2015 - 2018 Development of anti-hepatitis virus strategy based on proteomics
2014 - 2017 Search for antiviral molecules from coral reef organisms
2013 - 2016 海洋生物を創薬ソースとしたC型慢性肝炎治療薬候補化合物の探索
2012 - 2014 Infection of hepatitis C virus-related non-primate hepacivirus in Japan and analysis on its replication mechanism
2010 - 2013 The role of microtubules structure in hepatitis C virus replicationand the possibility of its target molecule for anti-HCV agent
2010 - 2013 ウイルス性肝炎の病態に応じたウイルス側因子の解明と治療の応用
2009 - 2010 ミツバチ産物によるC型肝炎ウイルス増殖抑制効果の検討
2007 - 2008 C型肝炎ウイルス治療薬評価に有用な迅速評価系(レプリコン細胞)の構築
2004 - 2007 HIV感染者のエイズ発症抑制に関する遺伝的・免疫学的素因の解析
2004 - 2007 細胞免疫誘導型prime/boostエイズワクチンの臨床評価系の確立
2002 - 2004 Biological and Socio-Medical Studies to Establish Anti-AIDS/HIV Strategies in Sub-Saharan Countries, Especially Zambia
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Papers (58):
Atsuya Yamashita, Hirotake Kasai, Shinya Maekawa, Tomohisa Tanaka, Yasunori Akaike, Akihide Ryo, Nobuyuki Enomoto, Kohji Moriishi. Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replication. Antiviral research. 2024. 232. 106027-106027
Hirotake Kasai, Atsuya Yamashita, Yasunori Akaike, Tomohisa Tanaka, Yoshiharu Matsuura, Kohji Moriishi. HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1. mBio. 2024. e0169124
Masaaki Toyama, Koichi Watashi, Masanori Ikeda, Atsuya Yamashita, Mika Okamoto, Kohji Moriishi, Masamichi Muramatsu, Takaji Wakita, Ashoke Sharon, Masanori Baba. Novel Neplanocin A Derivatives as Selective Inhibitors of Hepatitis B Virus with a Unique Mechanism of Action. Antimicrobial Agents and Chemotherapy. 2022
Tomohisa Tanaka, Kaori Okuyama-Dobashi, Ryoji Motohashi, Hiromasa Yokoe, Kazunori Takahashi, Pattama Wiriyasermkul, Hirotake Kasai, Atsuya Yamashita, Shinya Maekawa, Nobuyuki Enomoto, et al. Inhibitory effect of a novel thiazolidinedione derivative on hepatitis B virus entry. Antiviral Research. 2021. 194. 105165-105165
Teruhime Otoguro, Tomohisa Tanaka, Hirotake Kasai, Nobuhiro Kobayashi, Atsuya Yamashita, Takasuke Fukuhara, Akihide Ryo, Moto Fukai, Akinobu Taketomi, Yoshiharu Matsuura, et al. Establishment of a Cell Culture Model Permissive for Infection by Hepatitis B and C Viruses. Hepatology Communications. 2021. 5. 4. 634-649
2002/10 - 2007/03 University of Yamanashi Faculty of Medicine
2001/04 - 2002/09 山梨医科大学 医学部 微生物学講座 助手
1997/04 - 2001/03 医薬品副作用被害救済研究振興調査機構 派遣研究員
1995/04 - 1997/03 財団法人エイズ予防財団 リサーチレジデント
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Association Membership(s) (5):
The Japanese Society for Virology
, The Japanese Society for AIDS Research
, Japanese Society for Immunology
, The Japanese Association for Antiviral Therapy
, The Molecular Biology Society of Japan