Rchr
J-GLOBAL ID：200901018343325937
Update date: Nov. 06, 2024
Ueda Tadashi
ウエダ タダシ | Ueda Tadashi
Affiliation and department：
Research field (4)：
Pharmaceuticals - analytical and physicochemistry
, Biophysics
, Pharmacology
, Structural biochemistry
Research keywords (7)：
タンパク質の抗原性の調整
, タンパク質の凝集、アミロイド線維化
, P2X4 receptor
, タンパク質の安定性
, 抗体の高機能化
, タンパク質の構造と機能
, タンパク質工学
Research theme for competitive and other funds (31)：
- 2018 - 2020 免疫寛容によるAnti-Drug Antibodies産生を抑制する基盤的研究
- 2014 - 2018 神経障害性疼痛モデル動物を用いた「痛みの客観的評価」の研究基盤の確立
- 2014 - 2017 Analysis of molecular association and dissociation mechanism in replication restart
- 2015 - 2017 Fundamental Study on Preparations for Therapeutic Antibodies with Less Productions of Anti-Drug Antibodies
- 2013 - 2016 Early diagnosis of the defect in amino acid metabolism using chiral amino acid metabolomics
- 2011 - 2013 Development of Fab molecule with the stable scaffold for next generation
- 2011 - 2013 Study on the development of molecules for depressing neuropathic pain based on tertiary structure of human P2X4 receptor
- 2010 - 2012 Molecular analyses on the replication initiation complex and its novel regulatory factors in E. coli
- 2010 - 2012 Development of an enantioselective amino acid metabolome analysismethod and its clinical applications
- 2008 - 2010 Improved function of ketoamine oxidase for clinical examination reagent of diabetes by use of multiple approaches
- 2007 - 2008 High-order Structure-based Molecular Mechanisms in Replicational Initiation Complex Formation, DNA Unwinding, and Dissociation
- 2003 - 2007 大腸菌DNAの複製開始及び制御機構の構造生物学的アプローチ
- 2005 - 2006 アミロイド線維の凝集が関与するフォールディング病への有機化学からのアプローチ
- 2004 - 2006 Protein Dynamics in Complex Apparatus for the Initiation and Regulation of the Chromosomal Replication
- 2004 - 2004 βアミロイド立体構造のミクログリア活性化への影響とその抑制についての研究
- 2002 - 2003 Analysis on mechanism of severe allergic reaction caused by SNP in interleukin 13 using NMR
- 2001 - 2003 STUDY ON RATIONAL DEVELOPMENT OF NOVEL ANTIBIOTICS TAGRETING DnaA DOMAIN IV
- 2002 - 2002 核磁気共鳴装置を用いたβアミロイドペプチドのリン酸イオンによる凝集抑制機構の解明
- 2000 - 2001 AnaIysis of dynamic behavior of ribonuclease upon ligand binding using high resolution NMR
- 1998 - 1998 カルシウム結合部位を導入したニワトリリゾチーム変異体を用いた再生初期構造の形成要因の解明
- 1997 - 1998 Analysis of epitope specificity of immune response involved in periodontitis
- 1997 - 1997 変異体を用いたリゾチームの構造構築過程の解析
- 1996 - 1997 Construction of an effective renaturation method of denatured proteins based on a biological function
- 1996 - 1997 STRATEGY FOR DEPRESSION OF IRREVERSIBLE REACTIONS OF PEPTIDES OR PROTEINS AS MEDICINE
- 1996 - 1996 タンパク質の高次構造に依存する抗原エピトープ同定法の開発
- 1996 - 1996 ランダム変異を用いたリゾチームのフォルディング情報の解析
- 1995 - 1996 Analysis of dynamic behavior of mutant hen lysozyme with larger catalytic constant using high resolution NMR
- 1995 - 1995 ランダム変異を用いたリゾチームのフォルディング情報の解析
- 1994 - 1994 ペプチドフラグメントを用いたリゾチーム構造形成初期過程の解析
- 1993 - 1993 カルシウム結合部位を導入した変異リゾチームの巻戻し活性中間体の捕捉とその構造決定
- 1989 - 1990 Study on the Renaturation of Mutant Lysozymes Expressed in Schericia Coli.
Show all
Papers (172)：
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Kosuke Oyama, Tadashi Ueda. Relationship between protein conformational stability and its immunogenicity when administering antigens to mice using adjuvants-Analysis employed the CH2 domain in human antibodies. PLOS ONE. 2024. 19. 7. e0307320-e0307320
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Akira Tsukamoto, Lee Jae Man, Kosuke Oyama, Akitsu Masuda, Hiroaki Mon, Tadashi Ueda, Takahiro Kusakabe. Effective expression and characterization of the receptor binding domains in SARS-CoV-2 Spike proteins from original strain and variants of concern using Bombyx mori nucleopolyhedrovirus in silkworm. Protein Expression and Purification. 2024. 218. 106450-106450
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Moeka Yoshikawa, Miki Senda, Hitomi Nakamura, Naoko Oda-Ueda, Tadashi Ueda, Toshiya Senda, Takatoshi Ohkuri. Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochemical and Biophysical Research Communications. 2024. 700. 149592-149592
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Kosuke Oyama, Makoto Nakakido, Takatoshi Ohkuri, Hitomi Nakamura, Kouhei Tsumoto, Tadashi Ueda. Enhancing thermal stability in the CH2 domain to suppress aggregation through the introduction of simultaneous disulfide bonds in Pichia pastoris. Protein science : a publication of the Protein Society. 2023. 32. 12. e4831
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Shogo Inoue, Yohei Ikeda, Saki Fujiyama, Tadashi Ueda, Yoshito Abe. Oligomeric state of the N-terminal domain of DnaT for replication restart in Escherichia coli. Biochimica et biophysica acta. Proteins and proteomics. 2023. 1871. 5. 140929-140929
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MISC (38)：
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Tadashi Ueda. [Modulation of Aggregation and Immunogenicity of a Protein: Based on the Study of Hen Lysozyme]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2024. 144. 3. 299-310
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植田 正. タンパク質の化学修飾ー基礎研究と抗体医薬品開発への展開. 週刊 医学のあゆみ. 2021. 278. 6. 596-601
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阿部義人, 植田 正. 低分子による抗体軽鎖変異体の安定化とアミロイド線維形成の抑制ータンパク質安定化はアミロイド形成を抑制する. 化学と生物. 2017. 55. 5. 311-312
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Relationship between protein conformational stability and its antigenicity. Clinical Immunology & Allergology. 2012. 58. 2. 239-245
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井川達弘, 阿部義人, 東貞行, 津田誠, 井上和秀, 植田正. 抗ラットP2X4抗体の調製とエピトープ解析. 日本薬学会九州支部大会講演要旨集. 2010. 27th
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Books (9)：
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薬系免疫学 改訂第4版
南江堂 2022 ISBN:9784524404117
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薬系免疫学改訂第3版
2018
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Essentialタンパク質科学
南江堂 2016 ISBN:9784524268641
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薬学領域の機器分析学
廣川書店 2013 ISBN:9784567255431
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薬系免疫学改訂第2版
南江堂 2012
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Works (2)：
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Investigation on deterioration of bioactive antibody
2000 - 2001
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Structural analysis of domain (]G0004[) in DnaA
2001 -
Education (4)：
- 1988 - 薬学博士(九州大学)
- 1983 - 1986 Kyushu University
- 1980 - 1982 九州大学薬学研究科修士課程終了 薬学研究科 修士課程 修了
- - 1980 Kyushu University School of Pharmaceutical Sciences
Professional career (2)：
- Ph.D of Pharmaceutical Sciences (Kyushu University)
- Master of Pharmaceutical Sciences (Kyushu University)
Work history (5)：
- 2023/04 - 現在 九州大学大学院薬学研究院 特任教授
- 2003/04 - 2023/03 九州大学大学院薬学研究院教授
- 1993/04 - 2003/03 九州大学大学院薬学研究科助教授
- 1992/04 - 1993/03 九州大学大学院薬学研究科助手
- 1987/04 - 1992/03 Kyushu University School of Pharmaceutical Sciences
Committee career (3)：
- 2004 - 現在 日本生化学会 評議員
- 2018/01 - 2021/12 The Journal of Biochemistry Associate Editor
- 2015/04 - 2018/03 日本学術振興会 学術システム研究センター専門研究員(担当区分:境界医学、人間医工学)
Awards (2)：
- 2021/08 - Japanese Biochemical Society THe Journal of Biochemisty Papers Award (2021) Crystal structure of the complex of the interaction domains of Escherichia coli DnaB helicase and DnaC helicase loader: structural basis implying a distortion-accumulation mechanism for the DnaB ring opening caused by DnaC binding
- 2014/10 - The Journal of Biochemistry Papers Award (2014) Characterization of deamidation at Asn138 in L-chain of recombinant humanized Fab expressed from Pichia pastoris
Association Membership(s) (6)：
The Protein Society
, PROTEIN SCIENCE SOCIETY OF JAPAN
, 日本薬学会
, 日本生化学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, D-AMINO ACID RESEARCH SOCIETY
