Osamu Nagano

ナガノオサム | Osamu Nagano

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://gene-reg.jp/

Research field (1)： Pathobiochemistry

Research keywords (1)： Tumor biology

Research theme for competitive and other funds (8)：

2021 - 2024 Elucidation of mechanisms of xCT-mediated cancer therapy resistance accompanied with metabolic reprograming and cancer stem cell property
2021 - 2023 Development of the therapy targeted to the vulnerability of SMARCA4-mutant lung cancer cells to ferroptosis
2017 - 2020 Elucidation of the mechanism of the induction of ferroptosis by xCT inhibitor and its antitumor effect in small cell lung cancer
2016 - 2018 Development of therapeutic strategry breaking resistance to oxidative stress in glioma
2012 - 2015 Development of cancer therapy targeting the metabolism activated by EpCAM in cancer stem cells.

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Papers (99)：

Taiju Ando, Juntaro Yamasaki, Hideyuki Saya, Osamu Nagano. CD44: A Key Regulator of Iron Metabolism, Redox Balance, and Therapeutic Resistance in Cancer Stem Cells. Stem Cells. 2025
Tomohiro Tamura, Shimpei Nagai, Kenta Masuda, Keiyo Imaeda, Eiji Sugihara, Juntaro Yamasaki, Miho Kawaida, Yuji Otsuki, Kentaro Suina, Hiroyuki Nobusue, et al. mTOR-mediated p62/SQSTM1 stabilization confers a robust survival mechanism for ovarian cancer. Cancer letters. 2025. 217565-217565
Yu Kato, Takeshi Inaba, Koudai Shinke, Noriko Hiramatsu, Tetsuhiro Horie, Takuya Sakamoto, Yuko Hata, Eiji Sugihara, Tetsuya Takimoto, Noriaki Nagai, et al. Comprehensive Search for Genes Involved in Thalidomide Teratogenicity Using Early Differentiation Models of Human Induced Pluripotent Stem Cells: Potential Applications in Reproductive and Developmental Toxicity Testing. Cells. 2025. 14. 3. 215-215
Kazuhiro Fukumura, Akio Masuda, Jun-Ichi Takeda, Osamu Nagano, Hideyuki Saya, Kinji Ohno, Akila Mayeda. RNPS1 in PSAP complex controls periodic pre-mRNA splicing over the cell cycle. iScience. 2024. 27. 12. 111400-111400
Jun Zhang, Lingfeng Fu, Huaitao Wang, Atsuko Yonemura, Takashi Semba, Noriko Yasuda-Yoshihara, Akiho Nishimura, Takuya Tajiri, Yilin Tong, Tadahito Yasuda, et al. RAC1-mediated Integrin alpha-6 expression in E-cadherin-deficient gastric cancer cells promotes interactions with the stroma and peritoneal dissemination. Cancer letters. 2024. 591. 216901-216901

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MISC (64)：

Shogo Okazaki, Yuki Nakano, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Ryo Goitsuka, Hideyuki Saya, Osamu Nagano. Transcription factor FOXA1 is a negative regulator for xCT-dependent tumor formation in oral cancer. CANCER SCIENCE. 2022. 113. 1324-1324
永井晋平, 増田健太, 田村友宏, 大槻雄士, 推名健太郎, 信末博行, 赤羽智子, 千代田達幸, 小林佑介, 阪埜浩司, et al. p53の機能障害はマウス卵管オルガノイドの分化を阻害する. 日本癌学会総会記事. 2021. 80回. [J5-6]
Shintaro Nakamura, Hiroyuki Ozawa, Juntaro Yamasaki, Shogo Okazaki, Momoko Yoshikawa, Tomoya Soma, Seiji Asoda, Osamu Nagano, Mariko Sekimizu, Shin Saito, et al. Pimozide combined with paclitaxel demonstrates a significant antitumor effect in head and neck squamous cell carcinoma. CANCER RESEARCH. 2020. 80. 16
推名健太郎, 山崎淳太郎, 大槻雄士, 平田雄紀, 岡崎章悟, 土橋賢司, サンペトラ・オルテア, 光石陽一郎, 高橋史行, 高橋和久, et al. 小細胞肺癌において、xCTはがん幹細胞性に寄与する(xCT confers cancer stem-like properties in small cell lung cancer cells). 日本癌学会総会記事. 2019. 78回. E-1102
Shohei Kamenori, Kentaro Suina, Juntaro Yamasaki, Subaru Shintani, Yuji Otsuki, Yuki Hirata, Shogo Okazaki, Kenji Tsuchihashi, Oltea Sampetrean, Yoichiro Mitsuishi, et al. SLC7A11 expression confers cancer stem-like properties in small cell lung cancer cells. CANCER RESEARCH. 2019. 79. 13

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Patents (5)：

Lectures and oral presentations (65)：

がん幹細胞、治療抵抗性腫瘍、ドラッグリポジショニングの基礎
(第111回日本泌尿器科学会総会卒後教育プログラム 2024)
がんのフェロトーシス回避機構と新規治療法の開発
(第38回 Wakoワークショップ「シン・がん医療:新技術に裏打ちされたがんの基礎と臨床」 2023)
シスチントランスポーターxCTとALDHを標的とした新しいがん治療
(日本薬物動態学会(JSSX)第37回年会 2022)
Development of ferroptosis-inducing therapy for chemoresistant cancer
(Redox Week in Sendai 2022 2022)
Development of cancer therapy by simultaneous targeting of cystine-glutamate antiporter xCT and aldehyde dehydrogenase
(CSHA meeting on Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease, AWAJI, JAPAN 2022 2022)

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Education (2)：

Professional career (1)：

Work history (5)：

2023/04 - 現在 Fujita Health University Division of Gene Regulation, Oncology Innovation Center Professor
2018/05 - 2023/03 Keio University School of Medicine associate professor
2012/04 - 2018/04 Keio University School of Medicine assistant professor
2007/04 - 2012/03 Keio University School of Medicine assistant professor
1999/06 - 2001/03 Kyushu University Faculty of Dental Science resident

Awards (1)：

2011/10 - Japanese cancer association Incitement Award of the Japanese Cancer Association 癌幹細胞マーカーCD44の機能解析

Association Membership(s) (2)：

Japanese Cancer Association , 日本分子生物学会

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