Rchr

J-GLOBAL ID：200901013889095469 Update date: Oct. 31, 2024

Kioka Noriyuki

キオカノリユキ | Kioka Noriyuki

Affiliation and department：
Job title： Professor

Research field (3)： Applied molecular and cellular biology , Applied biochemistry , Cell biology

Research keywords (4)：細胞生物学 , 分子生物学 , Cell Biology , Molecular Biology

Research theme for competitive and other funds (33)：

2021 - 2025 細胞外基質による細胞機能制御機構の包括的理解とその応用基盤の研究
2019 - 2023 接着斑細胞膜は特殊な膜領域で細胞機能を調節するか?
2018 - 2021 Molecular mechanism of regulation of cellular functions by extracellular matrix stiffness
2016 - 2018 Approach to identify a novel mechanism which modulates vitaminA regulation of adipocyte differentiation
2014 - 2016 細胞外マトリックスの硬さによる上皮管腔組織形成の制御

2014 - 2016 Exploring a novel mechanism regulating differentiation into beige adipocytes

2012 - 2015 Analysis of molecular mechanim for sensing stiffness of extracellular matrix

2012 - 2014 Studies of factors that inhibit the macrophage migration

2008 - 2011 Functional analysis of focal adhesion proteins-sensors and re gulators for microenvironment

2005 - 2007 インテグリン裏打ち蛋白質とがん細胞の接着・運動制御

2004 - 2007 PhYsiological function of focal adiesion protein vinexin

2002 - 2004 細胞膜裏打ち蛋白質による足場依存的細胞増殖と浸潤の制御

2003 - 2003 ABC蛋白の多機能性と生命維持機構

2002 - 2003 Analysis of physiological function of a focal adhesion protein vinexin

2002 - 2003 Molecular mechanism of ATP-dependent transporters involved in cholesterol homeostasis

1998 - 2002 ABC蛋白の機能の多様性の分子基盤

2002 - インテグリン裏打ち蛋白質による細胞骨格と細胞運動の制御

2002 - Functions of focal adhesion proteins in regulating cytoskeleton and cell migration

2000 - 2001 細胞の増殖シグナル及び癌の浸潤転移における新規裏打蛋白質ビネキシンの機能解析

1999 - 2001 Comprehensive study on the regulation of metabolism of lipids including long-chain fatty acids and very-long-chain faty acids

1997 - 2000 Molecular design of anti-metastatic sugars from lipophilic anti-invasive sugar derivatives

1999 - 1999 裏打蛋白ビネキシンとSosの相互作用からみた細胞骨格とシグナル伝達のクロストーク

1997 - 1998 A novel signal transduction mechanism via intracellular ATP sensor

1994 - 1994 ラットN-アセチルグルコサミン転移酵素Iと酵母OCHIのゴルジ体局在化機構の解明

1993 - 1993 N-アセチルグルコサミン転移酵素I遺伝子の発現制御機構と機能の解析

1993 - 1993 P糖蛋白質の物質輸送およびチャネル活性とATP加水分解の共役

1993 - 1993 P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

1992 - 1993 Molecular mechanism of steroid transporter P-glycoprotein

1990 - 1993 Development and application of new regulatory genes

1992 - 1992 P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

シグナル伝達と細胞分化におけるインテグリン裏打ちタンパク質の機能解析

Functional Analysis of focal adhesion Proteins in signal transduction and cell differentiation

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Papers (135)：

Kazuki Sakata, Noriyuki Kioka, Kazumitsu Ueda, Yasuhisa Kimura. The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids. The Journal of Biochemistry. 2024
Hiroshi Tachibana, Kodai Minoura, Tomohiro Omachi, Kohjiro Nagao, Takafumi Ichikawa, Yasuhisa Kimura, Nozomu Kono, Yuta Shimanaka, Hiroyuki Arai, Kazumitsu Ueda, et al. The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains. Journal of cell science. 2023. 136. 16
Ryota Futamata, Masato Kinoshita, Katsueki Ogiwara, Noriyuki Kioka, Kazumitsu Ueda. Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a Japanese medaka (Oryzias latipes). Heliyon. 2023
Atsushi Kodan, Ryota Futamata, Yasuhisa Kimura, Noriyuki Kioka, Toru Nakatsu, Hiroaki Kato, Kazumitsu Ueda. ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs. FEBS letters. 2021. 595. 6. 707-716
Ryota Futamata, Noriyuki Kioka, Kazumitsu Ueda. Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein. Bio-protocol. 2021. 11. 4. e3930

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MISC (213)：

増元亮裕, 木村泰久, 木岡紀幸. A system for transient localization of lipid-modifying enzyme to focal adhesion using chemically induced dimerization. 日本細胞生物学会大会(Web). 2021. 73rd
立花大, 長尾耕治郎, 木村泰久, 木岡紀幸. FA membrane has a specific lipid composition. 日本細胞生物学会大会(Web). 2021. 73rd
鎌田一希, 木村泰久, 木岡紀幸. Purification of Focal Adhesion Protein, Vinexin α using Mammalian Cells. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
小笠原史彦, 岡本雄介, 木村泰久, 木岡紀幸, 木岡紀幸, 植田和光. C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
増元亮裕, 木村泰久, 木岡紀幸. A system for transient PIP5K localization to focal adhesion using chemically induced dimerization. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

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Books (1)：

糖転移酵素遺伝子の単離と解析
遺伝子の構造と機能//学会出版センター,/,173 1998

Lectures and oral presentations (7)：

膜領域としての細胞接着斑細胞膜
(第91回日本生化学会大会シンポジウム 2018)
Vinculin and SORBS (vinexin) family proteins in mechanosensing and mechanotransduction
(3rd International Symposium on Mechanobiology 2017)
ECM stiffness-dependent differentiation into adipocytes involves vinculin regulation of YAP/TAZ
(ConBio2017 2017)
ビネキシンαの両親媒性ヘリックスはテーリンと協調的にビンキュリンと相互作用する
(日本細胞生物学会大会講演要旨集 2016)
接着斑タンパク質ビネキシンαの両親媒性へリックスはビンキュリンの構造変化を引き起こすために必要である
(日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015)

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Works (2)：

ビネキシンによるJNK/SAPKの制御
1999 -
Regulation ob JNK/SAPK activation by vinexin
1999 -

Education (4)：

- 1991 Kyoto University
- 1991 Kyoto University Graduate School, Division of Agriculture
- 1986 Kyoto University Faculty of Agriculture
- 1986 Kyoto University Faculty of Agriculture

Professional career (1)：

Doctor of Agriculture

Work history (5)：

2019/04 - 現在京都大学大学院農学研究科教授
2007/04 - 2019/03 京都大学大学院農学研究科准教授
2003/07 - 2007/03 京都大学大学院農学研究科助教授
1991/04 - 2003/06 Kyoto University
1994/07 - 1996/07 NIDR, NIH, USA

Awards (6)：

2022/04 - 長瀬科学技術振興財団長瀬研究振興賞
2020 - Bioscience, Biotechnology, and Biochemistry 論文賞
2019 - Bioscience, Biotechnology, and Biochemistry 論文賞
2017 - Bioscience, Biotechnology, and Biochemistry 論文賞
2003 - 日本農芸化学会農芸化学奨励賞

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Association Membership(s) (3)：

細胞生物学会 , 生化学会 , 農芸化学会

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