Rchr

J-GLOBAL ID：200901013920492498 Update date: Nov. 20, 2024

Hida Kyoko

ヒダキヨウコ | Hida Kyoko

Affiliation and department：
Job title：教授
Homepage URL (2)： https://www.den.hokudai.ac.jp/vascular-biol-pathol/ , http://www.den.hokudai.ac.jp/vascular-biology/

Research field (3)： Surgical dentistry , Experimental pathology , Pathobiochemistry

Research keywords (6)：腫瘍学 , 血管新生 , 細胞生物学 , angiogenesis , Cell Biology , Oncology

Research theme for competitive and other funds (51)：

2023 - 2025 A drug development study for radiation osteonecrosis of jaw with improving micro vascular-skeletal structure
2022 - 2025 Development of new diagnostic method of bladder cancer based on mRNA derived from urine exosome
2022 - 2024 がんと感染症に共通した血栓形成機序の解明
2021 - 2024 がんと腫瘍血管の相互作用による新たな転移促進機構の解明とその制御
2021 - 2024 腫瘍血管トランスポーターを標的とした薬剤耐性口腔がんの制御

2021 - 2024 Development of new anti-cancer strategy via activation of immunity by targeting tumor endothelial factors

2021 - 2024 腫瘍特異的血管新生阻害剤とドラッグリポジショニングによる新規肺癌治療の開発

2020 - 2023 Development of oncolytic virus targeting tumor angiogenesis factor

2022 - 2023 血管の制御による重症化COVID-19治療薬の開発

2019 - 2022 Exploratory research of innovative pulp capping materials both with promoting healing of dental pulp and adhesive property to hard tissue

2019 - 2022 エナメル上皮腫の浸潤機構解明による新規治療法の開発

2019 - 2022 Association between oral bacteria and oral cancer metastasis

2021 - 2022 COVID-19重症化における血管内皮細胞の感染病態解明と治療法の開発

2018 - 2021 high-throughput screening for tumor endothelial cell specific inhibitors

2018 - 2021 Elucidation of the mechanism for cancer metastasis induced by oral cancer exosome and development of novel therapy for metastatic cancer

2018 - 2021 Basic research for elucidation of the mechanisms of tumor metastasis by tumor endothelial cells

2018 - 2021 腫瘍血管・がん微小環境のネットワークの解明と新規血管新生阻害療法の開発

2018 - 2020 細胞社会をつなぐ血管内皮細胞のダイバーシティー獲得機構の解明

2012 - 2016 Development of the drugs targeting lung tumor endothelial cells and the companion diagnosis

2012 - 2015 Development of novel therapy targeting cancer stem cells by ROS regulation

2012 - 2015 Development of the treatment that targeted an arachidonate cascade of the oral cancer neighborhood environment

2012 - 2014 Investigation of the mechanism of enhanced lung metastasis due to exosome from tumor endothelial cells

2012 - 2014 口腔環境が口腔がんの悪性化・上皮間葉移行を誘導する機構の解明

2009 - 2014 血管を標的とする革新的医薬分子送達法の基盤技術の確立

2011 - 2013 腫瘍血管と微小環境との相互作用の解明とその分子機構を標的とした治療法開発

2011 - 2013 Discovery of diagonositc and therapeutic biomarker by circulating tumor endothelial cells in metastatic renal cell carcinoma

2011 - 2013 Development of novel therapies by antioxidants for reactive oxidative species of tumor microenvironment in oral carcinoma

2012 - 2012 非小細胞肺癌幹細胞における分泌型miRNAの同定とその治療応用へ向けての解析

2011 - 2012 Novel oncogenic mechanism of oral cancer mediated by HPV

2011 - 2012 Targeting tumor metastasis by normalization of tumor blood vessels

2009 - 2012 Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy

2010 - 2011 Basic research for oral cancer diagnosis estimated by HuR export

2009 - 2011 Mechanism of premetastatic niche formation and promotion of metastasis by cancer mesenchymal cells

2009 - 2011 Export of RNA-protein complex and oncogenesis

2009 - 2011 Application of EPC for tissue regeneration

2008 - 2011 Exploitation of gene-targeting therapy based on the cellular and biological features of oral-carcinoma stem cell and tumor microenvironment.

2009 - 2010 血管新生阻害療法に対する腫瘍血管内皮細胞の抵抗性獲得の機序解析

2008 - 2010 Basic research for cancer therapy by knockdown of RNA binding protein

2008 - 2010 Development of novel antiangiogenic therapy based on tumor microenviroenment

2008 - 2010 Development of new screening system for anti-angiogenic drugs using tumor associated endothelial cells derived from renal cell carcinoma

2007 - 2009 Detection of cervical lymphnode micrometastasis in oral cancer

2007 - 2008 口腔がんの顎骨浸潤は抑制できるか?-EGFレセプターリン酸化阻害による効果-

2007 - 2008 口腔白板症の悪性化に関わる因子は何か?-HuRと細胞質移行タンパクの解析-

2007 - 2008 RNA結合タンパクの局在と口腔がんの悪性度

2006 - 2007 Export and stabilization of AU-rich element containng mRNA in oral cancer cells

2006 - 2007 Gene Targeting Therapy against tumor endothelial cells

2006 - 2007 Development of gene delivery system using nanocoloid and its application for gene targeting therapy

2006 - 2007 The significance of endothelial progenitor cell as a tumor marker in PBMC

2006 - 2007 Analysis of Tumor-associated Endothelial Cell Biology

2004 - study of tumor-associated endothelial cell specific markersbiology of tumor-associated endothelial cells biology of endothelial projenitor cells (EPC)

1998 - 1999 口腔がんにおける浸潤・転移の機構解明- 転写因子EIAFの機能分析-

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Papers (131)：

Baba S., Kawasaki T., Hirano S., Nakamura T., Asano T., Okazaki R., Yoshida K., Kawase T., Kurahara H., Oi H., et al. A noninvasive urinary microRNA-based assay for the detection of pancreatic cancer from early to late stages: a case control study. 2024
Ji-Won Lee, Kaito Mizuno, Haruhisa Watanabe, In-Hee Lee, Takuya Tsumita, Kyoko Hida, Yasutaka Yawaka, Yoshimasa Kitagawa, Akira Hasebe, Tadahiro Iimura, et al. Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model. Journal of Neuroinflammation. 2024. 21. 1
Miho Tokumasu, Mikako Nishida, Weiyang Zhao, Ruoyu Chao, Natsumi Imano, Nahoko Yamashita, Kyoko Hida, Hisamichi Naitoc, Heiichiro Udono. Metformin synergizes with PD-1 blockade to promote normalization of tumor vessels via CD8T cells and IFNγ. PNAS. 2024. e2404778121
武田叡司, 格口渉, 高橋賢多, 栗林和代, 松田彩, 間石奈湖, 樋田京子, 足利雄一, 大廣洋一. 初診時から舌リンパ節に転移を認めた口底癌の1例. 日本口腔科学会雑誌. 2024. 73. 1. 34-34
桜井優弥, 間石奈湖, 藤岡容一郎, 大場雄介, 武田遼, 佐々木道仁, 大場靖子, 樋田泰浩, 澤洋文, 樋田京子. 血管内皮細胞におけるSARS-CoV-2侵入機構の解析(Analysis of SARS-CoV-2 uptake mechanism in vascular endothelial cells). 日本病理学会会誌. 2024. 113. 1. 369-369

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MISC (164)：

Yoshinobu Takakura, Rikinari Hanayama, Kazunari Akiyoshi, Shiroh Futaki, Kyoko Hida, Takanori Ichiki, Akiko Ishii-Watabe, Masahiko Kuroda, Kazushige Maki, Yasuo Miura, et al. Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles. Pharmaceutical Research. 2024
Li Yu, Nako Maishi, Aya Matsuda, Kyoko Hida. The functional network of biglycan: A new frontier in tumor progression. Proteoglycan Research. 2023. 1. 3
Haruhisa Watanabe, Nako Maishi, Marie Hoshi-Numahata, Mai Nishiura, Atsuko Nakanishi-Kimura, Kyoko Hida, Tadahiro Iimura. Skeletal-Vascular Interactions in Bone Development, Homeostasis, and Pathological Destruction. International Journal of Molecular Sciences. 2023. 24. 13. 10912-10912
Kyoko Hida, Nako Maishi, Aya Matsuda, Li Yu. Beyond starving cancer: anti-angiogenic therapy. Journal of Medical Ultrasonics. 2023
桜井優弥, 間石奈湖, 藤岡容一朗, 大場雄介, 武田遼, 佐々木道仁, 大場靖子, 樋田泰浩, 澤洋文, 澤洋文, et al. 血管内皮細胞におけるSARS-CoV-2侵入機構の解析. 日本血管生物医学会学術集会プログラム・抄録集. 2023. 31st (CD-ROM)

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Books (17)：

血管内被細胞が制御するがんの進展
医歯薬出版株式会社 2024
新臨床腫瘍学( 改訂第7版)ーがんの発生と進展機構ー
南江堂 2024
染色体・遺伝子の基本
医歯薬出版 2024
The Roles of Tumor Endothelial Cells in Cancer Metastasis
Exon Publications 2022 ISBN:9780645332025
新臨床腫瘍学(改訂第6版)-がん薬物療法専門医のために-
南江堂 2021

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Lectures and oral presentations (230)：

がん関連血栓症における腫瘍血管内皮細胞の役割の解明
(第66回歯科基礎医学会学術大会歯科基礎医学会ライオン学術賞受賞講演 2024)
高転移性腫瘍エクソソームによる血管内皮の異常性獲得
(第66回歯科基礎医学会学術大会アップデートシンポジウム5 2024)
Tumor endothelial cells and cancer-associated thrombosis
(2024)
The role of tumor endothelial cells in cancer metastasis
(2024 KSBC-Hokkaido University Joint Symposium on Bioconvergence 2024)
がんから感染症まで:腫瘍血管研究が導く新たな発見
(2024)

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Education (4)：

1995 - 1998 Hokkaido University Graduate School of Dental Medicine
- 1998 Hokkaido University Graduate School, Division of Dental Research PhD
1986 - 1992 Hokkaido University School of Dental Medicine
- 1992 Hokkaido University Faculty of Dentistry

Professional career (1)：

1998 PhD (Hokkaido Univ. Dental School) (Hokkaido University)

Work history (18)：

2018/05 - 現在 Hokkaido University Vascular Biology and Molecular Pathology,Graduate School of Dental Medicine rofessor
2014/04 - 2018/04 Hokkaido University Institute for Genetic Medicine
2009/04 - 2014/03 北海道大学大学院歯学研究科口腔病態学講座血管生物学教室・特任准教授
2007/04 - 2009/03 北海道大学大学院歯学研究科口腔病態学講座口腔病理病態学・助教
2005/04 - 2007/03 Hokkaido University Graduate School of Dental Medicine

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Committee career (21)：

2022/12 - 現在第42回日本口腔腫瘍学会総会・学術大会企画委員
2021/05 - 現在独立行政法人医薬品医療機器総合機構科学委員会エクソソームを含む細胞外小胞(EV)を利用した治療用製剤に関する専門部会委員
2020/06 - 現在歯科基礎医学会企画委員
2020 - 現在日本がん転移学会理事
2019 - 現在国立研究開発法人新エネルギー・産業技術総合開発機構(NEDO) 分野横断的公募事業に係る事前書面審査員(ピアレビュア)

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Awards (8)：

2024/05 - 歯科基礎医学会第24回歯科基礎医学会ライオン学術賞がん関連血栓症における腫瘍血管内皮細胞の役割の解明
2023/10 - 国立大学法人北海道大学令和5年度国立大学法人北海道大学桂田芳枝賞
2018/05 - 資生堂第11回資生堂女性研究者サイエンスグラント高転移性腫瘍細胞外小胞由来miRNAは腫瘍血管内皮における薬剤耐性を誘導する
2017/03 - The Society of Japanese Women Scientists The Society of Japanese Women Scientists Encouragement Prize
2012/12 - The 10th Korea-Japan Joint Symposium on Vascular Biology The 20th annual Meeting of the Japanese Vascular Biology and MedicineOrganization, Characterization of stem-like tumor endothelial cells

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Association Membership(s) (19)：

Council Member Science council Japan , Science council Japan , 日本がん免疫学会 , 日本臨床口腔病理学会 , 日本細胞外小胞学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE SOCIETY OF JAPANESE WOMEN SCIENTISTS , 日本がん転移学会 , JAPAN SOCIETY FOR CELL BIOLOGY , 歯科基礎医学会 , JAPANESE SOCIETY OF ORAL AND MAXILLOFACIAL SURGEONS , JAPANESE STOMATOLOGICAL SOCIETY , THE JAPANESE CANCER ASSOCIATION , アメリカ癌学会 , 日本血管生物医学会 , THE JAPANESE SOCIETY OF PATHOLOGY , Japanese Association of PathologyJapanese association of Pathology , American Association of cancer research , 北海道歯学会

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