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J-GLOBAL ID：200901013412416778   Update date: Nov. 07, 2024

Fujiwara Yasuyuki

フジワラ ヤスユキ | Fujiwara Yasuyuki
Affiliation and department：
Tokyo University of Pharmacy and Life Sciences School of Pharmacy

About Tokyo University of Pharmacy and Life Sciences School of Pharmacy


Job title： Professor
Homepage URL  (1)： https://nrid.nii.ac.jp/nrid/1000040247482/
Research field  (5)： Hygiene and public health (laboratory) ,  Cell biology ,  Molecular biology ,  Pharmaceuticals - health and biochemistry ,  Environmental effects of chemicals
Research keywords  (6)： Heavy Metal Toxicology ,  Proteoglycan ,  Bioorganometalics (BOM) ,  Vascular toxicity ,  Photodynamic Therapy (PDT) ,  Atherosclerosis
Research theme for competitive and other funds  (24)：
  • 2023 - 2026 血管周囲脂肪組織に着目したヒ素の血管毒性発現機構の解明
  • 2020 - 2023 Disruption of blood coagulation and fibrinolysis system by arsenic and elucidation of its possible mechanisms.
  • 2016 - 2019 Mechanisms of vascular disease caused by cadmium and lead mediated by multifunctional protein nucleolin.
  • 2012 - 2015 The functional regulation of metallothionein by functional organic-inorganic hybrid molecules and its molecular mechanism
  • 2009 - 2010 Role of metallothionein on the progression of atherosclerosis and its application to medical care.
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Papers (129)：
  • Tsuyoshi Nakano, Eiko Yoshida, Yu Sasaki, Shigekatsu Kazama, Fumika Katami, Kazuhiro Aoki, Tomoya Fujie, Ke Du, Takato Hara, Chika Yamamoto, et al. Mechanisms Underlying Sensory Nerve-Predominant Damage by Methylmercury in the Peripheral Nervous System. International Journal of Molecular Sciences. 2024. 25. 21. 11672-11672
  • Eiko Yoshida, Kazuhiro Aoki, Yu Sasaki, Hinako Izuhara, Tsutomu Takahashi, Yasuyuki Fujiwara, Tomoya Fujie, Ke Du, Komyo Eto, Yo Shinoda, et al. Comparative study of susceptibility to methylmercury cytotoxicity in cell types composing rat peripheral nerves: a higher susceptibility of dorsal root ganglion neurons. The Journal of Toxicological Sciences. 2024. 49. 5. 241-248
  • Tomoya Fujie, Miyabi Kobayashi, Lihito Ikeuchi, Tsuyoshi Nakano, Kazuki Kitabatake, Yo Shinoda, Yasuyuki Fujiwara, Chika Yamamoto, Mitsutoshi Tsukimoto, Toshiyuki Kaji. Transcriptome analysis of cultured human vascular endothelial cells after γ-ray irradiation and correlation analysis with ATP, ADP, and adenosine as secondary soluble factors. The Journal of Toxicological Sciences. 2024. 49. 4. 193-208
  • Takato Hara, Reina Kumagai, Tohru Tanaka, Tsuyoshi Nakano, Tomoya Fujie, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji. Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI2 pathway in cultured bovine vascular endothelial cells. The Journal of Toxicological Sciences. 2023. 48. 12. 655-663
  • Maki Tokumoto, Jin-Yong Lee, Yasuyuki Fujiwara, Masahiko Satoh. Long-term exposure to cadmium causes hepatic iron deficiency through the suppression of iron-transport-related gene expression in the proximal duodenum. Toxics. 2023. 11. 7. 641
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MISC (23)：
  • Masahiko Satoh, Jin-Yong Lee, Maki Tokumoto, Akiko Honda, Yasuyuki Fujiwara. 【Review】Molecular mechanism of cadmium toxicity and its protection. The Aich-gakuin journal of pharmaceutical sciences. 2020. 13. 1-10
  • Yasuyuki Fujiwara, Masahiko Satoh. 【Review】Protective Role of Metallothionein in Chemical and Radiation Carcinogenesis. Current Pharmaceutical Biotechnology. 2013. 14. 4. 394-399
  • Yasuyuki Fujiwara, Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh. 【Review】Cadmium Renal Toxicity via Apoptotic Pathways. Biological and Pharmaceutical Bulletin. 2012. 35. 11. 1892-1897
  • Yasuyuki FUJIWARA, Tomoki KIMURA. Molecular Toxicology Led by Young Scientists 5-Biological Systems to Determine the Sensitivity to Chemicals-. YAKUGAKU ZASSHI. 2011. 131. 3. 353-354
  • 藤原泰之. メラミンによる食品汚染について. 日本薬学会 環境・衛生部会ホームページ「環境・衛生薬学トピックス」. 2010. 掲載開始
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Patents (1)：
  • 血管平滑筋細胞の増殖抑制剤
Books (9)：
  • 衛生薬学 -健康の維持と増進をめざして-(早川磨紀男,藤原泰之,山折大編集)
    京都廣川書店 2023 ISBN:9784910844091
  • 必携・衛生試験法 第3版(日本薬学会編,藤原泰之編集委員長,佐藤雅彦監修)
    金原出版 2021 ISBN:9784307470506
  • コンパス衛生薬学 改訂第3版:健康と環境(鍜冶利幸・佐藤雅彦編集)
    南江堂 2020 ISBN:9784524403714
  • 衛生試験法・注解2020(日本薬学会編,小椋康光編集委員長,神野透人・藤原泰之副編集委員長)
    金原出版 2020 ISBN:9784307470490
  • 必携・衛生試験法 第2版(日本薬学会編,佐藤雅彦編集委員長)
    金原出版 2016 ISBN:4307470443
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Lectures and oral presentations  (13)：
  • 有害金属の血管毒性発現機構に関する研究
    (フォーラム2024:衛生薬学・環境トキシコロジー 2024)
  • 環境汚染金属による血管内皮細胞の機能障害を介した血管毒性発現機構
    (近畿大学大学院 特別講義 2024)
  • 血液凝固・線溶系に対する亜ヒ酸の毒性発現機構
    (第49回日本毒性学会学術年会・生体金属部会シンポジウム〜ヒ素の毒性発現機序の解明に向けた挑戦〜 2022)
  • ヒ素による血管内皮細胞の機能障害を介した線溶活性の阻害機構
    (東京理科大学大学院 基礎衛生薬学特論(大学院講義) 2020)
  • ヒ素曝露による血管病変発症機構の探索
    (愛知学院大学第100回記念薬学セミナー 2019)
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Education (2)：
  • - 1999 1999, Tohoku University, Ph.D.
  • - 1992 Hokuriku University Faculty of Pharmaceutical Sciences 1992, Course of Pharmacy
Professional career (2)：
  • Ph. D. (Tohoku University)
  • B. Pharm. (Hokuriku University)
Work history (11)：
  • 2014/04 - 現在 Aichi Gakuin University School of Pharmacy Guest Researcher
  • 2014/04 - 現在 Tokyo University of Pharmacy and Life Sciences School of Pharmacy Professor
  • 2014/04 - 2017/03 Tokyo University of Science Research Institute for Science & Technology Guest Professor
  • 2013/01 - 2014/03 Tokyo University of Science Research Institute for Science & Technology Guest Associate Professor
  • 2007/04 - 2014/03 Aichi Gakuin University School of Pharmacy Associate Professor
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Committee career (53)：
  • 2024/07 - 現在 日本毒性学会 理事
  • 2024/07 - 現在 日本毒性学会 総務委員会 委員長
  • 2024/07 - 現在 日本毒性学会 総務委員会 名誉会員および功労会員選考委員会 委員長
  • 2022/07 - 現在 The Journal of Toxicological Sciences Deputy Editor-in-Chief
  • 2022/07 - 現在 日本毒性学会 編集委員会副委員長
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Awards (11)：
  • 2024/09 - 日本薬学会 環境・衛生部会 「学術賞」 有害金属の血管毒性発現機構に関する研究
  • 2022/07 - The Japanese Society of Toxicology Pfizer Highly Cited Paper Award 2022 Possible mechanisms underlying transcriptional induction of metallothionein isoforms by tris(pentafluorophenyl)stibane, tris(pentafluorophenyl)arsane, and tris(pentafluorophenyl)phosphane in cultured bovine aortic endothelial cells. J. Toxicol. Sci., 44(5), 327-333, 2019.
  • 2021/07 - The Japanese Society of Toxicology Pfizer Highly Cited Paper Award 2021 Photodynamic therapy using talaporfin sodium induces heme oxygenase-1 expression in rat malignant meningioma KMY-J cells. J. Toxicol. Sci., 43(5), 353-358, 2018.
  • 2020/06 - Tanabe Awards Methylmercury-induced neural degeneration in rat dorsal root ganglion is associated with the accumulation of microglia/macrophages and the proliferation of Schwann cells. J. Toxicol. Sci., 44(3), 191-199, 2019.
  • 2017/07 - The Japanese Society of Toxicology Pfizer Awards
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Association Membership(s) (4)：
日本毒性学会 ,  The Japan Atherosclerosis Society ,  The Japanese Society for Matrix Biology and Medicine ,  The Pharmaceutical Society of Japan
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