Sato Takashi

サトウタカシ | Sato Takashi

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： http://seimeibunseki.org

Research field (1)： Pharmaceuticals - health and biochemistry

Research keywords (4)： ATTRアミロイドーシス , タンパク質品質管理 , フォールディング , レドックス

Research theme for competitive and other funds (9)：

2021 - 2024 ATTRアミロイドーシスの加齢依存的な発症を制御する環境要因の同定
2018 - 2021 Elucidation of the molecular mechanism underlying TTR monomer unfolding and aggregate formation and its application to therapeutic approaches for FAP
2017 - 2020 Developments of functional single-chain antibodies and unraveling of mechanisms of diseases associated with advanced glycation end-products
2016 - 2018 Development of highly sensitive imaging method by use of functional single-chain antibodies that discriminate the structure of advanced glycation endproduct
2016 - 2018 Peptide ligand screening of transthyretin protein-protein interaction inhibitor using phage display system

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Papers (48)：

Sena Kamesawa, Mizuki Ogawa, Yoshiki Funakoshi, Masaya Kato, Shosei Kai, Mana Namikawa, Kyo Okazaki, Takashi Sato, Yoshihiro Kobashigawa, Hiroshi Morioka. Evaluation of the cyclic single-chain Fv antibody derived from nivolumab by biophysical analyses and in vitro cell-based bioassay. Journal of biochemistry. 2024
Yan Du, Yoshihiro Kobashigawa, Kyo Okazaki, Mizuki Ogawa, Tomoyuki Kawaguchi, Takashi Sato, Hiroshi Morioka. Structure-based design, biophysical characterization, and biochemical application of the heterodimeric affinity purification tag based on the Schistosoma japonicum glutathione-S-transferase (SjGST) homodimer. The Journal of Biochemistry. 2024
Yuki Inada, Yuichiro Ono, Kyo Okazaki, Takuma Yamashita, Tomoyuki Kawaguchi, Shingo Kawano, Yoshihiro Kobashigawa, Shoko Shinya, Chojiro Kojima, Tsuyoshi Shuto, et al. Hydrogen bonds connecting the N-terminal region and the DE loop stabilize the monomeric structure of transthyretin. Journal of biochemistry. 2023. 174. 4. 355-370
Kyo Okazaki, Yoshihiro Kobashigawa, Hikari Morita, Soichiro Yamauchi, Natsuki Fukuda, Chenjiang Liu, Yuya Toyota, Takashi Sato, Hiroshi Morioka. Molecular Dynamics-Based Design and Biophysical Evaluation of Thermostable Single-Chain Fv Antibody Mutants Derived from Pharmaceutical Antibodies. ACS Omega. 2023
Ryoko Sasaki, Mary Ann Suico, Keisuke Chosa, Yuriko Teranishi, Takashi Sato, Asuka Kagami, Shunsuke Kotani, Hikaru Kato, Yuki Hitora, Sachiko Tsukamoto, et al. Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors. Journal of Pharmacological Sciences. 2023. 151. 1. 54-62

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MISC (49)：

楊一帆, 楊一帆, 岡崎匡, 田所高志, 喜多俊介, 佐藤卓史, 小橋川敬博, 前仲勝実, 森岡弘志. 一本鎖抗体のVL領域に存在する2つのcis-Proを標的とした抗体工学研究. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
大水良太, 並河真菜, 豊田湧也, 佐藤卓史, 森岡弘志, 木本祐, 森小夏, 関口光広, 小橋川敬博. 薬物間相互作用に関わる核内受容体と薬物との相互作用の迅速評価法の構築. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
胡艶萍, 佐藤卓史, 福田夏希, 小橋川敬博, 堀内正隆, 増田豪, 大槻純男, 森岡弘志. 血液試料を用いたバイオマーカー探索のための新規アフィニティー精製システムの開発. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
稲田祐貴, 小野祐一朗, 小橋川敬博, 首藤剛, 甲斐広文, 森岡弘志, 佐藤卓史. トランスサイレチンのアミロイド線維形成初期過程における新規中間体の同定とその機能解析. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
稲田祐貴, 小野祐一朗, 佐々木亮子, 小橋川敬博, 首藤剛, 甲斐広文, 森岡弘志, 佐藤卓史. アミロイド形成過程におけるトランスサイレチンの新規中間体構造の機能解析. 日本薬学会九州支部大会講演要旨集. 2019. 36th

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Patents (3)：

環状一本鎖抗体
終末糖化産物の濃縮方法
PEG化環状一本鎖抗体

Professional career (1)：

博士(薬学) (熊本大学)

Work history (8)：

2012 - 2015 Kumamoto University Institute of Molecular Embryology and Genetics
2015 - Kumamoto University Faculty of Life Sciences
2015 - Assistant Professor,Faculty of Life Sciences(Pharmaceutical sciences group),Kumamoto University
2011 - 2012 Fukushima Medical University School of Medicine, Institute of Biomedical Sciences
2011 - 2012 Assistant Professor

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Association Membership(s) (4)：

日本生化学会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , 日本薬学会 , 日本分子生物学会

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