Rchr

J-GLOBAL ID：200901017588714975 Update date: Nov. 18, 2024

Shimokawa Hiroaki

シモカワヒロアキ | Shimokawa Hiroaki

Affiliation and department：
Job title： Vice Dean, Graduate School
Other affiliations (1)：

Tohoku University Graduate School of Medicine Visiting Professor, Emeritus Professor, Graduate School of Medciine

Homepage URL (2)： http://db.tohoku.ac.jp/whois/detail/4ba6f3ac408eb0ee4601a47f068c9ada.html , http://db.tohoku.ac.jp/whois/e_detail/4ba6f3ac408eb0ee4601a47f068c9ada.html

Research field (3)： Hematology and oncology , Internal medicine - General , Cardiology

Research keywords (6)：血管生物学 , 肺高血圧症 , 動脈硬化 , 心不全 , 虚血性心臓病 , 循環器内科全般、虚血性心臓病、心不全、動脈硬化、肺高血圧症、血管生物学

Research theme for competitive and other funds (81)：

1999 - 現在音波を用いた低侵襲性血管新生療法の開発
1979 - 現在冠攣縮の成因に関する基礎的・臨床的研究
1979 - 現在血管内皮機能に関する研究
1979 - 現在慢性心不全に関する大規模疫学研究
2019 - 2022 Discovery of new etiologic molecules for thoracic aortic aneurysm and development of therapeutic strategies (early diagnosis / drug discovery)

2016 - 2019 The effect of new generation drug-eluting stent on coronary vasomotion

2016 - 2019 Explorateive research of biomarkers for coronary microvascular dysfunction in the patients with vasospastic angina

2016 - 2018 Functional analysis of novel cardiovascular protective factor

2015 - 2018 Basic and clinical research on novel targets of pulmonary arterial hypertension

2014 - 2018 新しいRho-kinase阻害薬による肺高血圧治療効果の検討

2014 - 2017 Nationwide database platform of cardiovascular diseases to measure quality indicator and develop predicting model

2013 - 2016 Right ventricular fibrosis/ Rho-kinase pathway in the development of right heart failure

2013 - 2016 Extracorporeal low-energy shock wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction

2013 - 2016 Circadian variation of Rho-kinase activity in circulating leukocytes of patients with vasospastic angina.

2013 - 2015 The possibility of pleiotropic effects of Novel Oral Anticoagulants (NOAC) on Rho-kinase-cyclophilin A System

2012 - 2015 Impact of new generation drug-eluting stent on coronary vasomotion

2012 - 2015 Feasibility of Clininical Application of Synthesized 18-lead ECG in Atrial Fibrillation

2008 - 2014 Signaling Functions of Reactive Oxygen Species

2011 - 2013 Rho-kinase activity in circulating neutrophils as a useful biomarker for diagnosis and disease activity assessment of vasospastic angina

2011 - 2013 内皮由来過分極反応におけるAMP Kinaseの役割の解明

2011 - 2012 The role of SmgGDS in the pleiotropic effects by statins

2010 - 2012 Establishment of the therapy of diastolic heart failure

2010 - 2012 Molecular mechanisms for NOSs-mediated responses in microvessels

2010 - 2012 Mechanism of Manifestation for Disturbance of Endocardial CoronaryMicrocirculation in Diabetes Mellitus by Measurements of Myocardial Radical Molecules

2008 - 2012 The roleof H_20_2as an endothelium-derived relaxing factors (EDRFs)

2009 - 2011 Low-energy shock wave therapy for chronic heart failure

2009 - 2011 Development of Novel Biomarker to Predict Cardiovascular Diseases

2008 - 2010 Molecular Mechanisms of Hyper-contraction of Drug-eluting Stent Implanted Coronary Arteries

2008 - 2010 Elucidation of the significance of the nitric oxide synthase system in vivo by the use of mice lacking all nitric oxide synthases

2008 - 2009 動脈硬化病変の進展および破綻における免疫系細胞活性化分子の役割の解明

2007 - 2008 Long-term Inhibition of Rho-kinase Ameliorates Diastolic Heart Failure in Hypertensive Rats

2007 - 2008 Molecular mechanisms for beneficial effects of low-energy shock wave therapy on myocardial ischemia

2006 - 2007 肺高血圧症の分子機構における免疫系細胞活性化分子の役割の解明

2006 - 2007 The shock wave as a new energy source of therapy for tachyarrhytmias

2006 - 2007 心血管病の成因におけるRho-kinase経路の意義の解明

2005 - 2007 Elucidation of roles of the nitric oxide synthase system on the basis of the development of mice lacing all nitric oxide synthase isoforms

2005 - 2006 Investigation of the mechanisms of diabetic vitreoretinopathy and its pharmaceutical regulation

2005 - 2006 Improvement for myocardial preservation using extracorporeal shock wave

2004 - 2006 Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)

2004 - 2005 Identification of genetic factors responsible for the pathogenesis of coronary vasospasm, that is more prevalent in the Japanese, resulting in ischemic heart disease, and characterization of its molecular mechanism.

2004 - 2005 冠攣縮性狭心症におけるRho-kinase活性化の機序の解明

2003 - 2005 International Collaboration Study on the Racial Difference in Coronary Vasospasm

2003 - 2005 High-performance Stent Technology

2003 - 2004 Role of reactive oxygen species within the vasomotor center of the brain in hypertension

2000 - 2004 Identification of genes associated with bronchial asthtima, atopy, schizophrenia, and abnormal serum lipid profile

2002 - 2003 The Role of RhoA/Rho-kinase System in the Deterioration of Coronary Microcirculation in Ischemic Heart Disease

2002 - 2003 Clarification of the mechanisms for vascular neuronal nitric oxide synthase expression

2002 - 2003 The development of bone marrow injection therapy for chronic myocardial ischemia

2001 - 2003 Development of Nanomedicine for the Treatment of Cardiovascular Diseases

2001 - 2003 Role of Rho/Rho-kinase-mediated pathway in the pathogenesls of atherosclerosis

2001 - 2002 Identification of endothelium-derived hyperpolarizing factor (EDHF) in human arteries.

2001 - 2002 Role of Rho-kinase within the brain in abnormality of regulation of sympathetic nervous system in hypertension

2001 - 2002 Elucidating the mechanism of heart failure using mouse model of dilated cardiomyopathy

2000 - 2002 Basic and clinical studies on the role of inflammatory mechanisms in the pathogenesis ischemic heart disease

2000 - 2002 Develop of High Performance Stents

2000 - 2001 Non-invasive evaluation of free radical reactions accompanied with induction and development of heart failure by in vivo ESR-CT

2000 - 2000 内皮由来過分極因子(EDHF)は過酸化水素(H_2O_2)である可能性

2000 - 2000 動脈硬化の分子機構におけるRho/Rho-kinase系の役割

1998 - 2000 Development of intracellular therapy to induce a regression of coronary arteriosclerotic lesions

1998 - 2000 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1

1997 - 1999 Pathogenesis and treatment for anesthesia-related coronary arterial spasm

1997 - 1999 Experimental and Clinical Studies on the Role of Inflammatory Mechanisms in the Pathogenesis of Ischemic Heart Disease

1998 - 1998 内皮由来過分極因子(EDHF)は内皮型一酸化窒素合成酵素由来である可能性-ノックアウトマウスを用いた検討-

1998 - 1998 血管リモデリングの成因における外膜の炎症性・増殖性機序の役割遺伝子導入法を用いた検討

1996 - 1998 THE REGULATION OF ENDOTHELIAL CONSTITUTIVE NITRIC OXIDE SYNTHASE IN REGENERATED ENDOTHLIAL CELLS

1996 - 1998 Development of Chronic Heart Failure Model Caused by Inflammatory Cytokines and Establishment of Prophylactic and Therapeutic Strategies for the Heart Failure

1997 - 1997 サイトカインによる血管リモデリングの分子機構におけるチロシンキナーゼの役割

1996 - 1997 Analysis of the effects of Gla-containing proteins and their receptors on the proliferation of vascular smooth muscle cells.

1995 - 1997 molecular mechanisms of vascular thrombosis

1995 - 1997 Physiological and pathophysiological roles of endothelium-derived hyperpotarizing factor in the control of organ perfusion.

1995 - 1996 The role of inflammatory mechanisms in the pathogenesis of ischemic heart disease. Basic and clinical studies.

1994 - 1996 ROLE OF MICROVASCULAR DISORDERS IN THE PATHOGENESIS OF MYOCARDIAL ISCHEMIA

1993 - 1994 Role of Inflammatory Cytokines in the Development and Progression of Ischemic Heart Diseases-Experimental and Clinical Studies-

1993 - 1993 心臓発生過程および成熟心臓機能における線維芽細胞成長因子の役割の解明

1993 - 1993 心不全における内皮依存性血管拡張能異常に関する研究

1992 - 1993 A development and A basic research of New Thermal Balloon Catheter for Percutaneous Transvenous Coronary Angioplasty

1992 - 1992 エイコサペンタエン酸のサイトカイン動態に及ぼす影響に関する臨床的及び実験的研究

1992 - 1992 孤束核ニューロンのシナプス伝達における酸化窒素の役割に関する研究:特に逆行性精報伝達物質としての可能性について

1992 - 1992 心不全における内皮依存性血勘拡張能異常に関する研究

Study on Ischemic Heart Disease

虚血性心疾患に関する研究

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Papers (1,145)：

Tomohiro Ito, Takashi Noda, Kotaro Nochioka, Takashi Shiroto, Nobuhiko Yamamoto, Hiroyuki Sato, Takahiko Chiba, Yuhi Hasebe, Makoto Nakano, Hiroyuki Takahama, et al. Clinical impact of atrial fibrillation progression in patients with heart failure with preserved ejection fraction: A report from the CHART-2 Study. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2024
Hiroshi Takiguchi, Mizuki Miura, Shin-Ichi Shirai, Yoshimitsu Soga, Michiya Hanyu, Genichi Sakaguchi, Yoshiharu Soga, Yoshio Arai, Shin Watanabe, Takeshi Kimura, et al. Mitral regurgitation is associated with similar loss of von Willebrand factor large multimers but lower frequency of anemia compared with aortic stenosis. Research and practice in thrombosis and haemostasis. 2024. 8. 4. 102431-102431
Shinsuke Yamanaka, Kotaro Nochioka, Hideka Hayashi, Takashi Shiroto, Jun Takahashi, Satoshi Miyata, Satoshi Yasuda, Hiroaki Shimokawa. Age-stratified profiles and outcomes of patients with heart failure with preserved ejection fraction. ESC heart failure. 2024
高濱博幸, 後岡広太郎, 宮田敏, 林秀華, 井上巧, 薄田海, 大山宗馬, 白戸崇, 高橋潤, 下川宏明, et al. Association of Body Mass Index with Ten-Year Outcomes in Pre-Clinical Asymptomatic Stage A/B Heart Failure: Insights from the CHART-2 Study(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ011-1
井上巧, 後岡広太郎, 宮田敏, 白戸崇, 林秀華, 大山宗馬, 薄田海, 高濱博幸, 高橋潤, 下川宏明, et al. Rehospitalization Frequency and Prognostic Implications in Chronic Heart Failure: Insights from the CHART-2 Study(タイトル和訳中). 日本循環器学会学術集会抄録集. 2024. 88回. PJ099-3

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MISC (1,437)：

大内大輝, 森翔平, 荒川元孝, 荒川元孝, 進藤智彦, 下川宏明, 安田聡, 金井浩, 金井浩. Investigation of irradiation conditions for low intensity pulsed ultrasound to induce angiogenesis. 超音波医学 Supplement. 2023. 50
鈴木秀明, 松本泰治, 大田英揮, 杉村宏一郎, 後岡広太郎, 高橋潤, 宮田敏, 古川勝敏, 福本義弘, 瀧靖之, et al. 高齢者における循環器疾患に対する応用薬理慢性心不全患者における脳由来成長因子(BDNF)と脳灰白質量との関連慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2). 応用薬理. 2022. 102. 5-6. 123-123
後岡広太郎, 安田聡, 植田琢也, 白戸崇, 高橋潤, 宮田敏, 宮田敏, 下川宏明, 下川宏明. AIによる心不全のフェノマッピング:CHART-2研究より. 日本心不全学会学術集会プログラム・抄録集. 2022. 26th
宮坂智充, 川上佳織, 中村豊, 宮田敏, 佐藤美希, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, et al. 喘息・食物アレルギー気管支リンパ節でのTh2細胞の分化に関与するヒトμオピオイド受容体遺伝子一塩基多型. アレルギー. 2021. 70. 6-7. 802-802
宮坂智充, 川上佳織, 中村豊, 宮田敏, 目時弘仁, 曽良一郎, 山内広平, 河野資, 下川宏明, 高柳元明, et al. 気管支喘息におけるTh2型免疫応答の亢進に関与するμオピオイド受容体遺伝子一塩基多型. 日本呼吸器学会誌. 2021. 10. 増刊. 169-169

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Patents (1)：

衝撃波アブレーションシステム

Books (90)：

New Trends in Shock Wave Applications to Medicine and Biotechnology, pp.
XX-XX, Research Signpost, India, 2010
循環器の基本薬を使いこなす.
文光堂 2010
テーラーメード治療のための治療薬の選択と使用法ガイドライン
文光堂 2010
血管疾患を診る・治す.
文光堂 2010
Annual Review循環器2009
中外医学社 2009

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Lectures and oral presentations (556)：

<会長講演>目に見えないものの大切さ
(第62回日本心臓病学会学術集会 2014)
<A Year in Cardiology --The EHJ Perspective/The 62nd Annual Japanese College Scientific Session of Cardiology>Conclusion.
(第62回日本心臓病学会学術集会 2014)
Importance of coronary vasomotion abnormalities.
(第62回日本心臓病学会学術集会 2014)
Chronic Heart Failure Analysis and Registry in the Tohoku District of Japan --The CHART Studies-
(18th Annual Scientific Assembly of Heart Failure Society of America 2014)
<William Harvey Lecture>Importance of coronary vasomotion abnormalities --From bench to bedside-
(European Society Congress 2014 2014)

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Education (1)：

- 1979 Kyushu University Faculty of Medicine 医学部医学科

Professional career (1)：

医学博士 (Kyushu University)

Work history (22)：

2023/08 - 現在 Tohoku University Graduate School of Medicine Visiting Professor, Emeritus Professor, Graduate School of Medciine
2020/04 - 現在 International University of Health and Welfare Graduate School Vice President
2007/04 - 2022/09 東北大学大学院循環器EBM開発学寄附講座 Professor and Chairman
2006/04 - 2022/09 東北大学大学院循環器先端医療開発学寄附講座 Professor and Chairman
2014/07 - 2020/04 東北大学病院循環器センターセンター長

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Committee career (36)：

2009/04 - 現在日本性差医学・医療学会理事
2009/04 - 現在日本酸化ストレス学会理事
2009/04 - 現在日本循環器心身医学会理事
2009/04 - 現在日本性差医学・医療学会理事
2009/04 - 現在日本酸化ストレス学会理事

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Awards (13)：

2019/10 - 日本酸化ストレス学会日本酸化ストレス学会学会賞
2019/04 - 文部科学省文部科学大臣表彰「科学技術賞・研究部門」
2014/08/31 - ヨーロッパ心臓病学会(ESC) William Harvey Lecture Award, 2014 European Society of Cardiology (ESC)
2014/04 - 文部科学省 The Commendation for Science and Technology, the Minister of Education,Culture, Sports, Science and Technology, Prizes for Science and Technology
2012/11/01 - 日本医師会日本医師会医学賞

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Association Membership(s) (20)：

日本循環器心身医学会(2009/04- 理事) , 日本酸化ストレス学会(2009/04- 理事) , 日本性差医学・医療学会(2009/04- 理事) , 日本循環器学会(1979/04- 理事) , European Society of Cardiology (ESC)(2003/01- 評議員) , American Heart Association (AHA)(2000/07- 評議員) , American Physiological Society (APS)(1989/07- 評議員) , 日本血管細胞生物学会(2006/01- 評議員) , 日本炎症学会(1990/09-) , 日本脈管学会(1989/07- 評議員) , 日本心不全学会(1997/07- 理事) , 日本高血圧学会(2003/04- 評議員) , 日本フリーラジカル学会(2003/08- 評議員) , 日本適応医学会(1999/07- 評議員) , 日本心脈管作動物質学会(2001/06- 理事) , 日本NO学会(2002/05- 理事) , 日本心臓病学会(1990/09- 理事) , 日本内科学会(1989/08- 評議員) , 日本動脈硬化学会(2001/06- 評議員) , 日本循環器学会(2002/04-2004/03 学術集会運営委員会幹事)

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