Rchr
J-GLOBAL ID：200901015588194642
Update date: Jun. 25, 2024
Doh-ura Katsumi
ドウウラ カツミ | Doh-ura Katsumi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
https://www.neurochemistry.med.tohoku.ac.jp
Research field (1)：
Neurology
Research keywords (5)：
プリオン
, 治療開発
, タンパク質コンフォメーション病
, ケミカルバイオロジー
, 神経化学
Research theme for competitive and other funds (17)：
- 2022 - 2025 セルロースエーテルが関わるプリオンに対する生体防御機構の解明
- 2021 - 2023 異常蛋白質の排除機構に関する新原理の探究
- 2019 - 2022 Identification of cellulose ether susceptibility genes involved in suppression of prion disease development
- 2017 - 2020 Study for bringing a new dimension in the pathogenesis of prion disease.
- 2016 - 2019 Analysis of host genetic factors associated with disease suppression against prion diseases.
- 2012 - 2015 Elucidation of the epigenetic gene regulation related to the inhibition of prion formation
- 2010 - 2012 Investigation on host defense mechanism and search for new therapeutic targets against prion diseases
- 2007 - 2008 Research of therapeutic strategy applying to both prion diseases and Alzheimer's disease
- 2006 - 2008 siRNAを用いた早期エンドゾーム中のプリオン複製補助因子の探索
- 2004 - 2005 Analysis of Serum Proteins of Scrapie and BSE and Application to the Diagnosis.
- 2004 - 2004 ヤコブ病に対する実験的治療法に関する国際連絡会議の企画
- 2002 - 2004 Development and pharmacological analysis of therapeutic drugs for conformation diseases and prion diseases
- 2002 - 2003 プリオン・バイオイメージング法開発に関する基礎研究
- 2001 - 2003 Development of prophylactic and therapeutic anti-prion drugs for the patients at high risks
- 2002 - 2002 非通常病原体プリオンの分子機構
- 2002 - 2002 プリオン病の化学療法剤開発に関する研究
- 1999 - 2000 Prion protein and tau protein gene analysis in frontotemporal dementia in Japan
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Papers (126)：
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Kenta Teruya, Ayumi Oguma, Sara Iwabuchi, Keiko Nishizawa, Katsumi Doh-ura. Improvement of anti-prion efficacy with stearoxy conjugation of hydroxypropyl methylcellulose in prion-infected mice. Carbohydrate Polymers. 2024. 337
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Kenta Teruya, Ayumi Oguma, Sara Iwabuchi, Keiko Nishizawa, Katsumi Doh-ura. Combination of Styrylbenzoazole Compound and Hydroxypropyl Methylcellulose Enhances Therapeutic Effect in Prion-Infected Mice. Molecular Neurobiology. 2023
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Kenta Teruya, Ayumi Oguma, Satoko Takahashi, Miki Watanabe-Matsui, Sachiyo Tsuji-Kawahara, Masaaki Miyazawa, Katsumi Doh-ura. Anti-prion activity of cellulose ether is impaired in mice lacking pre T-cell antigen receptor α, T-cell receptor δ, or lytic granule function. International Immunopharmacology. 2022. 107. 108672-108672
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Kenta Teruya, Katsumi Doh-Ura. Therapeutic development of polymers for prion disease. Cell and tissue research. 2022. Online ahead of print. 1. 349-365
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Kenta Teruya, Sara Iwabuchi, Yuki Watanabe, Rikiya Tsuchida, Miki Watanabe-Matsui, Hiroyuki Konno, Katsumi Doh-ura. Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains. Biochimica et biophysica acta. General subjects. 2022. 1866. 4. 130094-130094
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MISC (139)：
Patents (2)：
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コンフォメーション病医薬組成物
-
異常型プリオン蛋白質の濃縮方法、および除去方法
Books (2)：
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Prions - Food and Drug Safety
Springer 2005
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脳科学研究の現状と課題
じほう社 2003
Lectures and oral presentations (134)：
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Our Quest for Anti-prion Compounds 2022.
(Asian Pacific Prion Symposium 2022.)
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Structure-Activity relationship of curcumin-related compounds in ScN2a and N167.
(Asian Pacific Prion Symposium 2022.)
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Characterization of the actions of CRANAD on two prion strains and PrP-amyloid.
(第59回ペプチド討論会)
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フェロトーシス阻害剤による異常型プリオンタンパク質蓄積抑制機構の解明
(第44回日本分子生物学会年会)
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Photoreaction-induced SDS-resistant PrPSc/res oligomer formation.
ｍore...
Professional career (1)：
Committee career (4)：
- 2011/07 - 現在 Asian Pacific Society of Prion Research 理事
- 2014/04 - 2018/03 食品安全委員会 プリオン専門調査会 専門委員
- 2015/09 - 2017/10 Asian Pacific Society of Prion Research 理事長
- 2005/01 - 2013/01 生物由来製品感染等被害判定調査会 薬事・食品衛生審議会専門委員
Association Membership(s) (1)：
Asian Pacific Society of Prion Research
