Takamune Nobutoki

タカムネノブトキ | Takamune Nobutoki

Affiliation and department：

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (22)：

2023 - 2026 Mass spectrometric analysis of native protein-RNA complex from HIV-1-infected cells for HIV control
2022 - 2025 Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoating
2022 - 2025 Development of novel HIV-1 capsid (CA) inhibitors, and determination regarding novel mechanism of CA uncoating
2019 - 2022 Development of basic technology for creating mucosal vaccines using unique medium-chain fatty acids secreted by worker bees
2018 - 2021 Fundamental study of NER mechanism aiming to develop a novel HIV therapy in next generation

2015 - 2018 Investigation of novel expression mechanism of HIV pathogenic protein to develop the next generation HIV therapy

2015 - 2018 Prevention of a virus propagation based on cellular factors controlling HIV infection

2015 - 2017 Development and application of M-cell targeting new adjuvant for mucosal immunization

2012 - 2015 Study to develop novel anti-HIV strategy targeting to weak point of HIV life cycle

2012 - 2015 Exploration of cellular host factor required for HIV-1 infection and approaches to overcome multi-drug resistant HIV-1

2010 - 2011 New strategy for inhibition of HIV replication by targeting to NMT1 without appearance of drug resistant virus

2009 - 2011 Development of the next generation of AIDS vaccine candidates based on the immune response of HIV-resistant individuals.

2008 - 2009 Strategy for inhibition of HIV-1 replication without appearance of drug resistant virus and attenuation of the virus

2004 - 2006 Development of HIV-1 coreceptor-based HIV /AIDS defense vaccine

2004 - 2005 HIV-1コレセプターの特殊立体構造に対する分子認識自己抗体誘導によるエイズ制御

2004 - 2004 ヒト型HIV感染防御抗体・ヒト型エイズ発症防止抗体の創製のための生化学的基礎研究

2003 - 2003 HIV-1コレセプターの特殊立体構造に対する分子認識自己抗体誘導によるエイズ制御

2002 - 2003 HIV-1感染細胞が誘導する神経細胞死のプロテオーム解析

2002 - 2002 HIV-1コレセプターの特殊構造に対する立体特異的自己抗体誘導によるエイズ制御

2001 - 2001 耐性ウイルスに有効な抗HIV薬及びコレセプターを基礎にした感染防御法の開発

2000 - 2000 耐性ウイルスに有効な抗HIV薬及びコレセプターを基礎にしたワクチンの開発

1999 - 2000 DISCOVERY OF SUICIDE PEPTIDE-INHIBITOR OF HIV-1 PROTEASE

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Papers (65)：

Haydar Bulut, Nobuyo Higashi-Kuwata, Hiromi Ogata-Aoki, Hironori Hayashi, Nobutoki Takamune, Naoki Kishimoto, Debananda Das, Mi Li, Alexander Wlodawer, Shogo Misumi, et al. Impact of Single Halogen Atom Substitutions on Antiviral Profile of Inhibitors Targeting SARS-CoV-2 Main Protease. ACS Omega. 2026
Daichi Kusakari, Naoki Kishimoto, Kazuyuki Oshiro, Yui Udeda, Nobutoki Takamune, Keiichi Motoyama, Shogo Misumi. Targeting envelope lipids with 2,6-di- O -methyl-3-acetyl-β-cyclodextrin impairs infectivity of SARS-CoV-2 and Japanese encephalitis virus. Journal of Virology. 2025. 99. 12
Tomofumi Nakamura, Nobutoki Takamune, Mayu Okumura, Jun-ichirou Yasunaga, Masaharu Sugiura, Masayuki Amano. Covalent anti-HIV compound that induces HIV-1 capsid multimerization and degradation decomposes the viral core. 2025
Nobuyo Higashi-Kuwata, Haydar Bulut, Hironori Hayashi, Kohei Tsuji, Hiromi Ogata-Aoki, Maki Kiso, Nobutoki Takamune, Naoki Kishimoto, Shin-Ichiro Hattori, Takahiro Ishii, et al. An orally available P1'-5-fluorinated Mpro inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. PNAS nexus. 2025. 4. 1. pgae578
中村朋文, 高宗暢暁, 奥村真由, 中田浩智, 安永純一朗, 天野将之. 共有結合性HIV-1カプシド阻害剤の開発と作用機序の解明. 日本エイズ学会誌. 2024. 26. 4. 445-445

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Professional career (1)：

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