Konoki Keiichi

コノキケイイチ | Konoki Keiichi

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://www.agri.tohoku.ac.jp/bukka/index-j.html , https://www.agri.tohoku.ac.jp/bukka/English%20Version.htm

Research field (3)： Bioorganic chemistry , Chemical biology , Molecular biochemistry

Research keywords (4)： Electrophysiology , Voltage-gated sodium channels , Natural Product Chemistry , Target Identification

Research theme for competitive and other funds (23)：

2024 - 2027 ホタテガイ等の麻痺性貝毒検査における機器分析導入に向けた標準物質製造技術の開発
2023 - 2025 下痢性貝毒の新規定量法の確立
2022 - 2025 マイトトキシンによる膜透過性亢進作用の完全解明
2022 - 2023 新規下痢性貝毒定量法の確立
2022 - 2023 下痢性貝毒の新規定量法の確立

2019 - 2022 Design and synthesis of calcium ion regulatory molecules based on maitotoxin

2017 - 2022 Dynamic conformation and domain structure of lipid molecules in model biomembranes

2018 - 2021 テトロドトキシンのリスク管理のための研究

2017 - 2021 各種疾病治療を目指した電位依存性ナトリウムチャネルサブタイプ選択的阻害剤の探索

2020 - 2020 超活性天然物「マイトトキシン」の作用標的分子探索

2016 - 2019 Elucidation of mode-of-action of maitotoxin based on chemical synthesis

2015 - 2018 Molecular mechanisms of toxin synthesis in paralytic shellfish toxin producing dinoflagellates

2014 - 2017 Elucidation of biosynthetic pathways towards tetrodotoxin and saxitoxin based on the structures of novel biosynthetic intermediates

2014 - 2016 Preparation of the first antibody against carotenoids and elucidation of their target molecules in tissues and cells by visualization

2011 - 2016 Synthesis and functional analysis of ion channel selective inhibitors based on polycyclic ethers

2012 - 2016 Synthetic Studies of Maitotoxin to Elucidate Mode-of-Action

2011 - 2016 Control of ion-channel functions by analogues of natural toxins

2012 - 2015 Elucidation of mechanism for the non-toxic mutation of the paralytic shellfish toxin producing dinoflagellates by integrated omics analysis

2012 - 2015 Screening of an enzyme that transforms the diarrhetic shell fish poisoning toxins into 7-O-acylated derivative, from the Patinopecten yessoensis

2009 - 2012 Total Synthesis and Functional Analysis of Complex Natural Products

2009 - 2012 Self-resistance mechanism for secondary metabolite-accumulating species-Structure and function of okadaic acid-binding proteins

1998 - 2000 生体分子間相互作用解析装置を用いたオカダ酸結合タンパク質の同定

1998 - 2000 Molecular Mechanism of Action for Particularly Potent Marine Biotoxins.

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Papers (105)：

Yuko Cho, Shizu Hidema, Takuo Omura, Shigeki Tsuchiya, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Intracellular abundance, localization, and enzymatic activity of a saxitoxin biosynthesis enzyme, SxtG, in two sister subclones of the dinoflagellate Alexandrium catenella with extremely different levels of paralytic shellfish toxins. Harmful Algae. 2024. 139. 102723-102723
Masato Terauchi, Yuki Komazaki, Atsushi Yoshino, Yuko Cho, Yuta Kudo, Mari Yotsu-Yamashita, Keiichi Konoki. Assay for okadaic acid O-acyl transferase using HPLC-FLD. Bioscience, Biotechnology, and Biochemistry. 2024. 88. 9. 999-1006
Mayu Hakamada, Chihiro Tokairin, Hayate Ishizuka, Kanna Adachi, Toma Osawa, Shiori Aonuma, Ryosuke Hirozumi, Shigeki Tsuchiya, Yuko Cho, Yuta Kudo, et al. Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis. Chemistry - A European Journal. 2024
Keita Yamaki, Kyoka Sato, Yuta Kudo, Yuko Cho, Keiichi Konoki, Tomohiro Takatani, Osamu Arakawa, Kentaro Kawatsu, Mari Yotsu-Yamsahita. The quite low cross-reactivity of Kawatsu's anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish. Toxicon. 2023. 107081-107081
Yuko Cho, Shigeki Tsuchiya, Takuo Omura, Kazuhiko Koike, Keiichi Konoki, Yasukatsu Oshima, Mari Yotsu-Yamashita. Metabolic inhibitor induces dynamic changes in saxitoxin biosynthesis and metabolism in the dinoflagellate Alexandrium pacificum (Group IV) under in vivo labeling condition. Harmful Algae. 2023. 122. 102372-102372

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MISC (48)：

渡邊龍一, 高柳優夏, 千葉修, 石塚颯, 小田木陽, 小澤眞由, 沼野聡, 内田肇, 松嶋良次, 此木敬一, et al. 無毒のサキシトキシン鏡像異性体標準物質の開発. 日本食品衛生学会学術講演会講演要旨集. 2023. 119th
山下まり, 工藤雄大, 工藤雄大, 上山望, HANIFIN Charles T., 沼野聡, 長由扶子, 此木敬一. フグ毒テトロドトキシンの生合成経路の推定. 日本水産学会大会講演要旨集(CD-ROM). 2022. 2022
沼野聡, 沼野聡, 工藤雄大, 工藤雄大, 長由扶子, 此木敬一, 山下まり. Screening for metabolites of paralytic shellfish toxins in the scallop, Patinopecten yessoensis. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
梅野圭太郎, 尾上久晃, 此木敬一, 鳥飼浩平, 保野陽子, 大石徹. Synthetic Study of the W-F’ Ring Segment of Maitotoxin. 日本化学会春季年会講演予稿集(Web). 2021. 101st
前野優香理, 小瀧裕一, 寺田竜太, 日高將文, 長由扶子, 此木敬一, 山下まり. 生合成酵素を用いたドウモイ酸類縁体の調製と構造活性相関. 日本農芸化学会東北支部大会プログラム・講演要旨集. 2021. 156th (CD-ROM)

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Patents (1)：

オカダ酸に結合する新規タンパク質、およびその遺伝子

Books (7)：

第65回天然有機化合物討論会要旨集
2023
月刊海洋2023年1-2月号
海洋出版株式会社 2023
月刊海洋2023年1-2月号
海洋出版株式会社 2023
カキ・ホタテガイの科学
朝倉書店 2019 ISBN:9784254485035
Clinical Neuroscience
中外医学社 2017

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Lectures and oral presentations (238)：

Synthetic study of a putative biosynthetic intermediate of the paralytic shellfish toxin, saxitoxin
(International Symposium in Okinawa, 2023, on Ciguatera and Related Marine Biotoxins 2023)
Dynamic analysis of saxitoxin biosynthesis and catabolism in the dinoflagellate, Alexandrium catenella affected by nigericin
(International Symposium in Okinawa, 2023, on Ciguatera and Related Marine Biotoxins 2023)
Synthesis and identification of decarbamoyloxysaxitoxins in the toxic microalgae for elucidation of saxitoxin biosynthesis
(nternational Symposium in Okinawa, 2023, on Ciguatera and Related Marine Biotoxins 2023)
Colchicine induced dynamic changes in saxitoxin biosynthesis and metabolism in the dinoflagellate Alexandrium pacificum (Group IV)
(20th International Conference on Harmful Algae 2023)
MS-guided discovery of novel tricyclic guanidino compounds from tetrotodoxin-bearing newts and new analogues of antimalarial phosphotriester salinipostin from actinobacteria
(2023)

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Education (4)：

1996 - 1997 The University of Tokyo Graduate School of Science Department of Chemistry
1993 - 1996 The University of Tokyo Graduate School of Science Department of Chemistry
1991 - 1993 The University of Tokyo Graduate School, Division of Science Department of Chemistry
1987 - 1991 Waseda University Faculty of Science and Engineering Department of Chemistry

Professional career (2)：

博士(理学) (The University of Tokyo)
修士(理学) (The University of Tokyo)

Work history (5)：

2008/04 - 現在 Graduate School of Agricultural Science, Tohoku University Associate Professor
2006/07 - 2008/03 Department of Chemistry, Graduate School of Science, Osaka University Senior Scientist
2003/07 - 2006/04 Department of Pharmacology, University of Washington Acting Instructor
2000/07 - 2003/06 Department of Pharmacology, University of Washington Visiting Scientist
1997/01 - 2000/06 Graduate School of Science, The University of Tokyo 助手

Committee career (17)：

2023/07 - 2025/09 第67回天然有機化合物討論会実行委員
2021/03 - 2025/02 日本農芸化学会英文誌編集委員会
2020/03 - 2022/02 The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA) Committee Member of The 2021 Annual Meeting of JSBBA
2015/11 - 平成26年度日本農芸化学会特別シンポジウム副支部長
2015/11 - 第72回日本農芸化学会サイエンスカフェ・第47回農学カルチャー講座世話人補佐

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Awards (6)：

2023/12 - 日本農芸化学会東北支部学生優秀発表賞オカダ酸結合タンパク質OABP2.1を用いる簡易下痢性貝毒定量法の開発
2023/08 - Tohoku University GP-Chem Chemistry Summer School 2023 ポスター発表賞 Evaluation of inhibitory activities of synthetic saxitoxin derivatives to voltage-gated sodium channels
2023/02 - Japan Society for Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Mass spectrometry-guided discovery of new analogs of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity
2022/02 - Bulletin of the Chemical Society of Japan BCSJ Award Article Convergent Synthesis of the WXYZA'B'C'D'E'F' Ring Segment of Maitotoxin
2021/10 - The Tohoku Branch of The Japan Society for Bioscience, Biotechnology, and Agrochemistry The Best Student Presentation Award Elucidation of MTX-induced Membrane Blebbing

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Association Membership(s) (2)：

Chemical Society of Japan , Japan Society for Bioscience, Biotechnology, and Agrochemistry

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