2011 - 2012 クロマトイドボディおよびmRNP構成因子の精子形成における役割

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Papers (61)：

Kaku, Yuko, Isono, Yuka, Tanaka, Hideto, Kobayashi, Tomohiro, Kanemori, Yoshinori, Kashiwabara, Shin-Ichi. Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(a)-binding protein but is dispensable for spermatogenesis in the mouse. Biology of reproduction. 2024. 110. 4. 834-847
Oyama, Kanako, Baba, Tadashi, Kashiwabara, Shin-Ichi. Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation. Journal of Reproduction and Development. 2020. 67. 1. 35-42
Kim, Jaehyun, Nakamura, Junnosuke, Hamada, Chiharu, Taketomi, Takumi, Yano, Sarasa, Okajima, Tomomi, Kashiwabara, Shin-Ichi, Baba, Tadashi, Sato, Ban, Chiba, Tomoki, et al. USP15 deubiquitinates TUT1 associated with RNA metabolism and maintains cerebellar homeostasis. Mol Cell Biol. 2020. 40. 21. e00098-20
Kokubu, Daichi, Ooba, Ryousuke, Abe, Yukiko, Ishizaki, Hana, Yoshida, Shigeki, Asano, Atsushi, Kashiwabara, Shin-Ichi, Miyazaki, Hitoshi. Angelica keiskei (Ashitaba) powder and its functional compound xanthoangelol prevent heat stress-induced impairment in sperm density and quality in mouse testes. Journal of Reproduction and Development. 2019. 65. 2. 139-146
Kashiwabara, Shin-Ichi, Tsuruta, Satsuki, Yamaoka, Yutaro, Oyama, Kanako, Iwazaki, Chieko, Baba, Tadashi. PAPOLB/TPAP regulates spermiogenesis independently of chromatoid body-associated factors. Journal of Reproduction and Development. 2018. 64. 1. 25-31

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Books (3)：

Regulation of spermatogenesis by polyadenylation and deadenylation of mRNAs
蛋白質核酸酵素・共立出版 2009
半数体精細胞特異的遺伝子の発現制御
生化学 2005
精巣特異的ポリ(A)ポリメラーゼTPAPによる精子形態形成制御
日本疾患モデル学会誌 2004

Lectures and oral presentations (31)：

ヒト精子におけるミトコンドリアタンパク質COXFA4L3の二重局在
(第46回日本分子生物学会年会)
マウス卵巣におけるRNA結合タンパク質TB-RBPの分子機能解析
(第46回日本分子生物学会年会)
レトロポゾンに由来する精巣特異的ポリ(A)鎖結合タンパク質PABPC2とPABPC6の双方を欠損するマウスの精子形成は正常である
(第46回日本分子生物学会年会)
マウス精巣特異的ポリ(A)鎖結合タンパク質PABPC6を欠損するマウスの精子形成は正常である
(第46回日本分子生物学会年会)
Testis-specific cytoplasmic poly(A)-binding protein PABPC6 is encoded by a retroposed gene in the mouse.
(第45回日本分子生物学会年会 2022)

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Education (2)：

- 1993 University of Tsukuba Graduate School, Division of Agriculture
- 1988 University of Tsukuba Second Cluster of College

Work history (8)：

2007/04 - 現在筑波大学大学院生命環境科学研究科准教授
2004/04 - 2007/03 筑波大学大学院生命環境科学研究科助教授
2003/04 - 2004/03 University of Tsukuba Institute of Applied Biochemistry
1999/05 - 2003/03 University of Tsukuba Institute of Applied Biochemistry
1998/04 - 1999/04 University of Tsukuba Institute of Applied Biochemistry

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Committee career (4)：

2023/04 - 2024/03 筑波大学生物資源学類応用生命化学コース領域主任
2023/04 - 2024/03 筑波大学生物資源学類運営委員会
2023/04 - 2024/03 筑波大学生物資源学類教育課程委員会
2020/04 - 2022/03 筑波大学放射線管理委員会委員

Awards (3)：

2003 - 財団法人東京生化学研究会東京生化学研究会研究助成
2003 - 財団法人上原記念生命科学財団上原記念生命科学財団研究助成
2003 - 財団法人ノバルティス科学振興財団ノバルティス研究奨励助成

Association Membership(s) (4)：

THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT , THE RNA SOCIETY OF JAPAN , The Molecular Biology Society of Japan , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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