Rchr
J-GLOBAL ID：200901014525771465   Update date: Nov. 16, 2024

Ohno Shigeo

オオノ シゲオ | Ohno Shigeo
Affiliation and department：
Juntendo University Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine

About Juntendo University Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine


Job title： Special Contract Professor
Other affiliations (1)：
  • Yokohama City University  Professor
Homepage URL  (1)： http://www-user.yokohama-cu.ac.jp/~ohnos//Japanease/indexJ.html
Research field  (7)： Functional biochemistry ,  Experimental pathology ,  Pathobiochemistry ,  Medical biochemistry ,  Developmental biology ,  Cell biology ,  Molecular biology
Research keywords  (29)： Epithelium ,  Adherens Junction ,  Tight Junction ,  cell adhesion ,  RNA ヘリカーゼ ,  リン脂質キナーゼ ,  プロテインキナーゼ ,  mRNA サーベイランス ,  ナンセンス変異 ,  極性 ,  非対称分裂 ,  線虫 ,  PAR-6 ,  PAR-3 ,  ASIP ,  aPKC ,  RNA helicase ,  PIK related protein kinase ,  protein kinase ,  mRNA surveillance ,  mRNA degradation ,  nonsense mutation ,  polarity ,  asymmetric division ,  C. elegans ,  PAR-6 ,  PAR-3 ,  ASIP ,  aPKC
Research theme for competitive and other funds  (54)：
  • 2016 - 2019 Analysis of molecular mechanism of pathogenesis from disturbance of cell polarity caused by oxidative stress response
  • 2012 - 2016 Identification of the molecular target to regulate Cell Polarity during 3 dimensional morphogenesis.
  • 2011 - 2016 Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
  • 2011 - 2016 Regulation of cell polarity and cell fates in tissue stem/progenitor cells
  • 2012 - 2015 Mechanism for the maintenance of skin stem cells by a cell polarity protein
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Papers (341)：
  • Matsuoka I, Kasai T, Onaga C, Ozaki A, Motomura H, Maemura Y, Tada Y, Mori H, Hara Y, Xiong Y, et al. Co-expression of SLC20A1 and ALDH1A3 is associated with poor prognosis, and SLC20A1 is required for the survival of ALDH1-positive pancreatic cancer stem cells. Oncology Letters. 2024. 28. 3. 426
  • Teppei Sunaguchi, Yosuke Horikoshi, Takehiko Hanaki, Teruhisa Sakamoto, Kazuhiro Nakaso, Chieko Sakai, Kazunari Yamashita, Shigeo Ohno, Yoshiyuki Fujiwara, Tatsuya Matsura. High Glucose-stimulated aPKC Activation Promotes Pancreatic Cancer Cell Progression Through YAP Signaling. Anticancer research. 2023. 43. 11. 4843-4853
  • Mario A Shields, Anastasia E Metropulos, Christina Spaulding, Tomonori Hirose, Shigeo Ohno, Thao N D Pham, Hidayatullah G Munshi. BET inhibition rescues ciliogenesis and ameliorates pancreatitis-driven phenotypic changes in mice with Par3 loss. bioRxiv : the preprint server for biology. 2023
  • Takahiro Kasai, Shoma Tamori, Yuta Takasaki, Izumi Matsuoka, Ayaka Ozaki, Chika Matsuda, Yohsuke Harada, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto. High expression of PKCλ and ALDH1A3 indicates a poor prognosis, and PKCλ is required for the asymmetric cell division of ALDH1A3-positive cancer stem cells in PDAC. Biochemical and biophysical research communications. 2023. 669. 85-94
  • Taiki Okamoto, Chotaro Onaga, Izumi Matsuoka, Ayaka Ozaki, Chika Matsuda, Takahiro Kasai, Yuyun Xiong, Yohsuke Harada, Tsugumichi Sato, Yoshio Nakano, et al. High SLC20A1 Expression Indicates Poor Prognosis in Prostate Cancer. Cancer diagnosis & prognosis. 2023. 3. 4. 439-448
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MISC (152)：
  • Hitomi Shiina, Ayaka Ozaki, Shoma Tamori, Yuka Nozaki, Ryoko Takasawa, Kazunori Sasaki, Hitoshi Isiguro, Yohei Miyagi, Yoji Nagashima, Sei-ichi Tanuma, et al. Correlation between Glyoxalase 1 and PKC lambda is predictive of poor clinical outcomes in late-stage breast cancer. CANCER SCIENCE. 2021. 112. 825-825
  • 本村瞳, 尾崎綾栞, 多森翔馬, 翁長朝太郎, 野崎優香, 和氣由布子, 高澤涼子, 吉澤一巳, 真野泰成, 佐藤嗣道, et al. Correlation between Glyoxalase 1 and Protein kinase C λis predictive of poor clinical outcomes in late-stage breast cancer. 日本薬学会年会要旨集(Web). 2021. 141st
  • 廣瀬智威, 廣瀬智威, 杉谷善信, 杉谷善信, 栗原秀剛, 栗原秀剛, 風間宏美, 日下智保, 野田哲生, 野田哲生, et al. PAR3 Restricts the Expansion of Neural Precursor Cells by Regulating Hedgehog Signaling. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
  • 本村瞳, 尾崎綾栞, 多森翔馬, 野崎優香, 高澤涼子, 佐々木和教, 石黒斉, 宮城洋平, 長嶋洋治, 田沼靖一, et al. Correlation between GLO1 and PKCλ contributes to prediction for poor clinical outcome at late stage of breast cancer. 日本癌学会学術総会抄録集(Web). 2019. 78th
  • Tamura-Furukawa Kana, Yamashita Kazunari, Ohno Shigeo. FETAL AND MATERNAL ASYMMETRY IN PLASMA MEMBRANE DOMAINS OF SYNCYTIOTROPHOBLAST LAYER-I CELLS ARE MAINTAINED BY A POLARITY-REGULATING FACTOR, KIBRA-LIKE/WWC2. FETAL AND MATERNAL ASYMMETRY IN PLASMA MEMBRANE DOMAINS OF SYNCYTIOTROPHOBLAST LAYER-I CELLS ARE. PLACENTA. 2018. 69. E90
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Books (4)：
  • 翻訳後修飾のプロテオミクス : 質量分析装置を中心とした分析法の原理
    講談社 2011 ISBN:9784061538849
  • シグナル伝達 : 細胞運命と細胞機能を制御する仕組み
    共立出版 2001 ISBN:4320055608
  • タンパク実験プロトコール 1 : 機能解析編
    秀潤社 1997 ISBN:4879621714
  • タンパク実験プロトコール 2 : 構造解析編
    秀潤社 ISBN:4879621781
Lectures and oral presentations  (35)：
  • ASPP2 regulates epithelial cell polarity through the PAR complex.
    (The 50th American Society for Cell Biology Annual Meeting 2010)
  • Signaling Crosstalk between Cell Polarity and Cell Growth/Apoptosis.
    (第33回日本分子生物学会年会 第83回日本生化学会大会 合同大会 2010)
  • Inside-out signalling effects on extracellular membrane and polarity.
    (The 8th International Podocyte Conference 2010)
  • ASPP2 regulates epithelial cell polarity through the PAR complex.
    (2010)
  • Signaling Crosstalk between Cell Polarity and Cell Growth/Apoptosis.
    (2010)
ｍore...
Education (4)：
  • - 1980 The University of Tokyo
  • - 1980 The University of Tokyo Graduate School, Division of Natural Science
  • - 1975 The University of Tokyo College of Arts and Sciences Department of Basic Science
  • - 1975 The University of Tokyo Faculty of Liberal Arts
Professional career (1)：
  • 理学博士 (東京大学)
Work history (4)：
  • 2020/10 - 現在 Juntendo University Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine Special Contract Professor
  • 1991/05 - 現在 Yokohama City University School of Medicine Molecular Biology Professor
  • 1983/04 - 1991/04 Tokyo Metropolitan Institute of Medical Science Molecular Biology Research Scientist
  • 1980/04 - 1983/03 癌研究会癌研究所 生化学部 嘱託研究員
Committee career (25)：
  • Tissue and Barrier 編集委員
  • J. Biochemistry誌 部門編集長
  • J. Biochemistry誌 編集委員
  • 日本女性科学者の会 顧問
  • 生物科学学会連合 委員
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Awards (3)：
  • 2002 - 木原記念財団学術賞
  • 1991 - 日本癌学会奨励賞
  • 1989 - 日本生化学会奨励賞(PKCの構造と酵素学的多様性の発見)
Association Membership(s) (4)：
THE JAPANESE CANCER ASSOCIATION ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  日本生化学会 ,  The Japanease Biochemical Society
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