Rchr
J-GLOBAL ID：200901013512696042   Update date: Apr. 02, 2024

Konoki Keiichi

コノキ ケイイチ | Konoki Keiichi
Affiliation and department：
Tohoku University Graduate School of Agriculture Division of Bioscience and Biotechnology for Future Bioindustries Department of Applied Bioorganic Chemistry Laboratory of Bioorganic Chemistry of Natural Products

About Tohoku University Graduate School of Agriculture Division of Bioscience and Biotechnology for Future Bioindustries Department of Applied Bioorganic Chemistry Laboratory of Bioorganic Chemistry of Natural Products


Job title： Associate Professor
Homepage URL  (2)： https://www.agri.tohoku.ac.jp/bukka/index-j.html ,  https://www.agri.tohoku.ac.jp/bukka/English%20Version.htm
Research field  (3)： Bioorganic chemistry ,  Chemical biology ,  Molecular biochemistry
Research keywords  (4)： Electrophysiology ,  Voltage-gated sodium channels ,  Natural Product Chemistry ,  Target Identification
Research theme for competitive and other funds  (21)：
  • 2022 - 2025 マイトトキシンによる膜透過性亢進作用の完全解明
  • 2022 - 2023 新規下痢性貝毒定量法の確立
  • 2022 - 2023 下痢性貝毒の新規定量法の確立
  • 2019 - 2022 Design and synthesis of calcium ion regulatory molecules based on maitotoxin
  • 2017 - 2022 Dynamic conformation and domain structure of lipid molecules in model biomembranes
Show all
Papers (103)：
  • Mayu Hakamada, Chihiro Tokairin, Hayate Ishizuka, Kanna Adachi, Toma Osawa, Shiori Aonuma, Ryosuke Hirozumi, Shigeki Tsuchiya, Yuko Cho, Yuta Kudo, et al. Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis. Chemistry - A European Journal. 2024
  • Keita Yamaki, Kyoka Sato, Yuta Kudo, Yuko Cho, Keiichi Konoki, Tomohiro Takatani, Osamu Arakawa, Kentaro Kawatsu, Mari Yotsu-Yamsahita. The quite low cross-reactivity of Kawatsu's anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish. Toxicon. 2023. 107081-107081
  • Yuko Cho, Shigeki Tsuchiya, Takuo Omura, Kazuhiko Koike, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Metabolic inhibitor induces dynamic changes in saxitoxin biosynthesis and metabolism in the dinoflagellate Alexandrium pacificum (Group IV) under in vivo labeling condition. Harmful Algae. 2023. 122. 102372-102372
  • Osamu Chiba, Noriko Shimada, Shutaro Yoshio, Yuta Kudo, Yuko Cho, Mari Yotsu-Yamashita, Keiichi Konoki. State-Dependent Inhibition of Voltage-Gated Sodium Channels in Neuroblastoma Neuro-2A Cells by Arachidonic Acid from Halichondria okadai. Chemical Research in Toxicology. 2022. 35. 11. 1950-1961
  • Yuji Yaegashi, Yuta Kudo, Nozomi Ueyama, Ken-ichi Onodera, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita. Isolation and Biological Activity of 9-epiTetrodotoxin and Isolation of Tb-242B, Possible Biosynthetic Shunt Products of Tetrodotoxin from Pufferfish. Journal of Natural Products. 2022. 85. 9. 2199-2206
ｍore...
MISC (48)：
  • 渡邊龍一, 高柳優夏, 千葉修, 石塚颯, 小田木陽, 小澤眞由, 沼野聡, 内田肇, 松嶋良次, 此木敬一, et al. 無毒のサキシトキシン鏡像異性体標準物質の開発. 日本食品衛生学会学術講演会講演要旨集. 2023. 119th
  • 山下まり, 工藤雄大, 工藤雄大, 上山望, HANIFIN Charles T., 沼野聡, 長由扶子, 此木敬一. フグ毒テトロドトキシンの生合成経路の推定. 日本水産学会大会講演要旨集(CD-ROM). 2022. 2022
  • 沼野聡, 沼野聡, 工藤雄大, 工藤雄大, 長由扶子, 此木敬一, 山下まり. Screening for metabolites of paralytic shellfish toxins in the scallop, Patinopecten yessoensis. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
  • 梅野圭太郎, 尾上久晃, 此木敬一, 鳥飼浩平, 保野陽子, 大石徹. Synthetic Study of the W-F’ Ring Segment of Maitotoxin. 日本化学会春季年会講演予稿集(Web). 2021. 101st
  • 前野優香理, 小瀧裕一, 寺田竜太, 日高將文, 長由扶子, 此木敬一, 山下まり. 生合成酵素を用いたドウモイ酸類縁体の調製と構造活性相関. 日本農芸化学会東北支部大会プログラム・講演要旨集. 2021. 156th (CD-ROM)
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Patents (1)：
  • オカダ酸に結合する新規タンパク質、およびその遺伝子
Books (4)：
  • カキ・ホタテガイの科学
    朝倉書店 2019 ISBN:9784254485035
  • Clinical Neuroscience
    中外医学社 2017
  • Sorrel Organic Chemistry
    Tokyo Kagaku Dozin CO., LTD 2009
  • Marine Natural Product Chemistry
    Industrial Publishing & Consulting, Inc. 2008
Lectures and oral presentations  (226)：
  • アミノ酸輸送体阻害剤が渦鞭毛藻 STX 生合成に 及ぼす影響の動的解析
    (令和5年度 日本水産学会 春季大会 2023)
  • 致死性海藻中毒原因物質ポリカバノシド類の作用機序
    (令和5年度 日本水産学会 春季大会 2023)
  • サキシトキシンC11位第三級アルコール型誘導体の合成と電位依存性Naチャネル阻害活性評価
    (日本化学会第103春季年会 2023)
  • 海産毒マイトトキシンの脂質膜に対する影響
    (日本化学会第103春季年会 2023)
  • Synthetic study of a putative biosynthetic intermediate of paralytic shellfish toxin, saxitoxin
    (The 2023 Annual Meeting of The Japan Society for Bioscience, Biotechnology and Agrochemistry 2023)
ｍore...
Education (4)：
  • 1996 - 1997 The University of Tokyo Graduate School of Science Department of Chemistry
  • 1993 - 1996 The University of Tokyo Graduate School of Science Department of Chemistry
  • 1991 - 1993 The University of Tokyo Graduate School, Division of Science Department of Chemistry
  • 1987 - 1991 Waseda University Faculty of Science and Engineering Department of Chemistry
Professional career (2)：
  • 博士(理学) (The University of Tokyo)
  • 修士(理学) (The University of Tokyo)
Work history (5)：
  • 2008/04 - 現在 Graduate School of Agricultural Science, Tohoku University Associate Professor
  • 2006/07 - 2008/03 Department of Chemistry, Graduate School of Science, Osaka University Senior Scientist
  • 2003/07 - 2006/04 Department of Pharmacology, University of Washington Acting Instructor
  • 2000/07 - 2003/06 Department of Pharmacology, University of Washington Visiting Scientist
  • 1997/01 - 2000/06 Graduate School of Science, The University of Tokyo 助手
Committee career (16)：
  • 2021/03 - 2023/02 日本農芸化学会 英文誌編集委員会
  • 2020/03 - 2022/02 The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) Committee Member of The 2021 Annual Meeting of JSBBA
  • 2015/11 - 平成26年度日本農芸化学会特別シンポジウム 副支部長
  • 2015/11 - 第72回日本農芸化学会サイエンスカフェ・第47回農学カルチャー講座 世話人補佐
  • 2015/11 - 平成26年度日本農芸化学会特別シンポジウム 副支部長
Show all
Awards (4)：
  • 2023/02 - Japan Society for Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Mass spectrometry-guided discovery of new analogs of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity
  • 2022/02 - Bulletin of the Chemical Society of Japan BCSJ Award Article Convergent Synthesis of the WXYZA'B'C'D'E'F' Ring Segment of Maitotoxin
  • 2021/10 - The Tohoku Branch of The Japan Society for Bioscience, Biotechnology, and Agrochemistry The Best Student Presentation Award Elucidation of MTX-induced Membrane Blebbing
  • 2013/10/26 - 日本農芸化学会東北支部 平成25年度日本農芸化学会東北支部奨励賞 クロイソカイメンおよびホタテ貝による下痢性貝毒の蓄積機構
Association Membership(s) (2)：
Chemical Society of Japan ,  Japan Society for Bioscience, Biotechnology, and Agrochemistry
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