Rchr
J-GLOBAL ID：200901017289300633   Update date: Nov. 27, 2024

Matsushita Takahiko

マツシタ タカヒコ | Matsushita Takahiko
Affiliation and department：
Saitama University Graduate School of Science and Engineering

About Saitama University Graduate School of Science and Engineering


Job title： Assistant Professor
Homepage URL  (2)： http://md.fms.saitama-u.ac.jp ,  http://md.fms.saitama-u.ac.jp/
Research field  (7)： Polymer chemistry ,  Chemical biology ,  Nanomaterials ,  Bio-, chemical, and soft-matter physics ,  Functional biochemistry ,  Immunology ,  Tumor biology
Research keywords  (22)： Glycan-Protein Interactions ,  Tumor-Associated Carbohydrates ,  Mucin-Type Glycopeptides ,  Microwave-Assisted Solid-Phase Synthesis ,  Chemoenzymatic Synthesis ,  Glycopeptide Synthesis ,  Glycopolymer Design ,  Dendrimer Chemistry ,  MALDI-TOF/TOF Mass Spectrometry ,  Fluorescence Resonance Energy Transfer (FRET) ,  High-throughput Screening ,  Microarray Technology ,  Epitope Mapping ,  Cancer Immunology ,  Diagnostic Tool Development ,  Enzyme Inhibitors ,  Viral Inhibition ,  Toxin Neutralization ,  Post-Translational Modifications ,  Bioconjugation ,  Nanoparticle Platforms ,  Structure-Activity Relationships
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 多価型VHH抗体を基盤とした光免疫治療薬の開発
  • 2021 - 2022 Development of bispecific molecule using VHH antibody
  • 2020 - 2022 Development of a highly sensitive immunochromatographic detection system
  • 2019 - 2022 Prodrug modification to enhance the safety and efficacy of anti-influenza drugs
  • 2018 - 2019 院内感染の検出率を高めるクロストリジウム・ディフィシル感染症迅速診断ツール
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Papers (61)：
  • Miyairi, K., Arai, H., Matsushita, T., Koyama, T., Hatano, K., Matsuoka, K. Interpenetrating Polymer Network Capturing FRET-Sensitive Polymers Available for an Enzyme Assay. Biomacromolecules. 2024. 25. 8
  • Zhang, J., Koyama, T., Matsushita, T., Hatano, K., Matsuoka, K. Use of an oxazolidinone derivative of a sialyl thioglycoside as a useful glycosyl donor for α-favorable glycosidation with simple alcohols. Tetrahedron Letters. 2024. 146
  • Miyairi, K., Matsushita, T., Koyama, T., Hatano, K., Matsuoka, K. Preparation of fluorogenic glycopolymers having mannose moieties that can be used for determining the affinity of lectins by means of intermolecular FRET. Journal of Molecular Structure. 2024. 1306
  • Omiya, S., Yamochi, H., Koyama, T., Hatano, K., Matsuoka, K., Matsushita, T. pH-Dependent proteolytic activity of histidine-pendant polyacrylamides. European Polymer Journal. 2024. 209
  • Matsuoka, K., Nakada, J., Nakazato, M., Matsushita, T., Koyama, T., Hatano, K. Preparation of a water-soluble polymer having pheophorbide a side chains using glycopolymer assembly. Tetrahedron Letters. 2024. 138
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MISC (37)：
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Patents (8)：
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Books (6)：
  • 注目の論文「エーテル結合をクリック反応で切断する」
    2019
  • Polysaccharide Interface Integrated with VHH Antibody
    2019
  • 新たな疾患検出・診断薬の創出に向けて
    埼経協ニュース398号, 埼玉県経営者協会 2017
  • 異物の新しいパートナー
    サイ・テクこらむ, 埼玉新聞 2016
  • Methods in Enzymology vol.478 " Novel Synthesis of Functional Mucin Glycopeptides Containing Both N- and O-glycans."
    Elsevier Inc. 2010 ISBN:9780123810014
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Lectures and oral presentations  (191)：
  • 双性イオンを含む脂質膜接着分子の合成 (IV) ~ダンシル修飾2価スルホベタインの合成~
    (第14回CSJ化学フェスタ2024 2024)
  • ヒトインフルエンザウイルスに関するオリゴ糖鎖の合成 (IV): 三糖骨格の構築
    (第14回CSJ化学フェスタ2024 2024)
  • トレハロースの化学修飾と機能化(VIII): 各種2価GlcNAc誘導体のレクチンに対する挙動
    (第14回CSJ化学フェスタ2024 2024)
  • FRET効果を利用した新規アミラーゼ基質の合成(VIII): 八糖ポリマー基質の合成
    (第14回CSJ化学フェスタ2024 2024)
  • 双性イオン修飾シクロデキストリンの合成研究(VIII):β-CDの水酸基一点修飾
    (第14回CSJ化学フェスタ2024 2024)
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Education (2)：
  • 2000 - 2005 Hokkaido University Graduate School of Science Division of Biological Sciences
  • 1996 - 2000 Hokkaido University Faculty of Science Devision of Biological Sciences (Macromolecular Functions)
Professional career (1)：
  • Ph.D. in Science (Hokkaido University)
Work history (4)：
  • 2015/10 - 現在 埼玉大学 Graduate School of Science and Engineering Assistant Professor
  • 2013/07 - 2015/09 Wayne State University Department of Chemistry (Prof. David Crich) Research Scholar
  • 2010/11 - 2013/06 Hokkaido University Faculty of Advanced Life Science Specially Appointed Assistant Professor
  • 2005/07 - 2010/10 National Institute of Advanced Industrial Science and Technology Research Associate
Awards (1)：
  • 2011/05 - THE SOCIETY OF POLYMER SCIENCE, JAPAN Award for Encouragement of Research in Polymer Science Chemical and Enzymatic Synthesis of MUC1 Glycopeptide Library
Association Membership(s) (3)：
THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH ,  THE CHEMICAL SOCIETY OF JAPAN ,  THE SOCIETY OF POLYMER SCIENCE, JAPAN
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