Rchr
J-GLOBAL ID：200901018232803791   Update date: Aug. 17, 2024

Masai Hisao

マサイ ヒサオ | Masai Hisao
Affiliation and department：
Tokyo Metropolitan Institute of Medical Science Department of Basic Medical Sciences

About Tokyo Metropolitan Institute of Medical Science Department of Basic Medical Sciences


Job title： Director
Homepage URL  (1)： http://www.igakuken.or.jp/genome/
Research field  (3)： Functional biochemistry ,  Molecular biology ,  Molecular biology
Research keywords  (20)： DNA Replication ,  Replication timing ,  Replication stress ,  複製フォーク停止 ,  Genome stability ,  cell cycle ,  Chromosome higher-order structure ,  Cdc7 kinase ,  Rif1 protein ,  PriA protein ,  Mrc1/Claspin protein ,  MCM helicase complex ,  RNA-DNA hybrid ,  R-loop ,  G-quadruplex ,  E.coli ,  分裂酵母 ,  ES細胞 ,  制癌剤 ,  キナーゼ(リン酸化酵素)
Research theme for competitive and other funds  (54)：
  • 2020 - 2025 On-grid biochemistry: Structural analyses of G-quadruplex-telomere factor complexes
  • 2022 - 2024 Roles of G-quadruplexes in initiation of DNA replication and their biological significance
  • 2020 - 2024 Positive and negative regulation of DNA replication by G-quadruplex/ RNA-DNA hybrids
  • 2021 - 2023 Regulation of nuclear periphery chromatin architecture by Rif1 through its binding to G-quadruplex
  • 2020 - 2023 Carcinogenesis induced by biological stresses
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Papers (181)：
  • Kosuke Yamazaki, Tomohiro Iguchi, Yutaka Kanoh, Kazuto Takayasu, Trinh Thi To Ngo, Ayaka Onuki, Hideya Kawaji, Shunji Oshima, Tomomasa Kanda, Hisao Masai, et al. Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage. Cell Cycle. 2024. 1-16
  • Kosuke Yamazaki, Tomohiro Iguchi, Yutaka Kanoh, Kazuto Takayasu, Trinh Thi To Ngo, Ayaka Onuki, Hideya Kawaji, Shunji Oshima, Tomomasa Kanda, Hisao Masai, et al. Homologous recombination contributes to the repair of acetaldehyde-induced DNA damage. Cell cycle (Georgetown, Tex.). 2024. 1-16
  • Youichi Tajima, Futoshi Shibasaki, Hisao Masai. Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance. Cancer gene therapy. 2024. 31. 1. 158-173
  • Karin Hori, Satoshi Yamazaki, Chiaki Ohtaka-Maruyama, Tomio Ono, Tomohiro Iguchi, Hisao Masai. Cdc7 kinase is required for postnatal brain development. Genes to cells : devoted to molecular & cellular mechanisms. 2023. 28. 10. 679-693
  • Wendi Sun, Kian Leong Lee, Lorenz Poellinger, Hisao Masai, Hiroyuki Kato. Catalytic domain-dependent and -independent transcriptional activities of the tumour suppressor histone H3K27 demethylase UTX/KDM6A in specific cancer types. Epigenetics. 2023. 18. 1
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MISC (107)：
  • IGUCHI Tomohiro, YAMAZAKI Satoshi, ONO Tomio, ISHII Rie, HORI Karin, KOBAYASHI Shunsuke, SASANUMA Hiroyuki, MASAI Hisao. Neural stem cell- or Hematopoietic stem cell-specific knockout of Cdc7 or ASK(Dbf4) exhibits common and distinct phenotypes. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 杉山僚, 大塚海, 服部竜也, 多田羅麻由, 荒木啓伍, 飯塚瑞穂, 中田一歩, 井口智弘, 正井久雄, 行川賢, et al. Dynamic nuclear lamina-chromatin interactions during spermatogenesis. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 多田羅麻由, 船越万結花, 杉山僚, 荒木啓伍, 中田一歩, 井口智弘, 正井久雄, 小林久人, 行川賢, 前澤創. Spatiotemporal dynamics of chromatin accessibility at the transition of mitosis-to-meiosis. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
  • 正井久雄, 井口智弘, 伊藤さゆり, 加納豊, 覺正直子, 深津理乃, 森山賢治, 笹沼博之. 核酸-タンパク質-リン脂質相互作用を介した染色体高次構造の形成制御. 日本生化学会大会(Web). 2022. 95th
  • IGUCHI Tomohiro, YAMAZAKI Satoshi, ONO Tomio, ISHII Rie, HORI Karin, KOBAYASHI Shunsuke, MASAI Hisao. The activation subunit of Cdc7, ASK(Dbf4), but not Cdc7 catalytic subunit, is essential for immune cell proliferation and differentiation. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
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Patents (7)：
  • 細胞周期可視化プローブ
  • Cdc7-ASKキナーゼ複合体、該キナ-ゼ複合体の基質、及び該基質に特異的な抗体、並びにこれらを用いたCdc7-ASKキナーゼ阻害能を有する化合物のスクリーニング方法
  • Human H37 protein and cDNA encoding the protein
  • ヒトH37タンパク質とこのタンパク質をコードするcDNA
  • Cdc7-ASK kinase complex, a substrate thereof, an antibody specific to the phosphorylated substrate and a method using these to screen for substances capable of inhibiting Cdc7-ASK kinase activity.
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Books (23)：
  • Science Forum 科学フォーラム:遺伝情報の複製と利用の最前線
    東京理科大学 2022
  • セントラルドグマの新常識 : 転写・翻訳の驚きの新機構と再定義されるDNA・RNA・タンパク質の世界
    羊土社 2022 ISBN:9784758104043
  • 岡崎フラグメント発見50周年 DNA複製研究の歴史と最前線
    現代化学 2019
  • 微生物のゲノム複製のストラテジー: -レプリコン仮説再考
    生物と科学 遺伝 2018
  • “DNA Replication, From Old Principles to New Discoveries” (Masai, H. and Foiani, M. Eds) Adv Exp Med Biol.
    Springer 2018 ISBN:9789811069550
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Lectures and oral presentations  (15)：
  • Replication timing regulation by Rif1 protein through interaction with nuclear membrane
    (20th Ataxia-Telangiectasia Workshop (ATW-2024)/ 15th international symposium on DNA Damage Response & Human Disease (isDDRHD-2024) 2024)
  • Novel roles of Claspin in cellular responses to environmental stresses
    (CSH-Asia Conference: DNA Metabolism, Genomic Stability and Human Disease 2024)
  • Regulation of replication timing and DNA repair by nuclear membrane tethering of Rif1
    (The 14th International Symposium on DNA Damage Response & Human Disease 2023)
  • Biological functions of G-quadruplexes in regulation of DNA replication
    (50th International Symposium on Nucleic Acid Chemistry 2023)
  • Roles of unusual DNA structures in regulation of DNA replication
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Education (4)：
  • - 1987 University of Tokyo, graduate school Graduate School, Division of Science Biochemistry
  • - 1981 University of Tokyo Faculty of Science Department of Biophysics and Biochenistry
  • The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
  • The University of Tokyo
Professional career (1)：
  • Ph.D.
Work history (32)：
  • 2018/04 - 現在 Tokyo Metropolitan Institute of Medical Science Director General
  • 2006/04 - 現在 東京都医学総合研究所 参事研究員
  • 2005 - 現在 :東京理科大学 理学部 客員教授
  • 2004 - 現在 :東京大学 大学院(新領域創成科学研究科) 客員教授
  • 2016/04 - 2023/03 北里大学 理学部 生物科学科 分子生物学講座
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Committee career (10)：
  • 2017/04 - 現在 山田科学振興財団 選考委員
  • 2013/06 - 現在 Biochemical and Biophysical Research Communications Editor
  • 2011/06 - 現在 Faculty Opinion (Faculty1000) member
  • 2010 - 現在 日本学術会議 連携会員
  • 2009/04 - 現在 Genes to Cells Associate Editor
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Awards (3)：
  • 2017/04 - 文部科学省 平成29年度文部科学大臣表彰 科学技術賞(研究部門) 「ゲノムDNA複製を制御するメカニズムの研究」
  • 2012/10 - A-IMBN (Asian International Molecular Biology Network) Arthur Kornberg Memorial Lecture Award
  • 2006/11 - 東京都 東京都職員表彰(研究、発明・発見分野) 「生殖細胞形成時の遺伝子組換えに必要な分子の発見」
Association Membership(s) (5)：
日本癌学会 ,  日本生化学会 ,  日本分子生物学会 ,  Japanese Biochemistry Society ,  Japanese Molecular Biology Society
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