Rchr
J-GLOBAL ID：200901017289300633   Update date: Feb. 01, 2024

Matsushita Takahiko

マツシタ タカヒコ | Matsushita Takahiko
Affiliation and department：
Saitama University Graduate School of Science and Engineering

About Saitama University Graduate School of Science and Engineering


Job title： Assistant Professor
Homepage URL  (2)： http://md.fms.saitama-u.ac.jp ,  http://md.fms.saitama-u.ac.jp/
Research field  (3)： Functional solid-state chemistry ,  Synthetic organic chemistry ,  Biochemistry
Research keywords  (10)： solid-phase synthsis ,  polymer-supported synthesis ,  glycosyltransferase ,  antibody ,  epitope ,  dendrimer ,  microarray ,  carbohydrate ,  chemoenzymatic synthesis ,  glycopeptide
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 多価型VHH抗体を基盤とした光免疫治療薬の開発
  • 2021 - 2022 Development of bispecific molecule using VHH antibody
  • 2020 - 2022 Development of a highly sensitive immunochromatographic detection system
  • 2019 - 2022 Prodrug modification to enhance the safety and efficacy of anti-influenza drugs
  • 2018 - 2019 院内感染の検出率を高めるクロストリジウム・ディフィシル感染症迅速診断ツール
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Papers (50)：
  • Takahiko Matsushita, Hinako Yamochi, Shinzo Omiya, Tetsuo Koyama, Ken Hatano, Koji Matsuoka. Proteolytic polymer: polyacrylamides functionalized with amino acids cleave bovine and human serum albumins. Bioorganic & Medicinal Chemistry. 2023. 92. 117422-117422
  • Rukshana Mohamad-Ramshan, Chennaiah Ande, Takahiko Matsushita, Klara Haldimann, Andrea Vasella, Sven N. Hobbie, David Crich. Synthesis of 4-O-(4-amino-4-deoxy-β-D-xylopyranosyl)paromomycin and 4-S-(β-D-xylopyranosyl)-4-deoxy-4′-thio-paromomycin and evaluation of their antiribosomal and antibacterial activity. Tetrahedron. 2023. 135. 133330-133330
  • Ryota Adachi, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano, Koji Matsuoka. Synthetic assembly of a series of glycopolymers having sialyl α2-3 lactose moieties connected with longer spacer arms. Bioorganic & Medicinal Chemistry. 2023. 81. 117209-117209
  • Ryota Adachi, Takahiko Matsushita, Tetsuo Koyama, Ken Hatano, Koji Matsuoka. Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation. Polymers. 2023. 15. 4. 998
  • Takahiko Matsushita, Naomichi Toda, Tetsuo Koyama, Ken Hatano, Koji Matsuoka. Dendritic maleimide-thiol adducts carrying pendant glycosides as high-affinity ligands. Bioorganic Chemistry. 2022. 128. 106061-106061
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MISC (37)：
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Patents (6)：
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Books (6)：
  • 注目の論文「エーテル結合をクリック反応で切断する」
    2019
  • Polysaccharide Interface Integrated with VHH Antibody
    2019
  • 新たな疾患検出・診断薬の創出に向けて
    埼経協ニュース398号, 埼玉県経営者協会 2017
  • 異物の新しいパートナー
    サイ・テクこらむ, 埼玉新聞 2016
  • Methods in Enzymology vol.478 " Novel Synthesis of Functional Mucin Glycopeptides Containing Both N- and O-glycans."
    Elsevier Inc. 2010 ISBN:9780123810014
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Lectures and oral presentations  (70)：
  • Maleimide-functionalized Carbosilane Dendrimers as Multivalent Platforms
    (International Congress on Pure & Applied Chemistry Kota Kinabalu (ICPAC KK) 2022, Kota Kinabalu, Sabah, Malaysia 2022)
  • Bivalent N-Acetylglucosamine Glycosides: Effect of Scaffold Constraint on Lectin-Carbohydrate Interaction
    (International Congress on Pure & Applied Chemistry Langkawi (ICPAC Langkawi) 2018)
  • 疎水的な薬剤を安定に保持するためのがん標的DDSキャリア分子の合成
    (第8回CSJ化学フェスタ2018 2018)
  • 蛍光増感型インフルエンザ検出薬の改良
    (第8回CSJ化学フェスタ2018 2018)
  • シアル酸部位を含む糖修飾型金ナノ微粒子の合成 (I): 糖鎖骨格の構築と金ナノ微粒子の作成
    (第8回CSJ化学フェスタ2018 2018)
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Education (2)：
  • 2000 - 2005 Hokkaido University Graduate School of Science Division of Biological Sciences
  • 1996 - 2000 Hokkaido University Faculty of Science Devision of Biological Sciences (Macromolecular Functions)
Professional career (2)：
  • Ph.D. in Science (Hokkaido University)
  • Ms. in Science (Hokkaido University)
Work history (4)：
  • 2015/10 - 現在 埼玉大学 Graduate School of Science and Engineering Assistant Professor
  • 2013/07 - 2015/09 Wayne State University Department of Chemistry (Prof. David Crich) Research Scholar
  • 2010/11 - 2013/06 Hokkaido University Faculty of Advanced Life Science Specially Appointed Assistant Professor
  • 2005/07 - 2010/10 National Institute of Advanced Industrial Science and Technology Research Associate
Awards (1)：
  • 2011/05 - THE SOCIETY OF POLYMER SCIENCE, JAPAN Award for Encouragement of Research in Polymer Science Chemical and Enzymatic Synthesis of MUC1 Glycopeptide Library
Association Membership(s) (3)：
THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH ,  THE CHEMICAL SOCIETY OF JAPAN ,  THE SOCIETY OF POLYMER SCIENCE, JAPAN
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