Imai Hiroshi

イマイヒロシ | Imai Hiroshi

Affiliation and department：
Job title： Assistant Professor
Homepage URL (2)： http://www.bio.sci.osaka-u.ac.jp/bio_web/lab_page/kon/ , http://www.bio.sci.osaka-u.ac.jp/bio_web/lab_page/kon/index-e.html

Research field (3)： Cell biology , Biophysics , Structural biochemistry

Research keywords (3)： cry-electron microscopy , microtubule , dynein

Research theme for competitive and other funds (6)：

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Papers (8)：

Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, et al. A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light. Science Advances: Vol. 7, no. 9, eabf3621 DOI: 10.1126/sciadv.abf3621. 2021. 7. 9
Rie Ayukawa (*), Seigo Iwata (*), Hiroshi Imai (*), Shinji Kamimura, Masahito Hayashi, Kien Xuan Ngo, Itsushi Minoura, Seiichi Uchimura, Tsukasa Makino, Mikako Shirouzu, et al. GTP-dependent formation of straight oligomers leads to nucleation of microtubules. J Cell Biol 220 (4): e202007033. 2021. 220. 4
T. Sato, T. Shirane, Y. Wada, H. Imai, S. Kamimura. Development of phase contrast/dark-field microscopy with scanning laser illumination. J. Inst. Sci. Eng. Chuo Univ. 2019. 49
Hiroshi Imai, Tomohiro Shima, Kazuo Sutoh, Matthew L. Walker, Peter J. Knight, Takahide Kon, Stan A. Burgess. Direct observation shows superposition and large scale flexibility within cytoplasmic dynein motors moving along microtubules. NATURE COMMUNICATIONS. 2015. 6. 8179
Hiroshi Imai, Akihiro Narita, Yuichiro Maeda, Trina A. Schroer. Dynactin 3D Structure: Implications for Assembly and Dynein Binding. JOURNAL OF MOLECULAR BIOLOGY. 2014. 426. 19. 3262-3271

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MISC (2)：

Etsuko Muto, Rie Ayukawa, Seigo Iwata, Hiroshi Imai, Shinji Kamimura, Ken Sekimoto, Gigant Benoit. GTP-Dependent Formation of Straight Oligomers Leads to Nucleation of Microtubules. BIOPHYSICAL JOURNAL. 2021. 120. 3. 12A-12A
今井洋, 昆隆英. 動物細胞に共通する細胞内の輸送システム. 生産と技術. 2018. 70. 4. 73-76

Books (1)：

Handbook of dynein (Second edition)
Jenny Stanford Publishing 2019 ISBN:9789814800013

Lectures and oral presentations (19)：

Development of a new method to measure dissociation constant of filamentous protein complexes by electron microscopy
(The 59th Annual Meeting of the Biophysical Society of Japan 2021)
Novel isolated ciliary dynein structure revealed by negative stain EM
(The 59th Annual Meeting of the Biophysical Society of Japan 2021)
Effects of high hydrostatic pressure on intracellular Ca2+ concentration of sea urchin swimming live sperm
(2020)
How do GTP-tubulins nucleate microtubules? (2)Lateral association of oligomers.
(2020)
Release mechanism of the shutdown state of cytoplasmic dynein revealed by electron microscopy
(2020)

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Education (1)：

Professional career (1)：

Work history (5)：

2017/04 - 現在大阪大学大学院理学研究科生物科学専攻助教
2015/04 - 2017/03 Chuo University Faculty of Science and Engineering
2009/04 - 2015/03 英国リーズ大学 Astbury Centre for Structural Molecular Biology. Research Fellow
2005/04 - 2009/03 Japan Science and Technology Agency
2003/04 - 2005/03 RIKEN

Awards (1)：

2016/03 - 15th Alpbach Motors Workshop, Myosin and Muscle, and other Motors. Alpbach Motor Meeting Award

Association Membership(s) (2)：

Zoological Society of Japan , THE BIOPHYSICAL SOCIETY OF JAPAN

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