Rchr
J-GLOBAL ID:200901015227740448   Update date: Feb. 15, 2021

Okamura Nobuyuki

オカムラ ノブユキ | Okamura Nobuyuki
Affiliation and department:
Job title: 教授
Other affiliations (1):
Homepage URL  (1): https://tmpu-pharmacol.org/
Research field  (5): Neuroscience - general ,  Cognitive sciences ,  Pharmacology ,  Pharmacology ,  Radiology
Research keywords  (34): モノアミンオキシダーゼ ,  アストロサイト ,  包括脳ネットワーク ,  統合脳・統合脳 ,  small GTPase Rho ,  ヒスタミンH1受容体占拠率 ,  非定型抗精神病薬 ,  internalization ,  ヒスタミン神経系 ,  H_1受容体占拠率 ,  ブレーキ反応時間 ,  アミロイドAβ ,  記憶・学習 ,  ヒスタミンH2受容体 ,  ハロペリドール ,  Dynamin ,  ドキセピン ,  アセチルコリンエステラーゼ ,  ヒスタミン ,  P-糖タンパク ,  抗ヒスタミン薬 ,  神経原線維変化 ,  プローブ ,  タウ蛋白 ,  老化 ,  fMRI ,  注意 ,  感情 ,  認知 ,  老人斑 ,  イメージング ,  アミロイドβ蛋白 ,  アルツハイマー病 ,  PET
Research theme for competitive and other funds  (28):
  • 2018 - 2023 Imaging neurofibrillary tangles and astrogliosis for the clarification of the pathogenesis of Alzheimer's disease
  • 2019 - 2022 Development of protein-specific PET molecular imaging in neurodegenerative disorders
  • 2018 - 2022 神経原線維変化とアストログリオーシスの選択的描出によるアルツハイマー病の病態解明
  • 2016 - 2019 Search of conformation-specific PET probe
  • 2014 - 2019 Elucidatio of neural network disruption mechanisms by protein specific PET imaging
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Papers (353):
  • Pradith Lerdsirisuk, Ryuichi Harada, Yoshimi Hayakawa, Yuki Shimizu, Yoichi Ishikawa, Ren Iwata, Yukitsuka Kudo, Nobuyuki Okamura, Shozo Furumoto. Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease. Nuclear Medicine and Biology. 2021. 93. 11-18
  • Ryuichi Harada, Yoshimi Hayakawa, Michinori Ezura, Pradith Lerdsirisuk, Yiqing Du, Yoichi Ishikawa, Ren Iwata, Miho Shidahara, Aiko Ishiki, Akio Kikuchi, et al. 18F-SMBT-1: A Selective and Reversible PET Tracer for Monoamine Oxidase-B Imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2021. 62. 2. 253-258
  • Takahiro Morito, Ryuichi Harada, Ren Iwata, Yiqing Du, Nobuyuki Okamura, Yukitsuka Kudo, Kazuhiko Yanai. Synthesis and pharmacokinetic characterisation of a fluorine-18 labelled brain shuttle peptide fusion dimeric affibody. Scientific Reports. 2021. 11. 1
  • Jung Lung Hsu, Shih Hsin Chen, Ing Tsung Hsiao, Chin Song Lu, Tzu Chen Yen, Nobuyuki Okamura, Kun Ju Lin, Yi Hsin Weng. 18F-THK5351 PET imaging in patients with progressive supranuclear palsy: associations with core domains and diagnostic certainty. Scientific Reports. 2020. 10. 1
  • Kuo-Lun Huang, Ing-Tsung Hsiao, Meng-Yang Ho, Jung-Lung Hsu, Yeu-Jhy Chang, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Yi-Ming Wu, Kuan-Yi Wu, et al. Investigation of reactive astrogliosis effect on post-stroke cognitive impairment. Journal of Neuroinflammation. 2020. 17. 1
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MISC (392):
Patents (10):
more...
Lectures and oral presentations  (1):
  • Molecular PET Imaging of Acetylcholine Esterase, Histamine H1 Receptor and Amyloid Deposits in Alzheimer Disease
    (IFMBE Proceedings 2009)
Professional career (1):
  • 医学博士 (東北大学)
Work history (9):
  • 2016/04 - 現在 Tohoku Medical and Pharmaceutical University Division of Pharmacology, Faculty of Medicine Professor
  • 2009 - 2016 Tohoku University Graduate School of Medicine
  • 2007 - 2009 Tohoku University Graduate School of Medicine
  • 2009 - メルボルン大学 MHRI Senior Research Officer
  • 2003 - 2006 東北大学 医学系研究科・大学院 助手
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Committee career (4):
  • 2016 - 日本認知症予防学会 評議員
  • 2016 - 日本認知症学会 代議員
  • 2009 - 日本薬理学会 評議員
  • 2009 - 日本老年医学会 代議員
Awards (13):
  • 2017 - 臨床薬理研究振興財団 研究大賞
  • 2016 - Hiruma-Wagner Award
  • 2016 - EJNMMI - EANM Springer Award
  • 2015 - 日本認知症学会学会賞
  • 2014 - SNMMI Image of the Year
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Association Membership(s) (7):
日本認知症予防学会 ,  THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS ,  THE JAPANESE SOCIETY OF INTERNAL MEDICINE ,  JAPAN SOCIETY FOR DEMENTIA RESEARCH ,  THE JAPAN GERIATRICS SOCIETY ,  THE JAPANESE SOCIETY OF NUCLEAR MEDICINE ,  THE JAPANESE PHARMACOLOGICAL SOCIETY
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