Okamoto Takayuki

オカモトタカユキ | Okamoto Takayuki

Affiliation and department：
Homepage URL (1)： http://www.med.shimane-u.ac.jp/pharmacology/index.html

Research field (3)： Medical biochemistry , Pharmacology , Pathobiochemistry

Research keywords (5)：炎症 , メカノバイオロジー , 血管内皮 , 血栓止血 , Drug Delivery System

Research theme for competitive and other funds (28)：

2024 - 2027 敗血症における動脈スティフネスの分子基盤と制御
2024 - 2027 COVID-19血管病変のメカノトランスダクション制御
2020 - 2023 YAP阻害による敗血症性臓器障害の制御
2020 - 2023 非アルコール性脂肪性肝疾患において発現が増加するmiRNAの機能解析
2019 - 2022 Molecular mechanism of cooperation between endothelial cell stiffness and functions.

2019 - 2022 Development of a prediction system of systemic disease using AI technology based on oral flora.

2018 - 2021 Establishment of evaluation method for arteriosclerotic lesions by measuring the "hardness" of blood vessels using an atomic force microscope

2016 - 2019 The role of gap junction-mediated regulation of endothelial cellular stiffness

2016 - 2019 The peritoneum omentum exosomes in the septic immune paralysis

2016 - 2018 Interaction between beta2 integrin and thrombomodulin effect to immunothrombosis

2016 - 2018 Establishment of diagnostic method for leaky gut syndrome using mice model.

2016 - 2018 The ability of human extracellular vesicles to augment inflammatory host response in septic shock

2014 - 2016 Analysis of the interaction between neutrophil and thrombomodulin.

2013 - 2016 Endothelial cellular gap junctions regulate the vascular angiogenesis

2013 - 2016 Molecular pathological studies on the effect of anticoagulant protein C pathway on the regulation of tumorgenesis

2012 - 2015 Aberrant activation of interns in the pathogenesis of immune diseases

2010 - 2011 Regulation of endothelial cell functions by anticoagulant factors and gap junction.

2009 - 2011 Studies on Molecular-Cellular Mechanisms of Protein C Anticoagulant Pathway Crucial for Life Homeostasis

2007 - 2008 Functional analysis of gap junction protein connexin32 in endothelial cells

2007 - 2008 Studies on Molecular-Cellular Mechanisms of Protein C AnticoagulantPathway Crucial for Life Maintenance

2006 - 2007 Mechanism of inhibitory effect of protein C inhibitor on tumorigenesis and angiogenesis

2005 - 2006 血管障害性疾患に対する新規なリスク分子・標的治療分子の探索研究

2005 - 2006 Molecular pathobiological studies on anti-coagulant protein C pathway which is essential for the vital functions

2004 - 2005 Effect of protein C inhibitor on renal cell carcinogenesis and on tumor invasion, growth and metastasis

2004 - Search of a new anti-thrombosis molecule

血管内皮細胞における細胞間相互作用の解析

血管内皮細胞のメカノバイオロジーの解明

炎症と血液凝固のクロストークの解明

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Papers (105)：

岡本貴行, 勝部由貴子, 服部舞, 臼田春樹, 太田淳一, 二階哲朗, 和田孝一郎. トロンボモジュリンは血管内皮細胞のホルネリンと相互作用して血管新生を調節する. 日本血栓止血学会誌. 2024. 35. 2. 359-359
二階哲朗, 岡本貴行, 松本慶太, 勝部由貴子, 服部舞. HistoneがLPS敗血症モデルへ与える影響についての検討. Shock: 日本Shock学会雑誌. 2023. 37. 1. 91-91
Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Koichi Nakamura, Tomohito Hagi, Tomoki Nakamura, Motomu Shimaoka, Akihiro Sudo. A Novel Approach to Reducing Lung Metastasis in Osteosarcoma: Increasing Cell Stiffness with Carbenoxolone. Current issues in molecular biology. 2023. 45. 5. 4375-4388
Usuda Haruki, Niibayashi Tomomi, Morita Yusuke, Endo Akihiro, Okamoto Takayuki, Tanabe Kazuaki, Wada Koichiro. Patients with cardiovascular diseases exhibit distinct characteristics in their oral microbiome and are more susceptible to infections by pathogenic bacteria. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 3-B-P-046
Okamoto Takayuki, Katsube Yukiko, Hattori Mai, Usuda Haruki, Ota Junichi, Nikai Tetsuro, Wada Koichiro. Hornerin expressed in endothelial cells implicates in angiogenesis. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2023. 97. 3-B-O19-2

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MISC (52)：

岡本貴行, 臼田春樹, 和田孝一郎. 血管内皮細胞の硬さとギャップ結合におけるYAPの役割. 日本薬理学雑誌. 2023. 158. Supplement
臼田春樹, 新林友美, 岡本貴行, 和田孝一郎. 好酸球性食道炎患者における高病原性口腔内細菌の保菌および口腔内細菌叢についての基礎的検討. 日本薬理学雑誌. 2022. 157. Supplement
JAHAN Israt, OKAMOTO Takayuki, USUDA Haruki, TANAKA Tetsuya, NIIBAYASHI Tomomi, NAKAJIMA Atsushi, WADA Koichiro. MiR-126-3p and MiR-199a-3p Promote Lipid Accumulation in 3T3-L1 Adipocytes via Regulating HIF-1α and C/EBPα Expression. Shimane Journal of Medical Science (Web). 2022. 39. 4
USUDA Haruki, KANDA Syoma, OKAMOTO Takayuki, WADA Koichiro. Lacking dietary fiber enhances sensitivity to inflammatory stimuli, that results in intestinal hyper-permeability. 日本薬理学会年会(Web). 2021. 94th
Takayuki Okamoto, Eiji Kawamoto, Haruki Usuda, Tetsuya Tanaka, Tetsuro Nikai, Kunihiro Asanuma, Koji Suzuki, Motomu Shimaoka, Koichiro Wada. RECOMBINANT HUMAN SOLUBLE THROMBOMODULIN REDUCES LIPOPOLYSACCHARIDE-INDUCED ENDOTHELIAL CELL STIFFENING AND MONOCYTE. SHOCK. 2020. 53. 18-19

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Professional career (1)：

master (Osaka University)

Work history (1)：

2004/08 - ~三重大学大学院医学系研究科助教2013年12月~三重大学大学院医学系研究科研究科内講師

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