Rchr
J-GLOBAL ID:200901014800820498   Update date: Mar. 16, 2024

Sakai Eiko

サカイ エイコ | Sakai Eiko
Affiliation and department:
Job title: Assistant Professor
Research field  (1): Oral medicine
Research keywords  (4): Dental pharmacology ,  membrane traffic ,  oxidative stress ,  osteoclast
Research theme for competitive and other funds  (59):
  • 2023 - 2026 Functional analysis of a novel membrane transport factor in metabolic bone diseases
  • 2023 - 2026 変異型Rufy4を発現する破骨細胞の細胞外小胞を介した骨吸収調節機構の解明と応用
  • 2020 - 2023 Functional and pathological analyses of inflammatory bone destruction disease by a novel Rab protein
  • 2020 - 2023 a novel therapeutic agent for osteoporosis having both antioxidant activity and PDE inhibitory activity
  • 2019 - 2022 Identification and functional elucidation of a novel transport factor in osteoclasts
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Papers (85):
  • 小柳 悠, 坂井 詠子, 山口 優, ファルハナ・ファティマ, 山田 志津香, 介田 圭, 江越 貴文, 平 曜輔, 村田 比呂司, 筑波 隆幸. Dennd2cは破骨細胞分化を負に制御する. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-271]
  • Ayuko Tanimoto, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Shun Oyakawa, Yusuke Ono, Noriaki Yoshida, Takayuki Tsukuba. Rab44 negatively regulates myoblast differentiation by controlling fusogenic protein transport and mTORC1 signaling. Journal of cellular biochemistry. 2023
  • Shun Oyakawa, Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Ayuko Tanimoto, Yusuke Ono, Hiroshi Murata, Takayuki Tsukuba. Rab44 deficiency accelerates recovery from muscle damage by regulating mTORC1 signaling and transport of fusogenic regulators. Journal of cellular physiology. 2023
  • Fatima Farhana, Eiko Sakai, Yu Koyanagi, Yu Yamaguchi, Mohammad Ibtehaz Alam, Kuniaki Okamoto, Takayuki Tsukuba. Abr, a Rho-regulating protein, modulates osteoclastogenesis by enhancing lamellipodia formation by interacting with poly(ADP-ribose) glycohydrolase. Molecular biology reports. 2023
  • 谷本 あゆ子, 山口 優, 門脇 知子, 親川 駿, 坂井 詠子, 小野 悠介, 吉田 教明, 筑波 隆幸. 高分子量Rabタンパク質が制御する筋芽細胞から筋管への分化機構. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1P-171
more...
MISC (51):
  • Sakai Eiko, Sato Mari, Sato Chikara. Commentary: Liquid-phase ASEM imaging of cellular and structural details in cartilage and bone formed during endochondral ossification: Keap1-deficient osteomalacia. J Orthopedics & Orthopedic Surg. 2022. 3. 3. 4-6
  • Eiko Sakai, Mari Sato, Nassirhadjy Memtily, Takayuki Tsukuba, Chikara Sato. Liquid-phase imaging of bone development and calcification by atmospheric scanning electron microscopy (ASEM): Application to immuno-labeling and rapid tissue observation of genetically modified mouse. Microscopy and Microanalysis. 2021. 27. S1. 2288-2289
  • 佐藤主税, MEMTILY Nassirhadjy, 佐藤真理, 笠畑尚喜, 坂井詠子. 大気圧走査電子顕微鏡ASEMによる骨細胞と軟骨の観察. 日本骨形態計測学会雑誌. 2021. 31. 2
  • 佐藤 主税, 坂井 詠子, 佐藤 真理, 笠畑 尚喜, 越野 雅至. 【バイオマテリアル研究に役立つ分析技術・評価法】クライオ透過電顕と大気圧走査電顕 親水環境での生物試料・骨組織代謝と無機結晶成長の観察. バイオマテリアル-生体材料-. 2019. 37. 4. 252-257
  • 佐藤 主税, 籏野 悠里, Memtily Nassirhadjy, 佐藤 真理, 坂井 詠子. 大気圧電顕による骨組織のリン酸カルシウムと破骨細胞の水中観察と免疫電顕. 2019. 29. 1. 142-142
more...
Books (2):
  • Studies in Natural Products Chemistry (edited by Atta-UR-Rahman) Volume 72
    Elsevier 2022 ISBN:9780128239445
  • COFFEE IN HEALTH AND DISEASE PREVENTION
    ACADEMIC PRESS 2015 ISBN:9780124095175
Lectures and oral presentations  (109):
  • Effects of a large Rab protein on muscle satellite cells and myogenesis.
    (2022)
  • Rufy4 regulates bone resorption by osteoclasts via the RUN domain
    (2022)
  • Coronin1C is a GDP-specific Rab44 effector that controls osteoclast formation by regulating cell motility in macrophages
    (2022)
  • Differentiation mechanisms of myoblasts into myotubes controlled by a large Rab protein
    (2022)
  • Impaired endochondral ossification in Keap1-deficient mice: observation by X-ray μCT and atmospheric scanning electron microscopy in liquid
    (2021)
more...
Works (10):
  • 膜輸送関連分子による破骨細胞分化制御
    2014 -
  • 酸化ストレス応答系による破骨細胞分化制御
    2014 -
  • 歯周病における上皮細胞の病態解析
    2010 - 2013
  • 鉄を介した破骨細胞分化調節機構の分子メカニズムを解明する
    2010 - 2013
  • 破骨細胞におけるアスパラギン酸プロテアーゼの機能
    2008 - 2011
more...
Education (1):
  • - 1984 Nagasaki University School of Pharmaceutical Sciences
Professional career (1):
  • 博士(歯学) (長崎大学)
Work history (5):
  • 2007 - 現在 Nagasaki University Graduate School of Biomedical Sciences
  • 2004 - 2007 Nagasaki University Graduate School of Biomedical Sciences
  • 1995 - 2004 Nagasaki University School of Dentistry
  • 1993 - 1993 米国ニューヨーク州 メモリアルスローンケタリング癌センター ボランティアスタッフ
  • 1984 - 1992 Nagasaki University School of Dentistry
Association Membership(s) (6):
日本鉄バイオサイエンス学会 ,  日本細菌学会 ,  日本骨代謝学会 ,  日本生化学会 ,  歯科基礎医学会 ,  日本薬理学会
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