Kitagawa Hiroshi

2016 - 2019 Regulatory mechanism of chondroitin sulfate expression and glycobiology in disease

2016 - 2017 統合的神経機能の制御を標的とした糖鎖の作動原理解明

2014 - 2017 Involvement of the decreased chondroitin sulfate production in the presence of multinucleated blastomeres

2013 - 2017 Glycobiology in disease based on the functional analysis of chondroitin sulfate chains

2013 - 2016 Dysregulation of Sulfated Glycosaminoglycan Biosynthesis is Implicated in Inflammatory Response

2011 - 2016 Regulatory mechanisms of neuronal activity by chondroitin sulfate chains

2011 - 2016 Deciphering sugar chain-based signals regulating integrative neuronal functions

2012 - 2014 Golgi stress response by proteoglycans

2010 - 2011 Proteoglycan quality control mechanisms by the tumor suppressor gene EXTL2

2009 - 2011 Functional analysis of sulfated glycosaminoglycans aimed at elucidating the pathology and therapy

2007 - 2008 Biosynthetic mechanism and functional analysis of sulfated glycosaminoglycans aimed at elucidating the pathology and therapy

2006 - 2007 Functional analysis of glycosaminoglycans as a potential drug target and the decoding of carbohydrate signaling of the functional domains

2004 - 2005 Studies on the biosynthetic mechanism and regulation of the expression of sulfated glycosaminoglycans

2004 - 2005 Development of a fundamental technology, which is applicable to drug development and therapeutic applications through analysis of sulfated glycosaminoglycan chains

2002 - 2003 Studies on Biosynthetic Mechanism of the Sulfated Glycosaminoglycans

2001 - 2003 Analysis of the biosynthetic mechanism and functions of glycosaminogycans by manipulating the genes encoding biosynthetic enzymes.

2000 - 2003 Development of the haparan sulfate-based anti-cancer drugs

1999 - 2000 パートタイムプロテオグリカンへの糖鎖付加の分子スイッチの同定とその機能調節の解明

1999 - 2000 グリコサミノグリカン鎖生合成に関わるグルクロン酸転移酵素遺伝子の構造と発現機構

1997 - 2000 神経突起伸長と血管新生におけるグリコサミノグリカン糖鎖の分子認識

1997 - 1999 Development of a universal sequencing method for sulfated glycosaminoglycans

1999 - Functional Analysis of Complex Carbohydrates by Sugar Remodeling

1997 - 1998 コンドロイチン硫酸生合成に関わるN-アセチルガラクトサミン転移酵素の精製と性質

1996 - 1996 プロテオグリカンの糖-タンパク質結合領域に作用する新しいα-GalNAc転移酵素

1995 - 1995 コンドロイチン硫酸生合成に関わるN-アセチルガラクトサミン転移酵素の研究

1994 - 1995 Structure and Biosynthesis of Carbohydrate-Protein Linkage Region of Dermatan Sulfate and Chondroitin Sulfate

1994 - Studies on Glycosyltransferases involved in the biosynthesis of complex carbohydrate structures

1990 - 1991 Biological significance, expression and characteristics of cancer associated carbohydrate antigen

1990 - 1990 癌関連複合糖質糖鎖に対する単クローン抗体の作製とその応用

細胞外微少環境による神経活動制御や軟骨分化制御機構の解明

糖鎖リモデリングによる複合糖質糖鎖の機能の解明

複合糖質糖鎖生合成に関わる糖転移酵素および硫酸基転写酵素の研究