Osamu Nagano

ナガノオサム | Osamu Nagano

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://gene-reg.jp/

Research field (1)： Pathobiochemistry

Research keywords (1)： Tumor biology

Research theme for competitive and other funds (8)：

2021 - 2024 Elucidation of mechanisms of xCT-mediated cancer therapy resistance accompanied with metabolic reprograming and cancer stem cell property
2021 - 2023 Development of the therapy targeted to the vulnerability of SMARCA4-mutant lung cancer cells to ferroptosis
2017 - 2020 Elucidation of the mechanism of the induction of ferroptosis by xCT inhibitor and its antitumor effect in small cell lung cancer
2016 - 2018 Development of therapeutic strategry breaking resistance to oxidative stress in glioma
2012 - 2015 Development of cancer therapy targeting the metabolism activated by EpCAM in cancer stem cells.

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Papers (93)：

Jun Zhang, Lingfeng Fu, Huaitao Wang, Atsuko Yonemura, Takashi Semba, Noriko Yasuda-Yoshihara, Akiho Nishimura, Takuya Tajiri, Yilin Tong, Tadahito Yasuda, et al. RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. Cancer letters. 2024. 591. 216901-216901
Atsuko Yonemura, Takashi Semba, Jun Zhang, Yibo Fan, Noriko Yasuda-Yoshihara, Huaitao Wang, Tomoyuki Uchihara, Tadahito Yasuda, Akiho Nishimura, Lingfeng Fu, et al. Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment. Cell reports. 2024. 43. 1. 113613-113613
Fumimasa Kitamura, Takashi Semba, Noriko Yasuda-Yoshihara, Kosuke Yamada, Akiho Nishimura, Juntaro Yamasaki, Osamu Nagano, Tadahito Yasuda, Atsuko Yonemura, Yilin Tong, et al. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI insight. 2023. 8. 20
今枝慶蓉, 増田健太, 永井晋平, 田村友宏, 杉原英志, 山崎淳太郎, 大槻雄士, 信末博行, 千代田達幸, 小林佑介, et al. 新規マウスモデルを用いた高異型度漿液性癌の予後不良に関連するバイオマーカーの同定(Identification of biomarkers associated to poor prognosis in high-grade serous carcinoma using novel mouse models). 日本癌学会総会記事. 2023. 82回. 1044-1044
増田健太, 阪埜浩司, 青木大輔, 山上亘, 佐谷秀行, 永野修. 乳癌・卵巣癌研究の最前線遺伝子改変オルガノイドモデルとヒトサンプルを用いた化学療法後の卵巣癌残存腫瘍細胞の解析(Frontiers of Breast and Ovarian Cancers Analysis of residual ovarian cancer cells using the genetically engineered organoids model and human samples). 日本癌学会総会記事. 2023. 82回. 1652-1652

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MISC (64)：

Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano. Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer. CANCER SCIENCE. 2022. 113. 1324-1324
永井晋平, 増田健太, 田村友宏, 大槻雄士, 推名健太郎, 信末博行, 赤羽智子, 千代田達幸, 小林佑介, 阪埜浩司, et al. p53の機能障害はマウス卵管オルガノイドの分化を阻害する. 日本癌学会総会記事. 2021. 80回. [J5-6]
Shintaro Nakamura, Hiroyuki Ozawa, Juntaro Yamasaki, Shogo Okazaki, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Osamu Nagano, Mariko Sekimizu, Shin Saito, et al. Pimozide combined with paclitaxel demonstrates a significant antitumor effect in head and neck squamous cell carcinoma. CANCER RESEARCH. 2020. 80. 16
推名健太郎, 山崎淳太郎, 大槻雄士, 平田雄紀, 岡崎章悟, 土橋賢司, サンペトラ・オルテア, 光石陽一郎, 高橋史行, 高橋和久, et al. 小細胞肺癌において、xCTはがん幹細胞性に寄与する(xCT confers cancer stem-like properties in small cell lung cancer cells). 日本癌学会総会記事. 2019. 78回. E-1102
Shohei Kamenori, Kentaro Suina, Juntaro Yamasaki, Subaru Shintani, Yuji Otsuki, Yuki Hirata, Shogo Okazaki, Kenji Tsuchihashi, Oltea Sampetrean, Yoichiro Mitsuishi, et al. SLC7A11 expression confers cancer stem-like properties in small cell lung cancer cells. CANCER RESEARCH. 2019. 79. 13

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Patents (5)：

抗腫瘍剤及び配合剤
抗腫瘍剤及び配合剤
がん幹細胞の増殖抑制剤および細胞内活性酸素蓄積誘導剤
ダイヤモンドマイクロ電極を用いた生体内pH測定装置及び方法
ダイヤモンド微小電極を用いた還元型グルタチオンの測定装置

Lectures and oral presentations (65)：

がん幹細胞、治療抵抗性腫瘍、ドラッグリポジショニングの基礎
(第111回日本泌尿器科学会総会卒後教育プログラム 2024)
がんのフェロトーシス回避機構と新規治療法の開発
(第38回 Wakoワークショップ「シン・がん医療:新技術に裏打ちされたがんの基礎と臨床」 2023)
シスチントランスポーターxCTとALDHを標的とした新しいがん治療
(日本薬物動態学会(JSSX)第37回年会 2022)
Development of ferroptosis-inducing therapy for chemoresistant cancer
(Redox Week in Sendai 2022 2022)
Development of cancer therapy by simultaneous targeting of cystine-glutamate antiporter xCT and aldehyde dehydrogenase
(CSHA meeting on Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease, AWAJI, JAPAN 2022 2022)

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Education (2)：

2001 - 2005 Kumamoto University School of medicine
1993 - 1999 Hiroshima University Faculty of dentistry

Professional career (1)：

医学博士 (熊本大学)

Work history (5)：

2023/04 - 現在 Fujita Health University Division of Gene Regulation, Oncology Innovation Center Professor
2018/05 - 2023/03 Keio University School of Medicine associate professor
2012/04 - 2018/04 Keio University School of Medicine assistant professor
2007/04 - 2012/03 Keio University School of Medicine assistant professor
1999/06 - 2001/03 Kyushu University Faculty of Dental Science resident

Awards (1)：

2011/10 - Japanese cancer association Incitement Award of the Japanese Cancer Association 癌幹細胞マーカーCD44の機能解析

Association Membership(s) (2)：

Japanese Cancer Association , 日本分子生物学会

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