Rchr
J-GLOBAL ID：200901013357989860   Update date: Apr. 01, 2024

Kurebayashi Nagomi

クレバヤシ ナゴミ | Kurebayashi Nagomi
Affiliation and department：
Juntendo University Faculty of Medicine

About Juntendo University Faculty of Medicine


Homepage URL  (1)： http://pharmacology.sakura.ne.jp/
Research field  (3)： Pharmacology ,  Physiology ,  Cardiology
Research keywords  (6)： Ryanodine receptor ,  arrhythmia ,  Skeletal muscle ,  calcium ,  sarcoplasmic reticulum ,  cardiac muscle
Research theme for competitive and other funds  (34)：
  • 2022 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
  • 2022 - 2025 Development of RyR2-specific inhibitors and activators and their application as antiarrhythmic agents
  • 2022 - 2025 Role of long-term cellular dysfunction due to abnormal Ca2+ metabolism in presbyopia
  • 2021 - 2024 Structural analysis of the gating mechanism of cardiac ryanodine receptor
  • 2021 - 2024 The construction of exercise therapy in familial DCM model mice
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Papers (122)：
  • Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Xi Zeng, Shuichi Mori, Masami Kodama, Takashi Murayama, Hiroyuki Masuno, Fumi Takeda, Masatoshi Kawahata, et al. A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European journal of medicinal chemistry. 2023. 262. 115910-115910
  • Atsushi Hori, Tomohiko Ai, Takashi Hato, Haruka Inaba, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, et al. Carvedilol suppresses ryanodine receptor-dependent Ca2+bursts in human neurons bearingPSEN1variants found in early onset Alzheimer’s disease. 2023
  • Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino, et al. Screening for novel RyR2 inhibitors by ER Ca2+monitoring. Molecular Pharmacology. 2023. MOLPHARM-AR
  • Takashi Murayama, Nagomi Kurebayashi, Ryosuke Ishida, Hiroyuki Kagechika. Drug development for the treatment of RyR1-related skeletal muscle diseases. Current opinion in pharmacology. 2023. 69. 102356-102356
  • Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa, et al. Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. Arrhythmia and electrophysiology. 2023. 16. 3. e011387
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MISC (212)：
  • 野中美希, 上野晋, 柿木亮, 岸田昭世, 呉林なごみ, 村山尚, 櫻井隆, 上園保仁. 回し車を用いた自発運動負荷によるがん悪液質性心機能障害に対する治療効果の検討. 日本腫瘍循環器学会学術集会抄録集(Web). 2021. 4th
  • Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kanemaru Kazunori, Takashi Sakurai, Masamitsu Iino. Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
  • Hirofumi Shimizu, Takuya Kobayashi, Masayuki Iwamoto, Kentaro Kajiwara, Nagomi Kurebayashi, Haruo Ogawa, Takashi Murayama. Single-Molecule Twisting Motions During Gating of the Human TRPV1 Channel Recorded with Sub-Millisecond Time Resolution. BIOPHYSICAL JOURNAL. 2020. 118. 3. 22A-22A
  • Takashi Murayama, Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Satoru Noguchi, Ichizo Nishino, Shuichi Mori, Hiroyuki Kagechika, Jose R. Lopez, Paul D. Allen. Therapeutic Effects of a Novel RyR1 Inhibitor on Malignant Hyperthermia-Susceptible Model Mice. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
  • 杉原匡美, 柿木亮, 村山尚, 平山哲, 三井田孝, 森本幸生, 呉林なごみ. 拡張型心筋症モデルにおける性差による自発運動の効果の違い. 臨床病理. 2020. 68
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Patents (3)：
Books (4)：
  • イラストレイテッド薬理学 原書6版 (リッピンコットシリーズ)(柳澤輝行, 丸山敬 編)
    丸善出版 2016 ISBN:4621301047
  • 不整脈学(井上博, 村川裕二 編)
    南江堂 2012 ISBN:4524269363
  • Ryanodine Receptors: Structure Function and Dysfunction in Clinical Disease.
    Springer-Verlag US 2005 ISBN:9780387231877
  • Calcium releasing action of quercetin on sarcoplasmic reticulum from frog skeletal muscle.
    "Structure and Function of Saroplasmic Reticulum" Academic Press, 1985
Lectures and oral presentations  (12)：
  • The potential of RyR2 inhibitors as a new class of antiarrhythmic drugs,
    (101th Annual Meeting of the Japan Physiological Society 2024)
  • Effects of a high-affinity and selective RyR2 inhibitor on Ca2+ signals in cardiomyocytes and arrhythmias in CPVT model mice
    (BPS 2024 in Philadelphia 2024)
  • Development of RyR2 inhibitors and verification of their effects on CPVT mouse models
    (Australian Physiological Society Conference, 2024 2023)
  • Effects of a novel RyR2 selective inhibitor on malignant arrhythmias in CPVT model mice
    (10th FAOPS Congress 2023 2023)
  • A novel, high-affinity and selective RyR2 inhibitor effectively suppresses lethal arrhythmias in CPVT mouse models
    (Gordon Research Conference, Muscle: Ecxitation Contraction Coupling 2023)
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Work history (7)：
  • 2021/04 - 現在 Juntendo University
  • 2007/04 - 2020/03 Juntendo University
  • 2000 - 2007 Juntendo University
  • 1992 - 2000 Juntendo University
  • 1990 - 1991 ペンシルバニア大学 ポスドク
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Committee career (4)：
  • 2018/03 - 現在 Journal of General Physiology Editorial Advisory Board
  • - 現在 国際心臓研究会(ISHR)日本部会 評議員
  • - 現在 日本生理学会 学術評議員
  • - 現在 日本薬理学会 学術評議員
Association Membership(s) (10)：
International Society for Heart Research ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  Japanese Association of Cardiovascular Pharmacology ,  American Physiologocal Society ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE JAPANESE PHARMACOLOGICAL SOCIETY ,  American Physiological Society ,  The Japanese Physiological Society ,  Biophysical Society
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