Kimura Tetsunari

キムラテツナリ | Kimura Tetsunari

Affiliation and department：
Job title： Associate Professor

Research field (3)： Biophysics , Biochemistry , Basic physical chemistry

Research keywords (1)：蛋白質のダイナミクス

Research theme for competitive and other funds (11)：

2022 - 2025 時間分解測定法によるABCトランスポーター膜輸送機構の化学的解明
2021 - 2024 病原菌ヘムトランスポーターの構造変化の追跡と基質輸送機構の解明
2019 - 2024 時間分解構造解析を補完する精密顕微分光計測
2017 - 2019 タンパク質ダイナミクス観測に資する高時空間分解能ESR・IR計測系の開発と応用
2016 - 2019 ヒト癌抑制遺伝子候補101F6によるレドックス擾乱細胞死誘導機構の解明

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Papers (55)：

Hanae Takeda, Kanji Shimba, Masaki Horitani, Tetsunari Kimura, Takashi Nomura, Minoru Kubo, Yoshitsugu Shiro, Takehiko Tosha. Trapping of a Mononitrosyl Nonheme Intermediate of Nitric Oxide Reductase by Cryo-Photolysis of Caged Nitric Oxide. The journal of physical chemistry. B. 2023. 127. 4. 846-854
Takashi Nomura, Tetsunari Kimura, Yusuke Kanematsu, Daichi Yamada, Keitaro Yamashita, Kunio Hirata, Go Ueno, Hironori Murakami, Tamao Hisano, Raika Yamagiwa, et al. Short-lived intermediate in N2O generation by P450 NO reductase captured by time-resolved IR spectroscopy and XFEL crystallography. Proceedings of the National Academy of Sciences. 2021. 118. 21. e2101481118-e2101481118
Hongjie Li, Yoshiki Nakajima, Takashi Nomura, Michihiro Sugahara, Shinichiro Yonekura, Siu Kit Chan, Takanori Nakane, Takahiro Yamane, Yasufumi Umena, Mamoru Suzuki, et al. Capturing structural changes of the S1 to S2 transition of photosystem II using time-resolved serial femtosecond crystallography. IUCrJ. 2021. 8. Pt 3. 431-443
Kazumasa Oda, Takashi Nomura, Takanori Nakane, Keitaro Yamashita, Keiichi Inoue, Shota Ito, Johannes Vierock, Kunio Hirata, Andrés D Maturana, Kota Katayama, et al. Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin. eLife. 2021. 10
Aliaa M Radwan, Eman F Aboelfetoh, Tetsunari Kimura, Tarek M Mohamed, Mai M El-Keiy. Role of Zinc Oxide Nanoparticles Synthesized by Fenugreek Seeds Extract as Anticancer Agent: In Vitro and In Vivo Studies. Anti-cancer agents in medicinal chemistry. 2021

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MISC (10)：

南後恵理子, 南後恵理子, LUO Fangjia, LUO Fangjia, 木村哲就, 菅原道泰, 中根崇智, 鈴木守, 桝田哲哉, 溝端栄一, et al. 二液混合シリアルフェムト秒結晶構造解析による酵素反応追跡. 日本結晶学会年会講演要旨集. 2021. 2021
Tetsunari Kimura, Hanae Takeda, Shoko Ishii, Takehiko Tosha, Yoshitsugu Shiro, Minoru Kubo. Molecular Mechanism of the Catalytic Reaction of no Reductase Revealed by Novel Time-Resolved Visible/IR Absorption Spectrometers with Microfluidic Device. BIOPHYSICAL JOURNAL. 2016. 110. 3. 548A-548A
田中智之, 菅原道泰, 中根崇智, 木村哲就, 木村哲就, 久保稔, 久保稔, 宮島謙, 宮島謙, 登野健介, et al. SACLAにおけるシリアルフェムト秒X線結晶構造解析の技術開発. 日本結晶学会年会講演要旨集. 2016. 2016
南後恵理子, NEUTZE Richard, 久保稔, 久保稔, 木村哲就, 中根崇智, ROYANT Antoine, 登野健介, 岩田想. 時分割シリアルフェムト秒X線結晶解析法によるバクテリオロドプシン光反応中間体の構造解析. 日本結晶学会年会講演要旨集. 2015. 2015
古谷祐詞, 木村哲就, 岡本基土. 急速緩衝液交換法による時間分解全反射赤外分光法の開発. 生物物理. 2014. 54. 5. 272-275

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Lectures and oral presentations (77)：

マイクロ流路デバイスを用いた時間分解顕微分光法による膜輸送の分子機構解析
(2022)
膜輸送タンパク質 ABC トランスポーターの機能・構造変化の分光学的解析
(2022)
Developments and applications of time-resolved microspectroscopy for protein micro-crystals
(PacifiChem2021 2021)
Structural changes of a-synuclein, an intrinsically disordered protein, along the lipid-binding and oligomerization revealed by fluorescence lifetime measurements
(PacifiChem2021 2021)
Transmembrane electron-transfer reaction of 101F6 protein reconstituted into nanodisc
(PacifiChem2021 2021)

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Education (3)：

- 2005 京都大学大学院工学研究科博士後期課程分子工学専攻修了
- 2002 Kyoto University
- 2000 Kyoto University Faculty of Engineering School of Industrial Chemistry

Professional career (2)：

修士(工学) (京都大学)
博士(工学) (京都大学)

Work history (1)：

Kyoto University Graduate School of Engineering, Department of Molecular Engineering

Awards (2)：

2018/10 - International Congress on Pure and Applied Chemistry Langkawi 2018 Plenary Lecture Award(International Congress on Pure and Applied Chemistry Langkawi 2018) Membrane proteins in action; Structural and functional dynamics revealed by time-resolved measurements.
2015/06 - Protein Science Society of Japan 蛋白質科学会若手奨励賞マイクロ流体フローを用いた一酸化窒素還元酵素の触媒反応の動的分光観察

Association Membership(s) (4)：

Protein Science Society of Japan , 生物物理学会(Biophysical Society, U.S.A.) , 日本生物物理学会 , 日本化学会

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